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Chapter 12
MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
1) If cells in the process of dividing are subjected to colchicine, a drug that interferes with the formation of the spindle
apparatus, at which stage will mitosis be arrested?
A) anaphase
B) interphase C) telophase
D) prophase
E) metaphase
2) If there are 20 centromeres in a cell at anaphase, how many chromosomes are there in each daughter cell following
cytokinesis?
A) 20 B) 30 C) 40 D) 80 E) 10
3) What is a cleavage furrow?
A) the separation of divided prokaryotes
B) the space that is created between two chromatids during anaphase
C) the metaphase plate where chromosomes attach to the spindle
D) a ring of vesicles forming a cell plate
E) a groove in the plasma membrane between daughter nuclei
4) The cyclin component of MPF is destroyed toward the end of which phase?
A) G2 B) S
C) G1 D) G0 E) M
5) Why do chromosomes coil during mitosis?
A) to increase their potential energy
B) to provide for the structure of the centromere
C) to allow the chromosomes to move without becoming entangled and breaking
D) to allow the sister chromatids to remain attached
E) to allow the chromosomes to fit within the nuclear envelope
6) Besides the ability of some cancer cells to overproliferate, what else could logically result in a tumor?
A) inability to form spindles
B) metastasis
C) changes in the order of cell cycle stages
D) lack of appropriate cell death
E) inability of chromosomes to meet at the metaphase plate
7) During which phase of mitosis do the chromatids become chromosomes?
A) prophase
B) metaphase C) cytokinesis D) anaphase
E) telophase
8) For a chemotherapeutic drug to be useful for treating cancer cells, which of the following is most desirable?
A) It does not alter metabolically active cells.
B) It is safe enough to limit all apoptosis.
C) It interferes with cells entering G0.
D) It only attacks cells that are density dependent.
E) It interferes with rapidly dividing cells.
9) Proteins that are involved in the regulation of the cell cycle, and that show fluctuations in concentration during the cell
cycle, are called
A) kinetochores.
B) proton pumps.
C) ATPases.
D) cyclins.
E) kinases.
10) All cell cycle checkpoints are similar in which way?
A) They give the go-ahead signal to progress to the next checkpoint.
B) They respond to the same cyclins.
C) They utilize the same Cdks.
D) They activate or inactivate other proteins.
E) They each have only one cyclin/Cdk complex.