* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Building Materials of Life
Interactome wikipedia , lookup
Polyclonal B cell response wikipedia , lookup
Photosynthesis wikipedia , lookup
Genetic code wikipedia , lookup
Fatty acid synthesis wikipedia , lookup
Western blot wikipedia , lookup
Point mutation wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Nucleic acid analogue wikipedia , lookup
Amino acid synthesis wikipedia , lookup
Signal transduction wikipedia , lookup
Evolution of metal ions in biological systems wikipedia , lookup
Metalloprotein wikipedia , lookup
Protein–protein interaction wikipedia , lookup
Basal metabolic rate wikipedia , lookup
Two-hybrid screening wikipedia , lookup
Nuclear magnetic resonance spectroscopy of proteins wikipedia , lookup
Protein structure prediction wikipedia , lookup
Biosynthesis wikipedia , lookup
Fatty acid metabolism wikipedia , lookup
The Building Materials of Life A survey of organic compounds Compounds may be organic or inorganic. Water is the most abundant inorganic compound in living things. Carbon dioxide is an inorganic compound that supplies carbon for living things. (CO is also inorganic) Organic compounds contain carbon (as well as H & O) • Carbon atoms are special to organic compounds because they can form four covalent bonds. • And they can form chains & ring structures, as well as single, double or triple bonds. Carbon has the ability to form millions of different, large, complex structures. Formulas Organic compounds are often represented by molecular formulas that tell you the numbers and kinds of atoms. Butane Ethanol Aspartame C4H10 C2H5OH C14H18N2O5 Structural formulas can show you the arrangement of the atoms in the molecule. Molecules composed of many molecular units or “building blocks” are called polymers. Polymers often refer to molecules of many smaller molecules. These smaller building blocks called monomers. • Very Large complex polymers are macromolecules. Polymers are produced by condensation reactions in which water molecules are removed between monomers. (Dehydration synthesis) They are broken down into simpler molecules by hydrolysis in which water is added between monomers. Organic Compounds are hydrocarbons… If they consist of only carbon and hydrogen such as methane, propane etc. Gasoline contains hydrocarbons. Carbohydrates Carbohydrates include sugars, starches and cellulose. They are the primary source of energy for living things. • Plants store sugar in starch molecules, while animals can store sugar as glycogen. • Plant cell walls are made of cellulose. Carbohydrates have a ratio of H : O that is 2:1 Example: Sucrose = C12H22O11 I - SUGARS The breakdown of sugars, such as glucose, provides immediate energy to cells. Carbohydrates exist as: • monosaccharides – single sugar • disaccharides – double sugar • polysaccharides - many sugars The building blocks of carbohydrates are simple sugars called monosaccharides. Isomers Notice that the monosaccharides below all have the same chemical formula. Compounds that have the same chemical formula, but different chemical structures are called Isomers. -OSE Notice that all three names have an ose ending. This always means the compound is a sugar. (except cellulose) Bonding Monosaccharides Monosaccharides are the monomers that are chemically bonded to make more complex carbohydrates. Two sugar monomers joined together chemically produce dissacharides II – STARCHES Starches are the storage form of sugars in plants. Plants store carbohydrate products as complex carbohydrates called starch. There may be 500 to 1000 glucose monomers in one starch molecule. There may be attached branching chains of monomers. • Starch is the principle carbohydrate found in plant seeds and tubers; important sources of starch include corn, potato and rice. • Starch exists in the form of granules, each of which consist of several million amylopectin molecules together with an even larger number of amylose molecules. (Since amylopectin is a much larger molecule than amylose, the mass of amylopectin is typically 4 to 5 times that of amylose in starch.) Chitin Chitin is a polysaccharide found in arthropod exoskeletons (crustaceans, arachnids and insects) It is Earth’s second most abundant polysaccharide. It is also found in fungal cell walls. Proteins Proteins are organic compounds made up of mostly carbon, hydrogen, oxygen & nitrogen. Proteins make up many structures, such as cell organelles, muscles, hair and fingernails. Some proteins are called enzymes which help chemical reactions to take place (they’re called catalysts). AMINO ACIDS • Building blocks of proteins are amino acids. (they are the monomers) • Proteins vary by the kinds, amount and arrangement of the amino acids. (There are 20 different types) BASIC AMINO ACID STRUCTURE: • Amino acids can be taken in as food, or formed within living cells. • Amino acids that cannot be produced by the body are called “essential” amino acids and must be provided by diet. Examples of Amino Acids: Formation of Proteins: Amino acids bond to form proteins through condensation reactions. (dehydration synthesis) Protein = Peptide or Polypeptide? Types of Protein Nutrient/Storage Proteins • casein (protein in milk) • albumen (protein in egg whites) • seed protein (for the embryonic seed plant) Structural protein: • collagen protein,which comes in sheet,cables or filaments. (found in body joints,cartilage, tendons, & skin) • keratin (fingernails,hair, feathers & horns) Regulatory protein: • insulin (regulate glucose levels in blood) • growth hormone(regulates body growth) Transport Proteins: • hemoglobin (transports O2 & CO2 in the blood) Protective Proteins: • antibodies in the immune system (destroy pathogens, such as viruses and bacteria cells in the body) • clotting proteins fibrinogen & thrombin (help form blood clots when blood vessels are damaged) Toxins & Poisons • snake venom • bacterial toxins (such as E. coli food poisoning toxin or C. botulinum –botulism) Contractile protein: • actin & myosin in muscle fibers (contracts skeletal muscle for movement) Motility protein: • (tubulin protein in microtubles and cilia & flagella) Catalysts: • enzymes speed the rate of chemical reactions in living organisms. (over 2000 enzymes have been identified) Lipid Functions • long term storage of energy (Fats contain a higher proportion of energy-rich C-H bonds than carbohydrates and therefore contain more chemical energy. Lipids store more than twice the energy per grams as carbohydrates or proteins.) • long term storage of organic carbon • forming a major part of all cell membranes. • They also cushion organs, water proof (not water soluble) and insulate living things. • Oils and fats are known as triglycerides. • Three-fatty acid molecules & one glycerol join. • Three water molecules are formed by a condensation reaction when making a triglyceride. Saturated & Unsaturated Fats • Look at the structural formula of a triglyceride. If there are any double bonds in the fatty acid chains of the triglyceride, it is an unsaturated fat. (More H can be added to the carbons). • If there are more than one double bond in the fatty acids it is polyunsaturated. It this triglyceride saturated, unsaturated or polyunsaturated? Fats, which tend to be solids at room temperature, such as animal fats, are saturated. (They have only single bonds between carbon atoms in their fatty acid chain and have as many H atoms as they can hold.) If only two fatty acid molecules & a phosphate group join to a glycerol, a phospholipid is produced. hydrophilic – water-loving hydrophobic – water-fearing Phospholipids are an important part of cell membranes. The inability of lipids to dissolve in water allows the cell membrane to form a barrier between the inside and outside of the cell. Waxes • A wax consists of a long fatty-acid chain joined to an alcohol chain. • They are highly waterproof, and in plants form a protective coating on outer surfaces. In animals, protective layers are also formed (example: earwax keeps out microbes) Steroids A steroid, unlike most lipids, is composed of 4 interlocking carbon rings (not fatty acids) with various functional groups attached. (example: testosterone) Cholesterol 1) It is needed for cell membranes. 2) It is a major component of a nerve cell’s myelin sheath (outer covering). In a mature brain, the highest amount of cholesterol is found in the myelin. 3) Cholesterol may be produced and broken down by the liver. 4) Too much cholesterol in the blood can form fatty deposits or blockages in blood vessels which may lead to stroke or heart disease. 5) Cholesterol exists in two forms: Low density lipoprotein (LDL) – They tend to form the deposits in the blood vessels. (“Bad cholesterol” ) High density lipoprotein (HDL) – They tend to carry the cholesterol to the liver to be broken down. “Good cholesterol” Some plants store food energy in oils especially in seeds and fruits. There is even a special fats produced by animals for hibernation, dormancy or periods of migration. (Some hibernating animals produce a fat called triacyglycerol). Hibernating animals collect huge amounts of body fat, not only for food reserve, but also as insulation against the cold. Nucleic Acids Nucleic acids such as DNA and RNA store hereditary information for cells. They are made up of building blocks called nucleotides. What is DNA? • Deoxyribonucleic acid • DNA is the molecule of genes. • It is found in the chromosomes. • It holds the instructions to making all the proteins in an organism. What is DNA’s Structure? • DNA is a biological polymer made up of subunits called nucleotides. • DNA Nucleotides are made up of: a) 5-carbon deoxyribose sugar b) phosphate group c) nitrogen-containing base Finally, ATP is the energy molecule for all cell processes. It is produced through the breakdown of glucose during cell respiration. ATP Adenosine triphosphate has a high energy bond that can release energy for cell work.