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Nile University
The Department of Biology
C&M-111: Cells and Molecules
Module information: 2016-2017
Symbol & name:
Audience:
Prerequisites:
Contact Hours:
Credit Hours:
Duration:
Evaluation:
C&M111, Cells & Molecules
Freshmen, Semester (1)
Medicine Program
None
2, 1-Hour per week lectures
1, 3-Hours per week practical
3 (2+1)
15 weeks
Lab work, records & tests:
Mid semester examination:
Assignment, tutorials & quizzes
End of Semester examination:
Per Lab instructors (10%)
One 1-hour, Theory (20%)
Per instructor (10%)
One 3-hour, Theory (40%)
One 3-hour Practical (20%)
GOALS AND OBJECTIVES
Goals:
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The module introduces the students to major concepts of cell biology: the chemical &
molecular basis of life, with emphasis on the functional contributions to homeostasis
of the cell membranes, intracellular components, and the variety of cells.
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The course provides a fundamental core of knowledge and skills which will
facilitate transition to the next level medical sciences such as Molecular
Genetics, Biochemistry, Physiology, Histology, Oncology, Microbiology, and
Pathology.
Learning Objectives:
Students will:
 Learn the basic rules of working in a biology laboratory, including the proper and
effective use of the microscope and other tools and the safe handling of material.
 Proper attitude and safe dress code while working in a laboratory
 Recognize and prevent harm due to hazards encountered in the laboratory: biological,
chemical & physical
 Know the anatomy of the visible-light microscope, handling, uses and operative
maintenance
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Grasp the basic concepts of the fine structure and function of cells and organelles, and
the different types of cells.
Be familiar with the cell theory as basis for understanding the characteristics of living
things
Describe protoplasm and the architecture of a typical cell (light & electron
microscopy)
Structure, properties and functions of the cell membrane (permeability & electrical
properties); the significance of constant non-equilibrium between the cell and the
interstitial space.DNA structure and configurations: Replication, transcription and
translation; circular DNA, nucleus & nuclear membrane
The nature of organelles and specific operative functions: Ribosomes & protein
synthesis, Mitochondria & energy transactions, the ER, Golgi bodies & vacuoles, the
cytoskeleton
Study the origin of cells (meiosis & mitosis): Sexual reproduction, early embryonic
development, tissue development and regeneration.
The cell cycle, processes & controls, cellular multiplication (binary fission,
conjugation & mitosis) & genetic controls, meiosis & gametogenesis, crossing-over
& Intraspecific genetic diversification
Understand the chemical & molecular mechanisms of life and the importance of
water. The properties of water, Intra- & inter-cellular communication; signal origins,
reception, transduction, & response
Be familiar with the dynamic nature and activities of the cell membranes, and their
contribution to homeostasis and the diversified specific cell functions.
The dynamic architecture of the plasmalemma, selective permeability, diffusion,
osmosis, endocytosis, exocytosis, membrane receptors, MHC, membrane proteins,
channels, electrical properties
Review the structure, replication, and recombination of chromosomes; transcription
& gene regulation, the genetic code, translation, and mutations
DNA structure, replication, transcription, translation, enzyme mechanisms:
helicase/polymerase, intracellular signals, codons
Be knowledgeable of modern advances in applications of molecular biology in the
medical field (Nano-technology & Pharmacogenetics).
COURSE CONTENT:
Lecture topics: (These topics are to be delivered in 15, 11/2 hour lectures.
Topic (1): Course description, characteristics of living things at the cellular &
molecular levels, the relevance of biology to the medical sciences.
Topic (2):
The chemical & cellular basis of life: structure, nomenclature. Biomacromolecules and their monomers & related metabolic processes:
carbohydrates, lipids, proteins and nucleic acids.
Topic (3): The Cell Theory, the Gene Theory, cell multiplication (binary fission,
conjugation, mitosis & meiosis)
Topic (4):
Cellular organization: the structure of a typical cell, the two basic types of
cells, characteristics of eukaryotes in comparison to bacterial cells.
Topic (5): Properties, and physiology of cell membranes; membrane properties,
electrical potential and transport activity.
Topic (6): Cellular communication, chemical & physical signals, signal transduction in
health and disease, signal transduction, and cellular transformation.
Topic (8): Structures and composition of the nucleus, chromosomes, nucleic acids, and
the human genome.
Topic (9): Chromosomal replication and recombination, Transcription, translation,
mutations and gene regulation.
Topic (10): Gametogenesis, fertilization & early embryonic development
Topic (11): The diversity of cells: types of tissue components.
Topic (12): Heredity and Mendelian genetics.
Topic (13): The cell cycle, cell aging, programmed cell death and aberrant cell
development.
Topic (14): Energy harvesting in the cell, autotrophy & heterotrophy, ADP/ATP &
electron transfer, and the role of enzymes & coenzymes in cellular activities.
Topic (16): The principles of tissue culture, genetic engineering and recombinant DNA
technology, nucleic acid manipulations and the PCR method.
Case Studies
Lung cancer, HIV/AIDS, Glycogen storage disease, Down syndrome
(amniocentesis & genetic counselling), Cystic fibrosis, Sickle-cell disease, TaySachs disease, Hemophilia, Phenylketonuria, and Huntington’s disease.
Textbooks:
1. Stansfield, W. D., J. S. Colome and R. J. Cano (1996). “Schaum’s Outline
of Theory and Problems of Molecular and Cell Biology”, McGraw-Hill,
New York, London, Toronto, etc.
2. Raven, Peter H. & George B. Johnson: Biology, ed. 4, Wm. C. Brown
Publishers, London, 1996.
3. Alberts, B., D. Bray, J. Lewis, M. Raff, K. Roberts, and J Watson (1994).
“Molecular Biology of the Cell”, ed. 3, Garland Press, New York.
Nile College: Biology Department
Program: Medicine. Module: …Cells and Molecules: MD C&M 111…
Class/Year: …First Year….
Semester:…… Semester (1)……
Course delivery: Proposed Lectures’ Plan
Staff Coordinators: Uz. Fatma M. Najeeb, M. Sc. & M. Sidahmed Hussein, Ph. D.
Duration: 09 /…November…/2016, to: 22 / February /…2017
Week Day/Date Time
Lecture Topics
1.
Wed
9 Nov
08:30-09:20
09:30-10:20
2.
Wed
16 Nov
08:30-09:20
09:30-10:20
3.
Wed
23 Nov
08:30-09:20
09:30-10:20
4.
Wed
30 Nov
08:30-09:20
09:30-10:20
Module description - Expectations, rules and regulations √
The Characteristics of Living Things √
Water, pH, and Chemistry of living things √
Biological Molecules: introduction √
The Cell: cellular basis of life, the Cell Theory; The general
structures, prokaryotes, eukaryotes. +Organelle functions √
The diversity of cells (Bacteria, plants, fungi, protists &
multicellular animals) √
5.
Wed
07 Dec
08:30-09:20
09:30-10:20
6.
Wed
14 Dec
7.
8.
9.
Room
Lecturer/s
LT 403
M Sidahmed
LT 403
M Sidahmed
LT 403
F Najeeb
LT 403
F Najeeb
The cell cycle and controls, Apoptosis √
LT 403
M Sidahmed
08:30-09:20
09:30-10:20
Cellular multiplication: budding, binary fission, mitosis & meiosis √
LT 403
M Sidahmed
Wed
21 Dec
08:30-09:20
09:30-10:20
The nucleus & Nucleic Acid ; DNA repair & replication √
LT 403
M Sidahmed
Wed
28 Dec
08:30-09:20
09:30-10:20
DNA & transcription, translation & Protein synthesis √
LT 403
Uz. Fatima
Mid-Semester Examinations: 31 December 2016 – 08 January 2017
10.
Wed
08:30-09:20
Proteins + Quiz Lecture 7
11 Jan ‘17 09:30-10:20
LT 403
M Sidahmed
11.
Wed
18 Jan
08:30-09:20
The Cell Membrane: structure & functions
09:30-10:20
LT 403
Prof MYS
12.
Wed
25 Jan
08:30-09:20
Cellular communication in health & disease
09:30-10:20
LT 403
M Sidahmed
13.
Wed
01 Feb
08:30-09:20
1. Inheritance & Mendel’s laws 2. Human Genetic Abnormalities
09:30-10:20
LT 403
M Sidahmed
14.
Wed
8 Feb.
08:30-09:20
Carbohydrates & Lipids
09:30-10:20
LT 403
M Sidahmed
15.
Wed
15 Feb.
08:30-09:20
Energy Transactions in the cell: The mitochondria
09:30-10:20
LT 403
M Sidahmed
16.
Wed
22 Feb.
08:30-09:20
The variety of mammalian tissues; introduction to histology
09:30-10:20
LT 403
M Sidahmed
17.
Pre-exam Break: ……24 Feb. – 3 March, 2017.……………………….
18.
(End of Semester Examinations: 4-23 March, 2017)