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1 CURRICULUM VITAE Name Sex Birthdate Nationality Marital status ROBERT, Benoît Male May 8, 1952 French Married, no children EDUCATION 1973 1974 1978 1985 M.S. in Physiology, University of Poitiers, France M.S. in Biochemistry, University of Toulouse, France First Doctoral Thesis in Molecular Biology, University of Paris Doctoral Thesis in Molecular Biology, University of Paris APPOINTMENTS AND POSITIONS 1975-1978 Fellowship from the Roux Foundation, to study transcription on isolated chromatin and evaluate RNA complexity in cells from an embryonic carcinoma cell line, in Pr. François Gros’ laboratory (Institut Pasteur, Paris). 1978-1987 Research assistant at the Institut Pasteur. Working in Pr. François Gros' laboratory on the structure and organization of contractile protein genes in the mouse genome, and their expression during myogenesis. 1987-1995 Research assistant at the Institut Pasteur (Director of Research from 1992) Working in Dr. Margaret Buckingham's laboratory on the role of the vertebrate Msx homeobox genes in development. 1995-present Director of Research at the Institut Pasteur. Head of the laboratory of Molecular Genetics of Morphogenesis. Working on embryonic induction and vertebrate limb morphogenesis. Honors George Zermatti Foundation Prize in 1989. Administrative Duties Apr. 2000 - present Project manager for the "Transverse Research Programs" of the Institut Pasteur Feb 2004 – Jan. 2008 Associate Principal Investigator in EuroStemCell, a European Consortium for Stem Cell research 1 2 SELECTED PUBLICATIONS Affara, N.A., Robert, B., Jacquet, M., Buckingham, M.E. and Gros, F. (1980) Changes in gene expression during myogenic differentiation : I - Regulation of messenger RNA sequences expressed during myotube formation. J. Mol. Biol. 140, 441-458 Robert, B., Daubas, P., Akimenko, M.A., Cohen, A., Guénet, J.L. and Buckingham, M. (1984) A single locus in the mouse encodes both myosin light chains 1 and 3, a second locus corresponds to a related pseudogene. Cell, 39, 129-140 Robert, B., Barton, P., Minty, A., Daubas, P., Weydert, A., Bonhomme, F., Catalan, J., Chazottes, D., Guénet, J.L. and Buckingham, M. (1985) Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature, 314, 181183 Robert, B., Sassoon, D., Jacq, B., Gehring, W. and Buckingham, M. (1989) Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J. 8, 91-100 Robert, B., Lyons, G., Simandl, B.K., Kuroiwa, A. and Buckingham, M. (1991) The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds. Genes Dev. 5, 2363-2374 Houzelstein, D., Auda-Boucher, G., Tajbakhsh, S., Buckingham, M. E., Fontaine-Perus, J., and Robert, B. (1999). The homeobox gene Msx1 is expressed in the lateral dermomyotome of a subset of somites, and in muscle progenitor cells migrating into the forelimb. Development 126, 2689-2701 Houzelstein, D., Chéraud, Y., Auda-Boucher, G., Fontaine-Pérus, J. and Robert, B. (2000). The expression of the homeobox gene Msx1 reveals two populations of dermal progenitor cells originating from the somites. Development 127, 2155-2164. Bach, A., Lallemand, Y., Nicola, M.-A., Ramos, C., Mathis, L., Maufras, M. and Robert, B. (2003). Msx1 is required for dorsal diencephalon patterning. Development 130, 4025-4036. Lallemand, Y., Nicola, M.-A., Ramos, C., Bach, A., Saint Cloment, C. and Robert, B. (2005). Analysis of Msx ; Msx2 double mutants reveals multiple roles for Msx genes in limb development. Development 132, 3003-3014. Robert, B. and Lallemand, Y. (2006). Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics. Dev Dyn 235, 2337-52. Robert, B. (2007). Bone morphogenetic protein signaling in limb outgrowth and patterning. Develop. Growth Differ. 49, 455–468. Goupille O, Saint Cloment C, Lopes M, Montarras D, Robert, B. (2008) Msx1 and Msx2 are expressed in sub-populations of vascular smooth muscle cells. Dev Dyn 237, 2187-2194. 2