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Molecular Immunology Saverio Minucci General informations • PPT slides – home page: http://users.unimi.it/minucci/index.htm – Click on “didattica” : • http://users.unimi.it/minucci/didattica.htm – Anche su ARIEL • Exams: – team presentation of one paper related to the topics discussed during the lessons – 1 written test at the end of the course (open essay: 1 topic of your choice, 1 topic chosen by me) • Official books: none – Abbas/Lichtman (Basic Immunology- or italian translation) – Pier/Lyczak/Wetzler (Immunology, infection and immunity –or italian translation) – Whatever… • X info: – [email protected] – [email protected] Examination dates • • • • • • • - 25 gennaio 12.00-14.00 aula da definire - 08 febbraio 12.00-14.00 aula da definire - 22 febbraio 12.00-14.00 aula da definire - 15 giugno 12.00-14.00 aula da definire - 28 giugno 12.00-14.00 aula da definire - 12 luglio 12.00-14.00 aula da definire - 30 settembre 12.00-14.00 aula da definire A few questions for you… • What’s the difference between innate and adaptive immunity? – What can you say about innate immunity • Describe phagocytosis – How is the phagocyte attracted by its target? • How many types of adaptive immune responses do you know? • Can you give me one example of passive immunity? Let’s define together the cardinal features of adaptive immune responses • • • • Specificity Diversity Memory Non reactivity to self Adaptive immune response • What is a “naïve” T (or B) cell? • How is it that immune cells are able to avoid killing “self” cells? • Activated immune cell becomes either an…….or a ……….cell • What is the difference between a CD4+ and a CD8+ cell? • Which is the cell that is the main producer of antibodies? Lymphocytes • What’s the CD nomenclature? • What is the main difference among B and T lymphocytes? • Which are the main classes of effector T lymphocytes? • What is an APC? What’s the name of the most important class of APCs? Phases of adaptive response • Antigen recognition • Lymphocyte activation • Effector Phase Response to infective agents: an example Topics to be addressed in the course • • • • • • Vaccines Autoimmune diseases Allergy Immunological reactions against tumors Transplantation AIDS and Kaposi sarcoma