* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download 4-14
Non-coding DNA wikipedia , lookup
Zinc finger nuclease wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Gene therapy wikipedia , lookup
Nutriepigenomics wikipedia , lookup
Public health genomics wikipedia , lookup
Cancer epigenetics wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Genetic code wikipedia , lookup
History of genetic engineering wikipedia , lookup
Genetic drift wikipedia , lookup
Neuronal ceroid lipofuscinosis wikipedia , lookup
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing wikipedia , lookup
Cell-free fetal DNA wikipedia , lookup
Genetic engineering wikipedia , lookup
Gene therapy of the human retina wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
Genome evolution wikipedia , lookup
Gene expression programming wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Designer baby wikipedia , lookup
BRCA mutation wikipedia , lookup
Microsatellite wikipedia , lookup
Koinophilia wikipedia , lookup
Saethre–Chotzen syndrome wikipedia , lookup
Genome (book) wikipedia , lookup
Oncogenomics wikipedia , lookup
Population genetics wikipedia , lookup
Haplogroup G-P303 wikipedia , lookup
Microevolution wikipedia , lookup
BIOL 3301 GENETICS Date: Monday, April 14, 1.00-2.30 pm Subject: Gene mutation. Reading in ‘An introduction to genetic analysis’ (Griffiths et al., 7th edition) Chapter 15: Gene mutation ________________________________________________________________________ Key concepts: How DNA changes affect phenotype (15-1, 15-2) - base substitutions: transitions, transversions silent mutations, missense (synonymous & non-synonymous), nonsense, null, leaky base additions or deletions: frameshift mutations Somatic versus germinal mutation - somatic mutation, clone (15-5) germinal mutation (15-8) Mutant types (15-9, 15-11, 15-12) - morphological, lethal, conditional (restrictive/permissive), biochemical (prototropic/auxotrophic), loss-of-function, gain-of-function Occurrence of mutations - genetic screens (15-13), mutation rate/frequency (15-16, Table 15-3) Selective systems - reversion of auxotrophs (15-19) filtration enrichment (15-20) resistance (15-22, 15-23) Mutation and cancer (15-27) ____________________________________________________________ Homework: ________________________________________________________________________ Reading for next class (4-16): Chapter 16: Mechanisms of gene mutation