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Guidelines for Mechanisms of Development / Gene Expression Patterns papers (1) Is this manuscript appropriate for MOD or for Gene Expression Patterns (GEP)? Does the ms. contain cloning and/or gene expression data? NO YES In addition, are there any experiments that shed light on function or regulation of the gene(s)? YES Possible MOD paper, or GEP if the functional conclusions are not sufficiently definitive or too minor an advance over what is already known or expected. NO Are there experiments (eg transplantation) to elucidate some aspect of the Biology of a developmental process? Is it a database search or screen identifying new genes or reclassifying ESTs or existing genes in a new way? Possible MOD paper, but GEP if the biological conclusions are not sufficiently definitive or too minor an advance over what is already known or expected. YES NO Is there anything novel that will be of developmental interest? NO YES Possible GEP paper NO Does it explore a specific Biological event, or function or regulation of a gene(s)? NOT APPROPRIATE for MOD/GEP YES NO YES Is the gene or process YES directly relevant to Developmental Biology? NOT APPROPRIATE for MOD/GEP NO NOT APPROPRIATE for MOD/GEP YES Possible MOD paper (2) Is this manuscript acceptable for GEP? PART 1: Are data and Figures of high quality? YES Are all the data novel (including reports from other species)? NO Is the study thorough and complete enough “to make it unlikely that a subsequent publication will be needed to describe the expression of this gene(s)”? YES YES Go to PART 2 NO YES NOT APPROPRIATE for MOD/GEP NO Are the differences with previous reports likely to be important? Are the data VERY interesting or important? YES NO NO NOT APPROPRIATE for MOD/GEP NOT APPROPRIATE for MOD/GEP PART 2: Does it contain in situ hybridization and/or antibody staining? Brief functional speculations allowed if informative YES NO YES Is there expression analysis by RT-PCR, Northern, Western or RNAse protection? Need confirmation of expression by in situ or antibody if possible NO Is the expression analysis based on SAGE or another screening method? YES NO NOT APPROPRIATE for MOD/GEP Does it compare different stages, or mutant vs. wild-type in a particular organ/tissue/stage? YES NO NOT APPROPRIATE for MOD/GEP Acceptable, subject to positive reviews