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B.Sc (H) III Year ( Semester V) Paper Title- Immunology (ZOHT-507) Teachers - Mrs Rigzin Kang (classes per week: 3; Units to be taught:1, 3(organs of immune system), 4, 5(antigen antibody interactions), 6,7,8,9) Dr Gaganjot Singh (Classes per week: 2; Units to be taught: 2, 3 (Hematopoeisis, Cells of immune system), 5 ( all topics excluding Ag-Ab interactions), 10) Rigzin Kang Week Topics Covered Objective 21stUnit 1-Overview of Introduction to the th 24 immune system concept of July immunology and its historical perspective. Study of timeline of important discoveries Gaganjot Singh Topics Covered Introduction, scope and importance of Immune System 25th31st July Unit 3- Cells and Organs of Immune System 1st 7th Aug Overview of immune system(contd) Early theories of immunology Unit 4- Antigens Introduction and Properties Study of antigen properties and factors affecting antigen action Haptens Epitopes Understanding importance of haptens with examples of relevant experiments. Understanding of B and T cell epitopes with examples Unit 2- Components of Immune system Natural, Innate and Acquired immunity Immune responsiveness Introduction Diversity of Cells in immune system Physiological and Anatomical Barriers Primary and Secondary Immune response Composition of Blood Reticuloendothelial System Lymphatic System Cytology, Histology and Functions of Dendritic Cells, Neutrophils/ Microphages/ PMNL, Macrophages, Monocytes, Eosinophils and Basophils Opsonins and Opsonization Objective To understand basics of mechanisms underlying immunity Understanding differences between primary and secondary immune responses. . Role of blood and lymph and their components with respect to immunity Classification of cellular components of immune system and their mode of action and cellular details 14th 21st Aug Concepts in antigen antibody interaction 21st – 28th Aug Unit 5- Antibodies Antigen antibody interaction 29th Aug – 4th Sept Unit 7- Antigen processing and presentation Endogenous pathway 5th 11th Sept 12th– 18th Sept Summary Unit 6- Major Histocompatibility Complex MHC complex 19th– 25th Sept Exogenous pathway Exogenous pathway In depth understanding of concepts like avidity, affinity, cross reactivity etc with relevant examples Bone Marrow, Thymus Thymic Selection Spleen, Lymph Nodes MALT, GALT, BALT, CALT Study of concepts of agglutination, immunoprecipitation, radioimmunoassay, immunofluorescence, ELISA etc Lymphocytes,B – Cells, Plasma Cells, T – Cells, NK Cells Revision / Summary Understanding of the cells, substances and processes involved in endogenous or cytosolic pathway of antigen presentation Understanding of the cells, substances... .... and processes involved in exogenous or endocytic pathway of antigen presentation. Summary of chapter and linkage with concepts learnt earlier Study of components and importance of MHC complex. Class I MHC Study of structure of Class I MHC Molecule molecules and their interaction with Tc cells and Antigen Study of structure of Class II MHC Class II MHC molecule molecules and their interaction with Th cells and Antigen Classification of organs and tissues as components of immune system and their mode of action and cellular details Understanding of variety of lymphocytes and their role in humoral and cell mediated immunity Unit 5- Immunoglobulins Types Discovery of Immunoglobins Classical Experiments of Tiselius and Kabat Understanding of experiments leading to discovery of Igs Classification of Antibodies Composition of antibody molecules Production Cycle of antibodies Types of antibodies, their production and experiments leading to deciphering of structure of IgG Introduction: Polyclonal and Monoclonal Serum Experiments Concluding Structures of Immunoglobulins Fine structure of Antibody Molecular determinants on IgG IgG Domains -do- Understanding molecular structure of IgGs 26th Sept – 2nd Oct 3rd – 9th Oct 10th – 16th Oct 17th – 23rd Oct Relevance of MHC Unit 8- Immune Effector Mechanisms Cytokines Complement system Understanding of MHC polymorphism and its relevance Understanding of basic types and functions of important cytokines Study of components involved in complement action; In depth study of three... Complement System (contd) ...types of complement pathways; functions and regulation of complement system. Applications of Immunoglobins in research and Medical practices Revision/ Summary Understanding applications of Immunoglobins..... ..... and their mass production systems Unit 10- Vaccines Gel and Coombs classification Mechanism of hypersensitivity Type 1, 2, 3, 4 hypersensitivity Summary and overview of all topics Introduction History of Vaccination, Classical Experiments by Pasteur and Jenner Herd Immunity Need for vaccines Types of vaccines Unit 9- Hypersenstivity 31st Oct – 6th Nov 7th13th Nov Avidity, Affinity, Role in Opsonization, Target Neutralization Polyclonal Antibodies Monoclonal Antibodies Hybridoma Technology Mid Semester Break 24th 30th Oct Differences between Class of antibodies Sequential Humoral Immune response Understanding concept of heightened immune response Classification and study of various types of hypersensitivities DNA Vaccines, Recombinant Vaccines, Vector based Vaccines Attenuated Bacterial, Viral and Toxoids Chimaeras Discussion of Assignments on Vaccines Revision/ Summary Summary and overview of all topics Understanding historical perspective of vaccination and their importance in current scenario Types of Vaccination Their efficacies and mechanism of production and action