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1859 1663 10000 20000 B.C. 1797 Robert Hooke describes the first cell. Early Biotechnology Culitvation of crops & domestic animals, wine & cheese produced. Zacharias Janssen discovers first microscope. 10000 B.C. 1590 Edward Jenner uses cowpox to vaccinate against smallpox. Anton von Leeuwenhoek observes bacteria & protozoa. 1675 1917 Charles Darwin publishes “On the Origin of Species”. Principles of natural selection leads to Evolution Theory. Matthias Schleiden, Theodore Shawnn develop the Cell Theory. All living things are made of cells. 1838 1839 1863 Gregor Mendel discovers principles of how traits are passed from parents to offspring. Louis Pasteur proposes the Germ Theory, pasteurization and discovers rabies vaccine. 1861 1885 1944 First use of the word “Biotechnology”. Thomas Hunt Morgan proposes genes are located on chromosomes. 1986 1960s Avery, MacLeod & McCarty discover DNA is the hereditary material. Alexander Fleming discovers the antibiotic penicillin. Watson & Crick describe the structure of DNA. 1953 1915 1928 Stem Cell research blood and bone marrow. 1973 FDA approves genetically engineered insulin. 1982 2001 Dolly is cloned. Human Genome Project launced to map human genes. Nanotechnology is coined by Noiro Tanuchi of Japan. The manipulation of atoms & molecules 10 -9 . Stanley Cohen & Herbert Boyer cut and paste DNA from 2 different organismsRecombinant DNA Science. 1990 FDA approves Hepatitis B vaccine. 1974 2003 1996 FDA approves first enzyme as a food substance chymosin used for cheese. 1990 FDA approves first genetically engineered crop FLAVR SAVR tomato. CC “Carbon Copy” cloned kitten. James Thompson develops embryonic stem cell line. 1994 Completion of Human Genome Project bioinformatics & proteomics. Glofish first genetically modified pet. FDA approves vaccine against cervical cancer. 2003 1998 2006 Biotechnology Timeline BIOTECHNOLOGY BETTER LIVING THROUGH SCIENCE INNOVATION