Download Conférence GIRC Tuesday 18. Novembre François Ducray Centre

Conferences
2014
Conférence GIRC
Grenoble Institute for Cancer Research
.
Tuesday 18. Novembre
François Ducray
Centre de Recherche en Neurosciences
(Inserm U 1028, CNRS 5292, Univ Lyon 1)
11h IAB Conference Room
Towards personalized therapy for adult patients
with glioma
Gliomas are adults most frequent primary brain tumors and are associated with a
poor prognosis. Their management is complicated by the fact that their histological
classification lacks reproducibility and prognostic accuracy. Therefore there is a
need for precise diagnostic, prognostic and predictive markers to improve patients
management and treatment. The aim of this presentation will be show how
advances in gliomas molecular characterization as well as mathematical modeling
of glioma growth can improve patients management.
Reyes-Botero et al. POLA Network. Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is
associated with 9p loss, genomic instability, and angiogenic gene expression. Neuro Oncol. 2013 Dec 18.
Laffaire et al. Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis. Neuro Oncol.
2011 Jan;13(1):84-98.
Ducray et al. Diagnostic and prognostic value of alpha internexin expression in a series of 409 gliomas. Eur J
Cancer. 2011 Mar;47(5):802-8.
Ducray et al. Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. Mol
Cancer. 2008 May 20;7:41.
Ribba et al. A tumor growth inhibition model for low-grade glioma treated with chemotherapy or radiotherapy. Clin
Cancer Res. 2012 Sep 15;18(18):5071-80.
*Invited by Chantal Remy
Grenoble Institut Recherche Cancer : Institut Albert Bonniot, Institut de Recherches en
Technologies et Sciences pour le
Vivant, Institut de Biologie Structurale, Grenoble Institut Neurosciences