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Concept check
Concept check
Concept check
Look at the following pedigree of the family. Here the trait is expressed only in
males. Do you think that the inheritance is Y linked? Explain with proper reason.
What could be the alternate possible mode of inheritance?
Predict the genotype of individuals A, B, C and D.
In both a & b males are affected. Are both follow same pattern of inheritance? Or
different ? Give valid justification
Concept check
a) An enzyme X isolated from a eukaryotic cell has 192
amino acid residues and is coded by a gene with 1,440bp.
Explain the relationship between the number of amino
acid residues in the enzyme and the number of nucleotide
pairs in its gene
b) The b-globin gene has three exons of 140, 222 and 252
nucleotides and two introns of 130 and 850 nucleotides,
using this information/data calculate the amino acids
present in the polypeptide that the mature mRNA can
encode?
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Concept check
A nucleotide analog X with the following chemical
structure is present in abundance in a cell infected by HIV.
This analog X blocks DNA chain elongation when it is
incorporated into viral DNA synthesized by reverse
transcriptase. Why does DNA synthesis stop?
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Concept check
Dr. Garrod’s finding on disease ‘Alkaptonuria’ was very
significant due to the following reason. Choose most
appropriate one.
a. He showed that the patients are not victim of ‘black
magic’
b.He showed that the ‘Alkaptonuria’ is not a major
disease, patients can live with it
c. He showed that genetic inheritance is connected to
biochemical pathways in the body
d.He proposed that first cousin marriage is wrong. No
religion should encourage it.
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The prokaryotic cells possess circular DNA as genetic
material. Therefore, in the course of replication, they will
not lose any genetic material as the cell divides. A
eukaryotic cell having linear DNA as genetic material has a
great probability of losing the information at ends of the
DNA strand during replication. How has the eukaryotic
cell evolved to overcome the loss of genetic matter in
subsequent cycles of replication?
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Concept check
The discovery of reverse transcriptase has impact on life in and out of science in a
myriad of ways. This enzyme has proved to be catalyzing the formation of
(a) polypeptide from an RNA template
(b) DNA from a polypeptide template
(c) RNA from a polypeptide template
(d) RNA from a DNA template
(e) DNA from an RNA template
On the basis of the given sequence of DNA
and the resulting protein produced in a
eukaryotic cell, Determine the sequence of
the mRNA (pre-processing and postprocessing)
(Note: shaded region is the promoter for
the gene)
DNA sequence
5’CTGAGACTGCTCCGCCTCGCCATGACTATAACTGCTATCCTACAGCAGCATCGGATATCGCCAGTCGTCGGCCTAA3’
3’GACTCTGACGAGGCGGAGCGGTACTGATATTGACGATAGGATGTCGTCGTAGCCTATAGCGGTCAGCAGCCGGATT 5
’
Protein
MethionineThreonineSerineTyrosineTyrosineArginineGlutamineSerineSerineAlanine-
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On the basis of the given sequence of DNA
and the resulting protein produced in a
eukaryotic cell, Determine the sequence of
the mRNA (pre-processing and postprocessing)
(Note: shaded region is the promoter for
the gene)
DNA sequence
5’CTGAGACTGCTCCGCCTCGCCATGACTATAACTGCTATCCTACAGCAGCATCGGATATCGCCAGTCGTCGGCCTAA3’
3’GACTCTGACGAGGCGGAGCGGTACTGATATTGACGATAGGATGTCGTCGTAGCCTATAGCGGTCAGCAGCCGGATT 5’
mRNA (preprocessed)
5’AUGACU
UAUCGCCAGUCGUCGGCCUAA3’
UCCUAC
mRNA (postprocessing)
5’
GMAUG ACU UCC UAC UAU CGC CAG UCG UCG GCC UAA AAA(n)3’
Met Thr
Ser Tyr
Tyr Arg
Glu Ser
Ser
Ala Stop
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