Download March 2011 QUESTION 20 Describe how previous

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Transcript
March 2011
QUESTION 20
Describe how previous immunisation protects against subsequent
infection
Immune system
Is characterised by
recognition
effector responses
memory
Is functionally divided into two interellated components
innate immunity
adaptive immunity
Vaccine
is the process of stimulating protective adaptive immune responses against pathogens
it is done by introducing nonpathogenic forms or components of these pathogens
this induces an immune response and creates memory of the matching epitopes
Adaptive immunity
humoral (in the body fluids)
cell mediated
both are involved in development of memory
antigen introduced
Recognition
attaches to antigen presenting cell
APC binds to CD4 T Cell via TLR - MHC 2
Effector responses
Humoral response
T-Cell activates
B Lymphocyte is activated
Cell mediated response
activation of cytotoxic
CD8 T Cells which bind to MHC 1
on antigenic cells
Plasma cell produces
immunoglobulins
IgG and IgM
attach to antigens
instigate responses
Memory
memory immunoglobulins
persist (IgG)
memory T Cells
persist
Subsequent infection is characterised by a much more rapid recognition memory T cells and IgG recognise the
antigen and develop a rapid and specific effector response to the antigen
Christopher Andersen 2012