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# ______
NAME: ___________________________________________________
BIOTECHNOLOGY
DATE: _____________________________
Learning Goals: Students will understand…
1.
2.
Main Idea/Side Comments/Questions to consider:
Notes: Highlight key vocabulary words in yellow, underline SVO then draw a box around
only those sentences that contain the main ideas of each paragraph.
Welcome to the Virtual Transgenic Fly Lab. The lab will familiarize you
with the science and techniques used to make transgenic flies.
Transgenic organisms, which contain DNA that is inserted experimentally,
are used to study many biological processes. In this lab, you will create a
transgenic fly to study circadian rhythms. The fly glows only when a
certain gene involved in circadian rhythms is activated. After making the
glowing fly, you will use it to explore basic principles of circadian biology
and genetics.
The period gene is a key component of the fly's molecular clock The
period (or per) gene's transcription and translation oscillate in a regular
pattern that has a period of 24 hours. A mutation in this gene results in a
fly with an altered period; the name period was therefore given to this
gene. This predictable pattern is harnessed in the experiments here to
provide a window into how clock molecules change. Specifically, part of
the period gene is linked to the luciferase gene (per-luc) such that
whenever the period gene is "on," light is produced in the cells where
period gene transcription is occurring. This elegant model allows us to
look at changes in genes simply by looking at the glow of these transgenic
flies.
2. Use transgenic flies to study circadian rhythms and genetics.
o
Measure per-luc gene expression (that is, light emissions)
under different light-dark conditions.
o
Examine different fly body parts for per-luc expression.
Modified from the HHMI BioInteractive website. Available at:
http://www.hhmi.org/biointeractive/vlabs/transgenic_fly/content/intro.html
Summarize today’s lesson either in your words (best) or by copying the simplified SVO underlined in the text above:
# ______
NAME: ___________________________________________________
BIOTECHNOLOGY
DATE: _____________________________
Instructions: Record the highlighted key vocabulary words from the previous page. Using context clues, try to define the word in your own words. We
will check your definitions tomorrow.
Word
Definition (Your Own Words)
Picture