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Edexcel Biology B Topic 1 – Biological Molecules –
Diagnostic test (DTT)
1.
Question
Topic
Mark
1-2
Minerals /water
/2
3-6
Amino acids/Proteins
/4
7-8
Lipids
/2
9-12
Carbohydrates
/4
13-24
DNA/Replication/Transcription/Translation
/12
25-30
Enzymes/Enzyme inhibition
/6
Carbon, hydrogen, nitrogen and sulphur are elements found in living cells. Which is the least
common?
A.
Carbon
B.
Hydrogen
C.
Nitrogen
D.
Sulphur
(Total 1 mark)
2.
Which of the following features are correct for hydrogen bonding?
I.
It is involved in the cohesion of water.
II.
It results in the thermal properties of water.
III.
It is a bond within the water molecule.
A.
I and II only
B.
II and III only
C.
I and III only
D.
I, II and III
(Total 1 mark)
1
3.
Which of the following reactions occurs when a dipeptide is formed from amino acids?
A.
Hydrolysis
B.
Denaturation
C.
Condensation
D.
Oxidation
(Total 1 mark)
4.
Which diagram correctly illustrates a dipeptide?
A.
H
N
C.
O
H
H
C
C
N
C
H
H
H
H
H
C
C
N
H
5.
H
O
H
C
N
H
OH
H
H
O
N
C
H
B.
D.
H
H
C
C
N
C
H
H
H
O
C
C
N
OH
O
H
C
H
H
H
O
C
H
OH
H
H
O
N
C
H
C
OH
(Total 1 mark)
H
Which structure represents an amino acid?
A.
N
H
C.
C
O
N
C
OH
N
H
H
D.
H
H
H
C
H
H
H
B.
H
H
O
H
SH
H
N
H
C
OH
H
C
C
O
C
H
O
C
OH
(Total 1 mark)
2
6.
Which is not a primary function of protein molecules?
A.
Hormones
B.
Energy storage
C.
Transport
D.
Structure
(Total 1 mark)
7.
What is the maximum number of fatty acids that can be condensed with glycerol?
A.
One
B.
Two
C.
Three
D.
Four
(Total 1 mark)
8.
Which is the structure of glycerol?
A.
H
H
H
H
C
C
C
B.
H
H
OH OH OH
C.
H
H
H
C
C
OH OH
D.
H
H
H
H
H
C
C
C
H
H
OH
H
H
C
C
H
OH
H
H
(Total 1 mark)
3
9.
Which of the following diagrams is the structure of ribose?
A.
O
HOH 2C
C.
H
H
C
C
OH
OH
C
H
OH
C
OH
O
HOH 2C
D.
OH
H
OH
C
OH
O
H
H
C
OH
H
C
C
H
OH
HOH2 C
C
C
H
CH 2OH
C
C
H
B.
H
OH
O
H
C
C
CH 2OH
H
H
C
C
C
H
OH
H
H
OH
(Total 1 mark)
10.
Which molecule represents ribose?
A.
H
C
O
H
C
H
OH H
C
OH C
H
C.
B.
CH 2 OH
C
O
H
C
H
O
C
H
N
OH
H
OH
D.
H
H 2C
OH
HC
OH
C
H 2C
OH
H
O
HOH 2 C
H
C
H
H
C
C
OH
OH
OH
(Total 1 mark)
4
11.
What is a role of carbohydrates in animal cells?
A.
As channels for passive transport
B.
As enzymes
C.
As energy storage
D.
As components of the animal cell wall
(Total 1 mark)
12.
Which of the following terms correctly describe(s) the molecule above?
I.
Monosaccharide
II.
Glucose
III.
Component of triglyceride
A.
I only
B.
I and II only
C.
II and III only
D.
I, II and III
(Total 1 mark)
5
13.
Which enzyme removes the RNA primer during replication?
A.
RNA primase
B.
DNA polymerase I
C.
DNA ligase
D.
Helicase
(Total 1 mark)
14.
Where is an anti-codon located?
A.
tRNA
B.
mRNA
C.
DNA
D.
Ribosomes
(Total 1 mark)
15.
What is responsible for the conservation of the base sequence during DNA replication?
A.
DNA polymerase working on one strand at the same time.
B.
Unpaired bases always attracting their complementary nucleotides.
C.
DNA helicase and polymerase are complementary.
D.
Both strands are identical to each other.
(Total 1 mark)
6
16.
The diagram below represents a DNA nucleotide. What could the part labelled X represent?
A.
Ribose
B.
Uracil
C.
Guanine
D.
Phosphate
(Total 1 mark)
17.
In an electron micrograph, a DNA molecule appears 1 mm wide. The magnification of the
micrograph is 500 000. What is the width of the DNA molecule?
A.
0.5 nm
B.
2 nm
C.
0.5 m
D.
2 m
(Total 1 mark)
18.
To which parts of the deoxyribose molecule do phosphates bind in DNA?
V
CH2 OH
I
O
H
IV
H
H
H
OH
II
OH
H
III
A.
I and V
B.
III and IV
C.
II and III
D.
III and V
(1)
7
19.
Where do transcription and translation occur in eukaryotic cells?
Transcription
Translation
A.
Cytoplasm
Cytoplasm
B.
Cytoplasm
Mitochondria
C.
Nucleus
Cytoplasm
D.
Nucleus
Nucleus
(1)
20. A biochemist isolated and purified molecules needed for DNA replication. When some DNA
was added replication occurred, but the DNA molecules formed were defective. Each consisted of a
normal DNA strand paired with segments of DNA a few hundred nucleotides long. Which of the
following had been left out of the mixture?
A.
DNA ligase
B.
Helicase
C.
Nucleotides
D.
DNA polymerase
(1)
21.
The diagram below shows a short section of DNA molecule before and after replication. If the
nucleotides used to replicate the DNA were radioactive, which strands in the replicated
molecules would be radioactive?
I
G C T A C
C G A T G
II
G C T A C
C G A T G
III
G C T A C
C G A T G
IV
A.
II and III only
B.
I and III only
C.
I and II only
D.
I, II, III and IV
(Total 1 mark)
8
22.
What is the function of helicase?
A.
It forms bonds between DNA nucleotides.
B.
It adds new nucleotides to the DNA helix.
C.
It forms the DNA helix.
D.
It separates DNA strands.
(Total 1 mark)
23.
Which of the following are connected by a hydrogen bond?
A.
The hydrogen and oxygen atoms of a water molecule
B.
A base pair of a DNA molecule
C.
Two amino acid molecules of a dipeptide
D.
Two glucose molecules in a disaccharide
(Total 1 mark)
24.
What is the composition of the backbone of DNA?
A.
Alternating sugar and phosphate molecules
B.
Complementary base pairs
C.
Alternating sugar and base molecules
D.
A polysaccharide
(Total 1 mark)
9
25. The graph below shows the effect of changing the substrate concentration on an enzyme
controlled reaction.
40 % substrate
20 % substrate
10 % substrate
Amount of product formed
5 % substrate
2.5 % substrate
0 % substrate
Time
What is the correct interpretation of these data?
A.
The rate of reaction increases continuously with increase in substrate concentration.
B.
The rate of reaction decreases continuously with increase in substrate concentration.
C.
The rate of reaction increases up to a point and then remains constant.
D.
The rate of reaction is not affected by any change in the substrate concentration.
(1)
26.
What can reduce the effect of a competitive inhibitor of an enzyme?
A.
Decrease the temperature at which the reaction takes place.
B.
Increase the temperature at which the reaction takes place.
C.
Increase the substrate concentration.
D.
Add a non-competitive inhibitor.
(Total 1 mark)
27. A certain gene codes for a polypeptide that is 120 amino acids long. Approximately how many
nucleotides long is the mRNA that codes for this polypeptide likely to be?
A.
30
B.
40
C.
360
D.
480
(Total 1 mark)
10
28.
Which enzyme removes the RNA primer during replication?
A.
RNA primase
B.
DNA polymerase I
C.
DNA ligase
D.
Helicase
(Total 1 mark)
29.
Consider the metabolic pathway shown below.
1
A
B
2
C
3
D
4
E
If there is end-product inhibition, which product (B to E) would inhibit which enzyme (1 to 4)?
Product
Enzyme
A.
C
4
B.
B
3
C.
B
4
D.
E
1
(Total 1 mark)
30.
Which of the following could cause denaturation of an enzyme?
A.
Substrate concentration
B.
A competitive inhibitor
C.
High temperature
D.
Low salt concentration
(1)
11