Download Guidelines for Gene Expression Patterns papers

Guidelines for Mechanisms of Development / Gene Expression Patterns papers
(1) Is this manuscript appropriate for MOD or for Gene Expression Patterns (GEP)?
Does the ms. contain
cloning and/or gene
expression data?
NO
YES
In addition, are there any
experiments that shed light on
function or regulation of the
gene(s)?
YES
Possible MOD paper, or GEP if the functional
conclusions are not sufficiently definitive or too
minor an advance over what is already known or
expected.
NO
Are there experiments (eg
transplantation) to elucidate
some aspect of the Biology of a
developmental process?
Is it a database search or screen
identifying new genes or
reclassifying ESTs or existing
genes in a new way?
Possible MOD paper, but GEP if the biological
conclusions are not sufficiently definitive or too
minor an advance over what is already known or
expected.
YES
NO
Is there anything novel that will be of
developmental interest?
NO
YES
Possible GEP paper
NO
Does it explore a specific
Biological event, or function or
regulation of a gene(s)?
NOT APPROPRIATE for MOD/GEP
YES
NO
YES
Is the gene or process
YES directly relevant to
Developmental Biology?
NOT APPROPRIATE for MOD/GEP
NO
NOT APPROPRIATE for MOD/GEP
YES
Possible MOD paper
(2) Is this manuscript acceptable for GEP?
PART 1:
Are data and
Figures of high
quality?
YES
Are all the data novel
(including reports
from other species)?
NO
Is the study thorough and
complete enough “to make
it unlikely that a
subsequent publication will
be needed to describe the
expression of this gene(s)”?
YES
YES
Go to PART 2
NO
YES
NOT APPROPRIATE
for MOD/GEP
NO
Are the differences
with previous reports
likely to be important?
Are the data VERY
interesting or important?
YES
NO
NO
NOT APPROPRIATE for MOD/GEP
NOT APPROPRIATE for MOD/GEP
PART 2:
Does it contain in situ hybridization
and/or antibody staining?
Brief functional speculations
allowed if informative
YES
NO
YES
Is there expression analysis by RT-PCR,
Northern, Western or RNAse protection?
Need confirmation of expression by in
situ or antibody if possible
NO
Is the expression analysis
based on SAGE or another
screening method?
YES
NO
NOT APPROPRIATE for MOD/GEP
Does it compare different stages,
or mutant vs. wild-type in a
particular organ/tissue/stage?
YES
NO
NOT APPROPRIATE for MOD/GEP
Acceptable, subject
to positive reviews