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Transcript
SGUL/LSHTM MRC London Intercollegiate Doctoral Training Partnership – 2017/18 Potential PhD Projects Title of PhD project Horizontal gene transfer of antimicrobial resistance in pathogens of clinical importance Supervisor Prof Jodi Lindsay SGUL Co-Supervisor Dr Adam Witney SGUL Brief description of project Antimicrobial resistance (AMR) is the greatest threat to modern medicine (amr-review.org/Publications). Resistant bacteria exchange AMR genes with other bacteria by horizontal gene transfer mechanisms – “bacterial sex”. Our recent studies have suggested that the important AMR pathogen methicillin-resistant Staphylococcus aureus (MRSA) acquires AMR genes at very high frequency as it colonizes the host, but also loses resistances frequently. We have now built laboratory models to investigate how this gene transfer occurs, how it is regulated, whether we can encourage resistance gene loss and how AMR populations evolve. These studies will be extended to include other important hospital-acquired infections and clinically important AMR pathogens from patients in our hospital. The aim is to better diagnose, predict and control the evolution of AMR pathogens under selective pressures in the host. Particular prior educational requirements for a student undertaking this project Standard institution research degree entry requirements. Skills we expect a student to develop/acquire whilst pursuing this project The PhD student will develop and manipulate laboratory bacteriology models, and genetically investigate evolving populations in these models and in patient samples using molecular methods and whole genome sequencing. Training in all aspects including microbiology, genetic, genomic and bioinformatics skills will be provided. This is a multidisciplinary project with translational relevance to benefit patients, and the opportunity to interact with a wide variety of experts in diagnostics, big data, epidemiology and public health. 1
