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Transcript
Hominins evolved three muscles that flex the thumb: -Flexor pollicis longus -Flexor pollicis brevis -1st volar interosseus of Henle (80% of individuals present a pollical palmar interosseous muscle (of the thumb) as suggested by Henle's description in 1858) GENE REGULATION What is the hypothesis? “HACNS1 has undergone several instances of positive selection during human evolution that may have altered its function”. How would you demonstrate this hypothesis (Methods)? Mouse-enhancer assay will show the activity of each sequence by increasing the expression of a b-galactosidase (lacZ) reporter gene coupled to a minimal Hsp68 promoter. Gain of function? substitution rate at the HACNS1 locus proportion of AT → GC substitutions What kind of selection is this?
