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Principal Investigator/Program Director (Last, First, Middle): Amieva, Manuel, Ricardo BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. Manuel Amieva Assistant Professor of Pediatrics & Microbiology and Immunology eRA COMMONS USER NAME EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION Dartmouth College, Hanover, NJ Stanford University, Stanford, CA DEGREE (if applicable) A.B. M.D./Ph.D. YEAR(s) FIELD OF STUDY 1982-1986 Biology 1988-1997 Med Doc & Cancer Biology Positions and Employment 1997-1999 Resident in Pediatrics, Lucille Packard Children Hospital at Stanford 1999-2002 Pediatric Infectious Disease Fellow, Stanford Medical Center 2000- 2004 Post Doctoral Fellow, Stanford University School of Medicine 2004Assistant Professor of Pediatrics & Microbiology and Immunology, Stanford University Honors 1985-1985 1986 1986 1988-1997 2000 2000-2004 2005-2006 2005-2007 2006 Sigma Xi Undergraduate Research Award. Award given by the Scientific Research Honor Society to the best undergraduate research in the Biological Sciences. Phi Beta Kappa. National Honor Society Biology Degree from Dartmouth College with High Honors. Magna Cum Laude. Medical Scientist Training Program Scholarship. Medical and Research training scholarship funded by the National Institute of Health Awarded Pfizer Postdoctoral Fellowship in Infectious Diseases 2000. Award declined because of coincident PIDS/St. Jude Award Pediatric Infectious Diseases Society / St. Jude Fellowship in Pediatric Infectious Diseases Named Investigator Award- Stanford University Digestive Disease Center MedImmune Career Development Award in Pediatric Infectious Diseases Pediatric Infectious Diseases Society Young Investigator Award Boards American Board of Pediatrics- Board Certified 2003 - 2010 (ABP #077410) Pediatric Infectious Diseases- Board Certified 2005 - 2012 (ABP ID# 616739) Publications 1. Amieva, MR, Reed CG and Pawlik JR. 1987. Ultrastructure and behavior of the larva of Phragmatopoma californica (Polychaeta: Sabellariidae): identification of sensory organs potentially involved in substrate selection. Marine Biology. 95:259-266. 2. Amieva, MR and Reed CG. 1987. Functional morphology of the larval tentacles of Phragmatopoma californica (Polychaeta: Sabellariidae): composite larval and adult organs of multifunctional significance. Marine Biol. 95:243-258. 3. Marin-Padilla, M; Amieva, MR. 1989. Early neurogenesis of the mouse olfactory nerve: Golgi and electron microscopic studies. J Comp Neurol. 288(2):339-352. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Amieva, Manuel, Ricardo 4. Furthmayr H, Lankes W, and Amieva, MR. 1992. Moesin a new cytoskeletal protein and constituent of filopodia its role in cellular functions. Kidney Int. 41:665-670. 5. Amieva MR, Wilgenbus KK, and Furthmayr H. 1994. Radixin is a component of hepatocyte microvilli in situ. Expel Cell Res. 210:140-144. 6. Pestonjamasp K, Amieva MR, Strassel CP, Nauseef WM, Furthmayr H, and Luna EJ. 1995. Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes. Molec Biol Cell. 6:247-259. 7. Amieva MR and Furthmayr H. 1995. Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contacts. Exper Cell Res. 219:180-196. 8. Nakamura F, Amieva MR, and Furthmayr H. 1995. Phosphorylation of threonine 558 in the carboxylterminal actin-binding domain of moesin by thrombin activation of human platelets. J Biol Chem. 270:3137731385. 9. Hugo C, Hugo C, Pichler R Gordon K, Schmidt R, Amieva MR, Couser WG, Furthmayr H, and Johnson R. 1996. The cytoskeletal linking proteins, moesin and radixin, are upregulated by platelet-derived growth factor, but not basic fibroblast growth factor in experimental mesangial proliferative glomerulonephritis. J Clin Invest. 97:2499-2508. 10. Hirota C, Mizuno Y, Amieva MR, Furthmayr H, and Nakamura F. 1996. Phosphorylation of 558T of moesin detected by site-specific antibodies in RAW264.7 macrophages. Biochem. Biophys. Res. Commun. 226:650656. 11. O'Toole EA, Marinkovich MP, Peavey CL, Amieva MR, Furthmayr H, Mustoe TA, and Woodley DT. 1997. Hypoxia increases human keratinocyte motility on connective tissue. J Clin Invest, 100:2881-91. 12. Hugo C, Nangaku M, Shankland SJ, Pichler R, Gordon K, Amieva MR, Couser WG, Furthmayr H, and Johnson RJ. 1998. The plasma membrane-actin linking protein, ezrin, is a glomerular epithelial cell marker in glomerulogenesis, in the adult kidney and in glomerular injury. Kidney Int. 54:1934-44. 13. Amieva MR, Litman P, Huang L, Ichimaru E, and Furthmayr H. 1999. Disruption of dynamic cell surface architecture of NIH3T3 fibroblasts by the N-terminal domains of moesin and ezrin: in vivo imaging with GFP fusion proteins. J Cell Sci. 112:111-25. 14. Litman P, Amieva MR, and Furthmayr H. 2000. Imaging of Dynamic Changes of the Actin Cytoskeleton in Microextensions of Live NIH3T3 Cells with a GFP Fusion of the F-Actin Binding Domain of Moesin. BMC Cell Biol. 1:1. 15. Amieva MR, Salama NR, Tompkins LS, and Falkow S. 2002. Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells. Cellular Microbiol. 4:677-90. 16. Amieva MR, Vogelmann R, Covacci A, Tompkins LS, Nelson WJ, and Falkow, S. 2003. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science. 300:1430-34. 17. Vogelmann R, Amieva MR, Falkow S and Nelson WJ. 2004. Breaking into the epithelial apical-junctional complex – news from pathogen hackers. Curr Opin Cell Biol 16:86-93. 18. Bagnoli F, Buti L, Tompkins L, Covacci A, and Amieva MR. 2005. Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells. Proc. Natl. Acad. Sci USA 102:16339-44. 19. Mueller A, Falkow S, and Amieva MR. 2005. Helicobacter pylori and gastric cancer: What can be learned by studying the response of gastric epithelial cells to the infection? Cancer Epidemiol Biomarkers Prev. 14:1859-64. 20. Amieva MR. 2005. Important bacterial gastrointestinal pathogens in children: A pathogenesis perspective. Pediatr Clin North Am. 52:749-77. 21. Pentecost M, Otto G, Theriot JA, and Amieva, MR. Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion. PLoS Pathogens. 2006. Jan (2)1:e3. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page