The importance of genetic influences in asthma REVIEW H. Los* , G.H. Koppelman*
... It has long been established that genetic factors are very important in the pathogenesis of asthma. Familial aggregation of asthma was probably first described by Sennertus in 1650 [26]. At the beginning of this century, R. Cooke performed two large studies on the inheritance of atopy, one in 1916 a ...
... It has long been established that genetic factors are very important in the pathogenesis of asthma. Familial aggregation of asthma was probably first described by Sennertus in 1650 [26]. At the beginning of this century, R. Cooke performed two large studies on the inheritance of atopy, one in 1916 a ...
introduction to genetic epidemiology
... The heuristic interpretation is that aggregation exists when cases of disease appear in families more often than one would expect if diseased cases were spread uniformly and randomly over individuals: “it runs in the family” Actual approaches for detecting aggregation depend on the nature of the ...
... The heuristic interpretation is that aggregation exists when cases of disease appear in families more often than one would expect if diseased cases were spread uniformly and randomly over individuals: “it runs in the family” Actual approaches for detecting aggregation depend on the nature of the ...
Abstracts - Parthenon Management Group
... each making a small contribution to risk of the disorder, and it also clear from multi-locus tests that perhaps a thousand or more such risk variants exist. There is also substantially evidence that these common variants overlap with those that confer risk for bipolar disorder, and emerging evidence ...
... each making a small contribution to risk of the disorder, and it also clear from multi-locus tests that perhaps a thousand or more such risk variants exist. There is also substantially evidence that these common variants overlap with those that confer risk for bipolar disorder, and emerging evidence ...
Genetics and You - Cleft Palate Foundation
... gene, one inherited from the father and one from the mother. Due to the large number of genes involved in inheritance, and because parents pass on to their children only one copy of each gene, no two children in the same family have exactly the same genetic make up (except identical twins). Each ind ...
... gene, one inherited from the father and one from the mother. Due to the large number of genes involved in inheritance, and because parents pass on to their children only one copy of each gene, no two children in the same family have exactly the same genetic make up (except identical twins). Each ind ...
Chapter 3
... • Actual approaches for detecting aggregation depend on the nature of the phenotype, but the common factor in existing approaches is that they are taken without any specific genetic model in mind. • The basic design of familial aggregation studies typically involves sampling families • In most place ...
... • Actual approaches for detecting aggregation depend on the nature of the phenotype, but the common factor in existing approaches is that they are taken without any specific genetic model in mind. • The basic design of familial aggregation studies typically involves sampling families • In most place ...
Literature Study
... of ASD are classical autism, Asperger syndrome and pervasive developmental disorder-not otherwise specified (PDD-NOS)(Baltussen, Clijsen, Leenders 2003). Individuals with an ASD can be characterized by impairment in social relationships, atypical verbal and non-verbal communication, difficulties wit ...
... of ASD are classical autism, Asperger syndrome and pervasive developmental disorder-not otherwise specified (PDD-NOS)(Baltussen, Clijsen, Leenders 2003). Individuals with an ASD can be characterized by impairment in social relationships, atypical verbal and non-verbal communication, difficulties wit ...
Haseman, J.; (1970)The genetic analysis of quantitative traits using twin and sib data."
... hood procedure is given for estimating the linkage between two marker genes from sib pair data only, i.e., no information is available as to the phenotypes of the parents. Finally, in Chapter XI, data from Gottesman's (1966) Harvard Twin study are analyzed. ...
... hood procedure is given for estimating the linkage between two marker genes from sib pair data only, i.e., no information is available as to the phenotypes of the parents. Finally, in Chapter XI, data from Gottesman's (1966) Harvard Twin study are analyzed. ...
The phenotypic consequences of MECP2 mutations extend beyond
... mutations, the expressivity of the mutant allele in heterozygous females with balanced X-inactivation patterns indicates that some alleles show X-linked recessive effects, while the mutations found in RTT are dominant acting. These differentially acting alleles also manifest as various phenotypes in ...
... mutations, the expressivity of the mutant allele in heterozygous females with balanced X-inactivation patterns indicates that some alleles show X-linked recessive effects, while the mutations found in RTT are dominant acting. These differentially acting alleles also manifest as various phenotypes in ...
Chapter 2. Left in the Genes - SciTech Connect
... dominant allele. This situation most likely applies to the RL heterozygotes with only one R allele and, therefore, a weaker genetic tendency to display right-handedness. To account for the actual handedness patterns in families, geneticists argue that the handedness phenotype is not a direct express ...
... dominant allele. This situation most likely applies to the RL heterozygotes with only one R allele and, therefore, a weaker genetic tendency to display right-handedness. To account for the actual handedness patterns in families, geneticists argue that the handedness phenotype is not a direct express ...
Creative Activities in Music – A Genome
... music, historical creativity considers, for example, composers whose compositions are widely known. However, creative activities in music can also be small-scale individual activities. We have studied self-reported creative activities in music that can be considered as individual-level musical creat ...
... music, historical creativity considers, for example, composers whose compositions are widely known. However, creative activities in music can also be small-scale individual activities. We have studied self-reported creative activities in music that can be considered as individual-level musical creat ...
COPYRIGHTED MATERIAL
... 2001) for dimensional measures of pathological personality and categorical personality disorder diagnoses, It is important to note that most heritability estimates of personality traits are “additive,” that is the contributions of many genes of small effect “add up” in their influence on phenotypic ...
... 2001) for dimensional measures of pathological personality and categorical personality disorder diagnoses, It is important to note that most heritability estimates of personality traits are “additive,” that is the contributions of many genes of small effect “add up” in their influence on phenotypic ...
journals - the biopsychology research group
... distribution of ADHD symptoms in siblings related to ADHD clinical cases defined by diagnostic interviews. We test the hypothesis that siblings of ADHD probands will show similar sibling correlations to those reported in dizygotic twins from population samples. We also test whether an overall shift ...
... distribution of ADHD symptoms in siblings related to ADHD clinical cases defined by diagnostic interviews. We test the hypothesis that siblings of ADHD probands will show similar sibling correlations to those reported in dizygotic twins from population samples. We also test whether an overall shift ...
Psychiatric and physical comorbidity in adults with autism spectrum
... Asperger’s syndrome were statistically more likely to be diagnosed with a comorbid psychiatric illness, most commonly obsessive compulsive disorder. Eighty-four percent of participants had a history of physical illness, most frequently asthma followed by head injury. Sleep difficulties and eating di ...
... Asperger’s syndrome were statistically more likely to be diagnosed with a comorbid psychiatric illness, most commonly obsessive compulsive disorder. Eighty-four percent of participants had a history of physical illness, most frequently asthma followed by head injury. Sleep difficulties and eating di ...
Paper plan: critical issues that need to be overcome on the way to
... common and partly specific across different types of phobias (17). Studies examining the overlap between different types of anxiety have also highlighted an overlap between genes influencing different types of anxiety (for a study of anxiety-related behaviours in pre-school twins see 5), although su ...
... common and partly specific across different types of phobias (17). Studies examining the overlap between different types of anxiety have also highlighted an overlap between genes influencing different types of anxiety (for a study of anxiety-related behaviours in pre-school twins see 5), although su ...
x-linked female-sterile loci in drosophzla melanogaster
... indicating that these gene functions are also required for viability. Most of these loci are represented by only one female-sterile allele; however, there are three exceptions: fused, rudimentary and fs( I)h, in which multiple alleles have been isolated. In the case of fused and rudimentary, most mu ...
... indicating that these gene functions are also required for viability. Most of these loci are represented by only one female-sterile allele; however, there are three exceptions: fused, rudimentary and fs( I)h, in which multiple alleles have been isolated. In the case of fused and rudimentary, most mu ...
Lesson Overview - Enfield High School
... plant alkaloids, tobacco smoke, and environmental pollutants. Physical mutagens include some forms of electromagnetic radiation, such as X-rays and ultraviolet light. ...
... plant alkaloids, tobacco smoke, and environmental pollutants. Physical mutagens include some forms of electromagnetic radiation, such as X-rays and ultraviolet light. ...
Mendel`s Accountant: A New Population Genetics Simulation Tool
... part is used to encode the mutation’s location in the genome. The modulo function is employed to extract an integer from which the mutation’s fitness effect can readily be computed, while a single multiplication yields the mutation’s location in the genome in terms of the linkage subunit on which the ...
... part is used to encode the mutation’s location in the genome. The modulo function is employed to extract an integer from which the mutation’s fitness effect can readily be computed, while a single multiplication yields the mutation’s location in the genome in terms of the linkage subunit on which the ...
De novo mutations in human genetic disease
... Importantly, all of these rates are strongly influenced by factors such as parental sex, age and ethnicity (BOX 1). In addition, the presence of genetic risk factors — such as inversions, duplications, translocations and mutations in genes affecting DNA repair or recombination — may increase these m ...
... Importantly, all of these rates are strongly influenced by factors such as parental sex, age and ethnicity (BOX 1). In addition, the presence of genetic risk factors — such as inversions, duplications, translocations and mutations in genes affecting DNA repair or recombination — may increase these m ...
handedness - UNIT NAME
... Bishop (2001) used data from 2 twin studies to address 2 related questions. First, is there any association between handedness and specific speech and language impairment (SSLI) in children? Second, is there genetic influence on individual differences in handedness, and, if so, are the same genes im ...
... Bishop (2001) used data from 2 twin studies to address 2 related questions. First, is there any association between handedness and specific speech and language impairment (SSLI) in children? Second, is there genetic influence on individual differences in handedness, and, if so, are the same genes im ...
Suggestive Association With Ocular Phoria at Chromosome 6p22
... one for being a population outlier. The genetic data from 988 participants were used in the GWAS. Genotyped SNPs were excluded from the analysis if genotypes were missing for more than 2% of individuals (12,706 SNPs), or if the minor allele frequency was below 1% (77,738 SNPs). After excluding these ...
... one for being a population outlier. The genetic data from 988 participants were used in the GWAS. Genotyped SNPs were excluded from the analysis if genotypes were missing for more than 2% of individuals (12,706 SNPs), or if the minor allele frequency was below 1% (77,738 SNPs). After excluding these ...
Properties of spontaneous mutations affecting quantitative traits
... disregarded control. Therefore, these data should be accepted with caution. Putting together results from such diverse species is speculative, involving too many unknowns, but the exercise is worthwhile. This can be done by adjusting different fitness results so that they can be compared with those ...
... disregarded control. Therefore, these data should be accepted with caution. Putting together results from such diverse species is speculative, involving too many unknowns, but the exercise is worthwhile. This can be done by adjusting different fitness results so that they can be compared with those ...
KaryoNIM Postnatal EN
... chromosomal variations, including the 500 regions of the genome described and accepted by the ISCA consortium. Furthermore, this microarray also includes the possibility of detecting regions with loss of heterozygosity due to uniparental disomy (UPD). This platform is especially indicated for detect ...
... chromosomal variations, including the 500 regions of the genome described and accepted by the ISCA consortium. Furthermore, this microarray also includes the possibility of detecting regions with loss of heterozygosity due to uniparental disomy (UPD). This platform is especially indicated for detect ...
XYY Syndrome - Society for the Study of Behavioural Phenotypes
... XYY males underachieve despite their social background. Many boys require speech therapy and special education. Reading may be particularly affected. Educational performance may be more adversely affected than what would be expected based on IQ measures alone. Difficulties with attention and impulse ...
... XYY males underachieve despite their social background. Many boys require speech therapy and special education. Reading may be particularly affected. Educational performance may be more adversely affected than what would be expected based on IQ measures alone. Difficulties with attention and impulse ...
ppt
... phenotypic trait to isolate a region that influences the trait. In addition, the strength of the relationship (the amount of phenotypic variance explained by differences in genotypes), describes the strength of the gene’s effect. ...
... phenotypic trait to isolate a region that influences the trait. In addition, the strength of the relationship (the amount of phenotypic variance explained by differences in genotypes), describes the strength of the gene’s effect. ...
PDF-729K - ScienceCentral
... Therefore, the estimated prevalence of stuttering is about 1% in the general population. Consistent evidence for the involvement of genetic factors in stuttering has motivated studies aimed at identifying causative genetic mutations that could reveal underlying molecular and cellular deficits in thi ...
... Therefore, the estimated prevalence of stuttering is about 1% in the general population. Consistent evidence for the involvement of genetic factors in stuttering has motivated studies aimed at identifying causative genetic mutations that could reveal underlying molecular and cellular deficits in thi ...
Heritability of autism
The heritability of autism is the proportion of autism that can be explained by genetic variation; if the heritability of a condition is high, then the condition is considered to be primarily genetic. Autism has a strong genetic basis, although the genetics of autism is complex and it is unclear whether autism spectrum disorder (ASD) is explained more by multigene interactions or by rare mutations with major effects.Early studies of twins estimated the heritability of autism to be more than 90%--meaning that 90% of the differences between autistic and non-autistic individuals was due to genetics. This may be an overestimate: new twin data and models with structural genetic variation are needed. When only one identical twin is autistic, the other often has learning or social disabilities. For adult siblings, the risk of having one or more features of the broader autism phenotype might be as high as 30%, much higher than the risk in controls.Genetic linkage analysis has been inconclusive; many association analyses have had inadequate power. For each autistic individual, mutations in more than one gene may be implicated. Mutations in different sets of genes may be involved in different autistic individuals. There may be significant interactions among mutations in several genes, or between the environment and mutated genes. By identifying genetic markers inherited with autism in family studies, numerous candidate genes have been located, most of which encode proteins involved in neural development and function. However, for most of the candidate genes, the actual mutations that increase the risk for autism have not been identified. Typically, autism cannot be traced to a Mendelian (single-gene) mutation or to single chromosome abnormalities such as fragile X syndrome or 22q13 deletion syndrome.The large number of autistic individuals with unaffected family members may result from copy number variations (CNVs)—spontaneous alterations in the genetic material during meiosis that delete or duplicate genetic material. Sporadic (non-inherited) cases have been examined to identify candidate genetic loci involved in autism. A substantial fraction of autism may be highly heritable but not inherited: that is, the mutation that causes the autism is not present in the parental genome.Although the fraction of autism traceable to a genetic cause may grow to 30–40% as the resolution of array CGH improves, several results in this area have been described incautiously, possibly misleading the public into thinking that a large proportion of autism is caused by CNVs and is detectable via array CGH, or that detecting CNVs is tantamount to a genetic diagnosis. The Autism Genome Project database contains genetic linkage and CNV data that connect autism to genetic loci and suggest that every human chromosome may be involved. It may be that using autism-related subphenotypes instead of the diagnosis of autism per se may be more useful in identifying susceptible loci.