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Name ______________________________ Class___________________Date__________________ Skills Worksheet Directed Reading Section: Mutations and Genetic Change In the space provided, explain how the terms in each pair differ in meaning. 1. mutation, mutagen _______________________________________________________________ _______________________________________________________________ _______________________________________________________________ _______________________________________________________________ 2. point mutation, silent mutation _______________________________________________________________ _______________________________________________________________ _______________________________________________________________ _______________________________________________________________ 3. reading frame, frameshift mutation _______________________________________________________________ _______________________________________________________________ _______________________________________________________________ _______________________________________________________________ Complete each statement by underlining the correct term in the brackets. 4. If a mutation causes a sequence of nucleotides to change from ACGAGA to ACGAGGA, the mutation is called a(n) [insertion / deletion] mutation. 5. Mutations that change one or just a few nucleotides in a gene on a chromosome are called [random / point] mutations. 6. If a point mutation is such that it causes a codon to specify a different amino acid, the mutation is called a [missense / silent] mutation. 7. If a mutation causes a sequence of nucleotides to change from ACGAGA to ACGGA, the mutation is called a(n) [insertion / deletion] mutation. 8. A chromosomal mutation that leads to repetitive alleles is called a(n) [inversion / duplication]. Original content Copyright © by Holt, Rinehart and Winston. Additions and changes to the original content are the responsibility of the instructor. Holt Biology 1 Genes in Action Name ______________________________ Class___________________Date__________________ Directed Reading continued Complete each statement by writing the correct term in the space provided. 9. Mutations can only be passed on to offspring if they occur in cells called ______________________ cells. 10. Mutations that cause a cell to divide uncontrollably can lead to growth of a ______________________. 11. When chromosome pairs fail to separate properly during meiosis, the error is called ______________________. 12. The condition of having two or more sets of chromosomes is called ______________________. Original content Copyright © by Holt, Rinehart and Winston. Additions and changes to the original content are the responsibility of the instructor. Holt Biology 2 Genes in Action