Download - SGTB Khalsa College

B.Sc (H) III Year ( Semester V)
Paper Title- Immunology (ZOHT-507)
Teachers - Mrs Rigzin Kang (classes per week: 3; Units to be taught:1, 3(organs of immune
system), 4, 5(antigen antibody interactions), 6,7,8,9)
Dr Gaganjot Singh (Classes per week: 2; Units to be taught: 2, 3 (Hematopoeisis, Cells of
immune system), 5 ( all topics excluding Ag-Ab interactions), 10)
Rigzin Kang
Week Topics Covered
Objective
21stUnit 1-Overview of
Introduction to the
th
24
immune system
concept of
July
immunology and its
historical
perspective.
Study of timeline of
important discoveries
Gaganjot Singh
Topics Covered
Introduction, scope and
importance of Immune System
25th31st
July
Unit 3- Cells and Organs of
Immune System
1st 7th
Aug
Overview of immune
system(contd)
Early theories of
immunology
Unit 4- Antigens
 Introduction and
Properties
Study of antigen
properties and
factors affecting
antigen action


Haptens
Epitopes
Understanding
importance of
haptens with
examples of relevant
experiments.
Understanding of B
and T cell epitopes
with examples
Unit 2- Components of
Immune system
Natural, Innate and Acquired
immunity
Immune responsiveness



Introduction
Diversity of Cells in
immune system
Physiological and
Anatomical Barriers

Primary and
Secondary Immune
response

Composition of Blood
Reticuloendothelial
System
Lymphatic System




Cytology, Histology and
Functions of Dendritic
Cells, Neutrophils/
Microphages/ PMNL,
Macrophages,
Monocytes,
Eosinophils and
Basophils
Opsonins and
Opsonization
Objective
To understand
basics of
mechanisms
underlying
immunity
Understanding
differences
between primary
and secondary
immune
responses.
.
Role of blood and
lymph and their
components with
respect to
immunity
Classification of
cellular
components of
immune system
and their mode of
action and cellular
details
14th 21st
Aug

Concepts in
antigen antibody
interaction
21st –
28th
Aug
Unit 5- Antibodies
Antigen antibody
interaction
29th
Aug –
4th
Sept
Unit 7- Antigen
processing and
presentation
 Endogenous
pathway

5th 11th
Sept


12th–
18th
Sept
Summary
Unit 6- Major
Histocompatibility
Complex
 MHC complex

19th–
25th
Sept
Exogenous
pathway
Exogenous
pathway

In depth
understanding of
concepts like avidity,
affinity, cross
reactivity etc with
relevant examples




Bone Marrow, Thymus
Thymic Selection
Spleen, Lymph Nodes
MALT, GALT, BALT,
CALT
Study of concepts of
agglutination,
immunoprecipitation,
radioimmunoassay,
immunofluorescence,
ELISA etc

Lymphocytes,B – Cells,
Plasma Cells, T – Cells,
NK Cells

Revision / Summary
Understanding of the
cells, substances and
processes involved in
endogenous or
cytosolic pathway of
antigen presentation
Understanding of the
cells, substances...
.... and processes
involved in
exogenous or
endocytic pathway of
antigen presentation.
Summary of chapter
and linkage with
concepts learnt
earlier
Study of components
and importance of
MHC complex.
Class I MHC Study of structure of
Class I MHC
Molecule
molecules and their
interaction with Tc
cells and Antigen
Study of structure of
Class II MHC
Class II MHC
molecule
molecules and their
interaction with Th
cells and Antigen
Classification of
organs and tissues
as components of
immune system
and their mode of
action and cellular
details
Understanding of
variety of
lymphocytes and
their role in
humoral and cell
mediated
immunity
Unit 5- Immunoglobulins











Types
Discovery of
Immunoglobins
Classical Experiments
of Tiselius and Kabat
Understanding of
experiments
leading to
discovery of Igs
Classification of
Antibodies
Composition of
antibody molecules
Production Cycle of
antibodies
Types of
antibodies, their
production and
experiments
leading to
deciphering of
structure of IgG
Introduction:
Polyclonal and
Monoclonal Serum
Experiments
Concluding Structures
of Immunoglobulins
Fine structure of
Antibody
Molecular
determinants on IgG
IgG Domains
-do-
Understanding
molecular
structure of IgGs

26th
Sept
– 2nd
Oct
3rd –
9th
Oct
10th –
16th
Oct
17th –
23rd
Oct

Relevance of
MHC
Unit 8- Immune Effector
Mechanisms

Cytokines

Complement
system
Understanding of
MHC polymorphism
and its relevance
Understanding of
basic types and
functions of
important cytokines
Study of components
involved in
complement action;
In depth study of
three...









Complement
System (contd)
...types of
complement
pathways; functions
and regulation of
complement system.
Applications of
Immunoglobins in
research and Medical
practices
Revision/ Summary
Understanding
applications of
Immunoglobins.....
..... and their mass
production
systems
Unit 10- Vaccines




Gel and Coombs
classification
Mechanism of
hypersensitivity
Type 1, 2, 3, 4
hypersensitivity
Summary and overview
of all topics
Introduction
History of Vaccination,
Classical Experiments
by Pasteur and Jenner
Herd Immunity
Need for vaccines
Types of vaccines

Unit 9- Hypersenstivity

31st
Oct –
6th
Nov
7th13th
Nov
Avidity, Affinity, Role in
Opsonization, Target
Neutralization
Polyclonal Antibodies
Monoclonal Antibodies
Hybridoma Technology
Mid Semester Break



24th 30th
Oct
Differences between
Class of antibodies
Sequential Humoral
Immune response
Understanding
concept of
heightened immune
response
Classification and
study of various
types of
hypersensitivities
DNA Vaccines,
Recombinant Vaccines,
Vector based Vaccines
 Attenuated Bacterial,
Viral and Toxoids
 Chimaeras
Discussion of Assignments on
Vaccines
Revision/ Summary
Summary and overview of all
topics
Understanding
historical
perspective of
vaccination and
their importance
in current
scenario
Types of
Vaccination
Their efficacies
and mechanism of
production and
action