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Objective: Students will be able to complete a gallery walk activity in order to review for the Genetics Unit of the Biology HSA exam. Drill: 1. Take out the cards your teacher has given you. 2. Match up the vocabulary words with the definition and the picture that best represents each word. 3. Work with your neighbor to discuss answers and then copy the correct answers onto your “Genetics Vocabulary Chart.” Objective: Students will be able to complete a review in order to prepare for the Genetics Unit of the Biology HSA exam. Drill: 1. If you see Natural selection in a test question, what should you do? 2. If you just don’t know the answer, what should you do? 3. Should you always read the questions and all of the answers before making your choice? Vocabulary Genotype Phenotype Homozygous Definition The alleles (letters) that represent a trait. TT or tt The external or physical appearance of a gene. black Both alleles (letters) for gene are same Alleles (letters) for the gene are different Heterozygous Picture Think-Pair-Share: work with your neighbor and complete questions #1-4 on your “Punnett Square Practice Problems” worksheet. Let’s review the answers as a class, then try some more Punnett squares. A “Punnett square” is an easy tool that is used to determine the traits that are passed on from parent to offspring. The first step is to draw a naked Punnett square, which looks like a window pane. Step two: place the alleles for the parents’ traits on the outside of the Punnett square. W W Mom has purple flowers: WW Dad has white flowers: ww w w The squares inside the Punnett square represent the traits of the children the couple would have. Step three: Drop each of the top alleles down in a box below it. Step four: Carry each allele on the side over to each box W Ww W Ww w Important: Always write Ww Ww the dominant allele before the recessive w allele These letters represent the alleles each child received from the parents. The first generation of offspring are called the F1 generation. Since W is dominant it covers up the recessive w. In this case all of the offspring came out Ww, so they will be purple. W W Ww Ww Ww Ww w w Let’s complete #5-7 on your “Punnett Square Practice Problems” worksheet. Parent 1 Genotype: b Bb Brown Fur Parent 1 Phenotype: B Parent 2 Genotype: b Bb Bb bb bb bb Parent 2 Phenotype: White Fur b Genotype ratio: 2 : 2 Phenotype ratio: 2 : 2 Roger has short ears. Genevieve is heterozygous for long ears. Use the steps below to solve the problem. Determine the parent’s genotype and phenotype PARENT #1: PARENT #2: E 1. What are the chances of a baby with the genotype Ee? out of or % e 2. What are the chances of a baby with short ears? out of or % e e Ee ee Ee ee Complete the notes on your “Chromosomes and Sex-Linked Traits” worksheet. If we take all the chromosomes out of one cell and match them up, we find that we have 23 pairs. The first 22 pairs contain the genes that make up our bodies (called autosomes). The 23rd pair are called sex chromosomes because they determine your gender. XX There are two different sex chromosomes, X and Y. If you receive an X and a Y, you are genetically a male. If you receive two X’s then you are genetically a female. XY X chromosomes can carry other traits besides those related to gender. Sex-Linked Traits Hemophilia Male Pattern Baldness Red-Green Colorblindness Duchenne Muscular Dystrophy Today we will look at hemophilia. In order to have offspring you need a female XX and a male XY. These crosses work just like the ones we have done in the past. XX= female baby XY= male baby Ratio = 2:2 or 50% Since sex linked traits involve sex chromosomes, we have to use the letters X and Y. We use superscript letters to represent the trait. Since hemophilia is recessive, we will use a lower case “h”. Now let’s try a cross involving hemophilia to see how it works. Hemophilia occurs when people lack a protein that helps clot blood. X Y h Remember in sex linked traits the allele is only on the X chromosome! Let’s cross a male with hemophilia with a carrier female. XH Xh Genotype Phenotype h H H X X X Normal h h XHXh XHXh X x XhXh Carrier hemophilia XHY Normal XhY hemophilia XHY Xh Y Y Since females have two X’s they need two alleles to get hemophilia. Because males only have one X, they only need one allele to get hemophilia. Antoinette has hemophilia but her husband Bobby is normal. •Draw a Punnett square to predict the genotypes of their children. Xh XH Xh XHxh XHxh XhY XhY •Determine how many children will have hemophilia. Y Interphase Prophase Metaphase Anaphase Telophase & Cytokinesis Two new identical cells Mitosis starts with one parent cell. Each daughter cell also has 4 chromosomes. Parent cell starts with 4 chromosomes Afterwards you have two cells that are identical to the original cell. Growth Healing wounds Asexual Reproduction in Bacteria Cancer Sperm and Egg are called gametes and only have a haploid number or 23 chromosomes. Sperm and egg are made by a process of cell division called Meiosis. 46 chromosomes Woman produces an egg. 23 chromosomes The male produces sperm. 23 chromosomes The sperm fertilizes the egg to make a zygote. Sperm and Egg only have 23 chromosomes and are created by a process called meiosis. The original parent cell has 4 chromosomes. Cell divides once. Daughter cells only have half the number of chromosomes. Cells then divide again 4 Sperm 1 Egg Spermatogenesis Oogenesis Meiosis Mitosis Work with a partner to complete “Comparing and Contrasting Mitosis vs. Meiosis” worksheet. What information can we learn from this pedigree? Male Female 4 Generations Trait Inherited What kind of trait is inherited in this family? How do you know? KEY 1 Normal female 2 Affected female Carrier female 3 4 Normal male Affected male 5 Sex-linked Trait Genotypes: 1. ____ 2. _____ 3. _____ 4. _____ 5. ____ Transcription Translation Scribes were people that used to copy books before the invention of the printing press. Transcription- is when DNA is copied into RNA DNA is our only copy of our genetic blueprint, so we need to keep it nice and safe in the nucleus. DNA has two strands DNA stays in nucleus DNA is larger RNA only has one strand RNA can go anywhere in the cell RNA is smaller RNA has A,U, G, C. DNA has A,T,G,C We can make a copy of a portion of our DNA, called RNA. We can then take RNA to our job site to build our proteins. This RNA is called mRNA because it has a message in it. We learned earlier that DNA has a code that provides instructions on how to build proteins. These instructions are passed on to the mRNA I’m a ribosome, I read the code in mRNA 3 letters at a time. The code in mRNA is read 3 letters at a time. Every 3 letters is called a codon, which codes for an amino acid. This step is called Translation. Codon = three letters = amino acid Third letter GTA CAG We can now translate the mRNA. Each codon equals an amino acid. We will get practice with pedigrees and protein synthesis during our gallery walk next! The artist captured man’s inner struggle with nature. Yeah whatever. It looks like a hot mess to me! You will work in groups of three to complete a gallery walk on Genetics Review problems. You will have a set time at each station. Let’ review answers as a class. We will do the first problem on the “What type of cross am I” worksheet to model how it is done. Your homework is to complete the other two problems. Next class we will study for the evolution part of the HSA