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2008-2009 Seminar Series Date Speaker Joint Sponsor Title/Field of Study 10/28/08 Deborah Gumucio, Ph.D. University of Michigan Medical School Dept. of Cell and Developmental Biology Hedgehog signaling in the gut - new links to old responses 11/03/08 Susan Henning, Ph.D. University of North Carolina Dept. of Molecular Physiology and Biophysics The elusive intestinal stem cell: progress and challenges 12/02/08 Cathryn Nagler, Ph.D. Massachusetts General Hospital TLR-mediated signals from intestinal microbes regulate immune responsiveness 01/27/09 Luc Van Kaer, Ph.D. Vanderbilt University Medical Center Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease 02/03/09 Martin Kagnoff, M.D. University of California at San Diego 03/03/09 Shanthi Sitaraman, M.D., Ph.D. Emory University Adenosine 2B receptor: Biochemistry to Biology to Bedside 04/15/09 Frank Sinicrope, M.D. Mayo Clinic Targeting Bcl-2/Bcl-xL proteins to enhance apoptosis in GI cancers 06/11/09 Sir Nicholas Wright Barts and the London School of Medicine and Dentistry The expansion of mutant stem cells: the beginning of cancer 06/29/09 Alastair J.M. Watson, M.D. University of Liverpool Cell shedding and intestinal barrier function Dept. of Pediatrics Microbes as probes of the host innate mucosal immune and inflammatory response