Download EMBO Workshop on Cell Size Regulation

EMBO Workshop on Cell Size Regulation – Provisional Program
14’th September 2016
Arrivals and registration (14:00-21:30) Shuttle buses will be organized from Berlin
airports – details from the secretariat.
Dinner (19:00-20:30)
Opening Session – Welcome Remarks and Keynote (20:30-21:30)
 Welcoming remarks
 Ines Barroso - Genes influencing metabolism and size
Opening mixer (21:30-24:00)
15’th September 2016
Size regulation within cells (8:30-10:45)
 Wallace Marshall – Regeneration of proportional structures in the ciliate Stentor
coeruleus
 Thomas Surrey – The size of the EB cap determines instantaneous microtubule
stability
 Short talk – Simone Reber - On Spindle Length and Shape
 Short talk – Hongyuan Jiang - Geometric Asymmetry Induces Upper Limit of
Mitotic Spindle Size
 Short talk – Helena Cantwell – Nuclear size control in fission yeast
 Flash talk – Martin Anger - The Role of Nuclear to Cytoplasmic Ratio in Control of
the Spindle Length
 Flash talk- David Fange – The connection between initiation of DNA replication
and cell division makes E. coli both a sizer and an adder
 Flash talk – Miriam R. Garcia – Estimation of single-cell parameters from a
distribution of bacterial size
 Flash talk – Jie-Pan Shen – Asymmetric Cell Division Actuated by Altered
MinCDE Patterning at High Expression Level Enables Cell Size Regulation in
E. coli
Coffee break (10:45-11:15)
Cell size regulation in bacteria (11:15-13:15)
 Christine Jacobs-Wagner – Cell size and shape control in bacteria
 Ariel Amir – Simultaneous regulation of size and DNA replication in bacteria: is
cell size driver or passenger?
 Short talk - Marco Cosentino – Stochasticity and key steps of cell cycle
homeostasis
 Short talk – Carolina Gallo - Bacterial growth factors: Mycoplasma pneumoniae as
a model organism
 Flash talk – Parth Pratim Pandey – Global regulation by cell division: the origin of
balanced growth and homeostasis in cells and protocells
 Flash talk – Christopher Kempes – Cross species comparisons, single-cell growth
trajectories, and physiological tradeoffs
 Flash talk – James Patterson – The biochemistry of information at the G2/M
transition
 Flash talk – Armin Haupt – A feedback between growth and polarity in fission
yeast
Lunch (13:15-14:30)
Poster session (14:30-17:00) with refreshments
Cell size regulation in yeast (17:00-19:10)
 Edda Klipp - Determinants of yeast cell size in individual cells and for a cell
population
 Jan M. Skotheim – On the biosynthetic mechanism coupling cell growth to division
at G1/S
 Naama Barkai - Interplay between protein expression and cell size regulation in
budding yeast
 Short talk – Rafael Lucena – A conserved signaling pathway coordinately controls
cell growth and size
 Short talk – Douglas Kellogg – Modulation of cell size at completion of mitosis in
budding yeast
Dinner (19:10-20:30)
Cell size regulation in bacteria II (20:30-22:10)
 Suckjoon Jun - Deconstructing cell size control into physiological modules in
bacteria
 Petra Levin – Fat makes bacteria fatter: Flux through lipid synthesis links bacterial
size to nutrient availability
 Short talk – Leigh Harris - Relative rates of surface and volume synthesis set
bacterial cell size
 Short talk – Johan Elf – Triggering replication at a fixed volume in E. coli
Open bar and poster viewing with informal discussions (22:10-24:00)
16’th September 2016
Cell size regulation in higher eukaryotes (8:30-10:30)
 Alison Lloyd – Regulation of mammalian cell size
 Robert Sablowski - Coordination between cell size, cell cycle and organ patterning
in plants
 Short talk – Clotilde Cadart - Coordination of cell cycle progression and cell
growth in animal cells to maintain size homeostasis
 Short talk – Miriam Ginzberg - Animal cells modulate cellular growth rates and cell
cycle progression to maintain uniformity of cell size
 Flash talk – Zoltan Dul – A Bioinformatics approach to find novel cell size
regulators in Arabidopsis and Human
 Flash talk – Xili Liu – Proliferating mammalian cells modulate growth rate to
reduce size variability
 Flash talk – Sean Sun – Mechanics of Volume Regulation in Eukaryotic Cells
 Flash talk – Teemu Miettinen – Cellular allometry of mitochondrial functionality
establishes the optimal cell size
Coffee break (10:30-11:00)
Signaling for cell size regulation (11:00-13:00)
 Michael Hall – mTOR signaling in growth and metabolism
 Mike Fainzilber – Acting locally to grow globally – localized mechanisms in cell
size regulation
 Short talk – Helena Soares – How does cell polarity affect cell size?
 Short talk – Shixuan Liu - Mechanisms coordinating cell size with cell cycle in
animal cells
 Flash talk – Charalampos Rallis – Response to nutrients via TOR requires
coordination of GATA-dependent transcription with intact vesicle-mediated
transport machinery
 Flash talk – Claudia Salat – Deciphering the role of a stress-dependent MAP
kinase in the control of the cell size
 Flash talk – Catherine Qiurong Pan – Role of a scaffold RhoGAP, BPGAP1, in
controlling cell size and proliferation
 Flash talk – Raquel Sitcheran – Novel functions for NIK link regulation of cell size,
mitochondrial dynamics and invasion
Lunch (13:00-14:30)
Poster session 2 (14:30-17:00) with refreshments
Cell size regulation in yeast II (17:00-18:30)
 Sophie Martin - Spatiotemporal control of cell division in fission yeast
 Short talk – Samuel Marguerat – Impact of growth and cell size on fission yeast
gene expression in single cells
 Short talk – Giuseppe Facchetti - Nodal Cdr2 density acts as a sensor of
membrane area for cell size control in fission yeast
 Short talk - Matthew Swaffer - Cell size homeostasis and variability in the fission
yeast Schizosaccharomyces pombe
Dinner (18:30-20:30)
Round Table – Debate and Discussion Session (20:30-22:00)
Open bar and poster viewing with informal discussions (22:00-24:00)
17’th September 2016
Cell size regulation in higher eukaryotes II (8:30-10:30)
 Mikael Bjorklund – On growth and proliferation - mitochondria and animal cell size
 Kazuo Yamamoto – A mechanism of cell size regulation and its readout governed
by Largen
 Short talk - Min Wu – Cell size homeostasis in mammalian cells
 Short talk – Raghu Padinjat – Independent control of TORC1 activity and Insulin
receptor feedback by a novel lipid kinase
 Short talk – Matthew Good – Cell Size-Dependent Regulation of Zygotic Genome
Activation
Coffee break (10:30-11:00)
Size and Growth Control in the Nervous System (11:00-13:10)
 Britta Eickholt – Directing neuronal PI3K growth signaling to where it is needed
 Casper Hoogenraad – Building a polarised neuron: cytoskeleton organisation and
transport mechanisms
 Patrik Ernfors – Visceral motor neuron diversity delineates a cellular basis for
nipple- and pilo-erection muscle control
 Short talk – Angela M. Kaindl – Microcephaly and cell size
 Short talk – Marija Matejcic - Understanding coordination of tissue growth and cell
cycle dynamics in the zebrafish retinal neuroepithelium
Lunch (13:10-14:30)
Tissue and organ size regulation (14:30-16:30)
 Nicolas Tapon - Tissue growth control by the Hippo signalling pathway
 Kun-Liang Guan - Hippo pathway in cell growth, organ size, and tumorigenesis
 Short talk – Doaa Megahed - The role of Hippo signaling in the regulation of organ
and cell size
 Short talk – Jasmin Imran Alsous - Collective Growth in a Simple Multicellular
Structure
 Short talk – Miri Stolovich-Rain - Cellular hypertrophy is a major contributor to
postnatal growth of pancreas and liver in rodents but not humans
Coffee break (16:30-17:00)
Closing Session – Business Meeting and Keynote (17:00-19:00)
 Business meeting – EMBO feedback forms, discussion if and where to hold
subsequent meetings, etc.
 Andrew Fisher – Size and Scale in Photography, Philosophy and Science
Farewell Dinner (20:00)
18’th September 2016
Departures with Shuttle buses to Berlin
Optional Tour of Berlin