Download Immunology Male et al., 8 th Ed. 2013.

An-Najah National University
Faculty of Medicine & Health Sciences
Department of Pathology, Immunology and
Microbiology
Immunology7105306
(Compulsory course)
Course Credit Hours: 3
Students Workload: 3
Teacher workload: 3
PREREQUISITES
General Microbiology 7105301
INSTRUCTORS
Alaeddin Abu-Zant, PhD Microbiology and Immunology
Office phone: 2571
Email: [email protected]
TEXT BOOK:
Immunology Male et al., 8th Ed. 2013.
Cellular and Molecular Immunology Abbas et al., 7thEd. 2012.
Basic Immuniology, Abbas et al 2012
REFERENCES
Published scientific papers.
Murphy et al. Janeway's Immunobiology, 8th Ed. 2011
ADDITIONAL MATERIALS OR EQUIPMENT NEEDED FOR THE COURSE
Internet resources
SUPPLEMENTARY MATERIALS
Reviews and articles from the international journals on the web
The references in the library of the University
Commercial Immunology Kit manuals
COURSE DESCRIPTION
This course concentrates on the basic and clinical science of the immune system and its
relationship to other sciences and biological systems of mammals. This course will concentrate on
function-structure relationship of the immune system and its components such as the lymphoid
tissue and cells, the development and function of the immune system, as well as the clinical
science of the immune system and its role in the prevention, causation and diagnosis of human
diseases such as cancer, autoimmune disease and other topics. .
INTENDED LEARNING OUTCOMES
After this course the students should know the basic elements of immunology namely lymphocyte
biology, antigen presentation, humoral, cellular, mucosal immune responses, inflammation,
complement and cytokines. The student should be familiar with different categories of diseases
related to the immune system highlight the hypersensitivity reactions, autoimmunity and
immunodeficiency diseases.
Intended Learning Outcomes of Course (ILOs)
a- Knowledge and Understanding:
a.1. Recognize the normal immune system..
a.2. Describe the mechanisms of innate immunity.
a.3. Recognize antigens, Immunoglobulins and describe antigen - antibody reactions..
a.4. Describe antigen presentation and the major histocompatibility complex..
a.5. Identify inflammation and the inflammatory response.
a.6. Recognize the humoral and cell mediated immune response
a.7. Describe the hypersensitivity reactions and immunodeficiency diseases.
a.8. Explain Immune tolerance and principles of autoimmunity
a.9.Describe the basics of Transplantation and tumor immunity
b- Intellectual Skills.
b.1. Interpret the results of serological tests.
b.2. Recognize the warning signs of immune disorders..
b.3. Recognize the mechanisms and type of graft rejection.
b.4. Recognize the mechanism of autoimmune diseases.
c- Professional and Practical Skills:
c.1. Interpret different immunological reports.
c.2. Distinguish methods of tissue typing.
c.3. Distinguish the methods and tools used in clinical immunology.
c.4. Evaluate results of different immunological tests.
d- General and transferable skills:
d.1. Search Internet data base for diagnostic measures in microbiology.
d.2. Independently learning
d.3. Work in a team
d.4.Respect assisting personal
d.5. Appreciate team work in seminar.
COURSE OUTLINE AND CALENDER
TOPICS
SECTION I:Componenets of the Immune System
Introduction to the Immune System
Cells, Tissues and Organs of the Immune System
Antigens and antibodies
Complement
T cell Receptors and MHC Molecules
HOURS
FIRST HOUR EXAM
Section II: Modes of the Immune Response
Mechanisms of Innate Immunity
Inflamation
Mononuclear Phagocytes in Immune Defense
Antigen presentation
Cell- Mediated Cytotoxicity
T-cell activation
Cell Cooperation in the Antibody Response
Regulation of the Immune Response
Immune Responses in Tissues
25%
SECOND HOUR EXAM
Section III: Defense Against Infectious Agents
Immunity to Viruses
Immunity to bacteria and Fungi
Immunity to Protozoa and Worms
Primary Immunodeficiencies
AIDS, Secondary Immunodeficiencies and Immunosuppression
Vaccination
25%
Section IV: Immune Responses Against Tissues
Immunological Tolerance
Autoimmunity and Autoimmune Disease
Transplantation and Rejection
Immunity to Cancers
Section V: Hypersensitivity
Hypersensitivity Type I ( Immediate Type)
Hypersensitivity Type II
Hypersensitivity Type III
Hypersensitivity Type IV
FINAL EXAM
Total
2
4
4
3
3
1
2
1
2
1
2
2
1
1
1
1
1
2
2
1
1
1
2
2
1
1
40%
45 hours
TEACHING AND LEARNING METHODS:
Tool
Lectures
Case study, small group
discussion sessions and
seminars.
Micro project (e.i. Review
article)
Gateway Science Workshop
Purpose
To explain the theoretical
knowledge for each topic
To apply the knowledge on
a real case, answer the
questions of the students
and evaluate their
knowledge
To teach the students how
to examine the references
and periodicals
ILOs
a.1, a.2, a.3, a.4, a.5,a.6, a.7,
a.8, a.9
b.1, b.2, b.3, b.4, d.3, d.4,
d.5
peer-led program designed to
enhance students' learning
d.1, d.2, d.3, d.4, d.5
TEACHING RESOURCES:
White board
One lecture hall in the department.
Overhead projector
Computer
COURSE POLICIES
Class attendance (Participation)
Student must attend at least 75% of lecture
Moodle participation
Case presentation
GRADING:
First & Second Exams 50%
Final Exam 40%
Presentation 10%
d.1, d.2, a.4, a.5, a.7, a.8,
a.9