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Download Outline --- Programmed Cell Death 1. Apoptosis An overview: the
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Outline --- Programmed Cell Death 1. Apoptosis An overview: the establishment of the concept/field Morphological observations (concept/hypothesis) Medicine/cancer (Bcl-2, the founder of a new class of oncogene) Basic research (proof of the concept by C. elegans genetics) In-depth discussion of certain topics Mitochondria-mediated caspase activation (Bcl-2 family; caspases; Apaf-1; IAPs and Smac; other regulatory mechanisms) (Point of no-return) Crosstalk of the extrinsic pathway with the intrinsic pathway Events after caspase activation Unanswered questions Some new directions Methods for measuring apoptosis Principle underlying each method Pros and cons of each method Cell death and cancer biology Oncogene-induced apoptosis Oncogene addiction Targeting apoptosis directly 2. Non-apoptotic, programmed cell death Conceptually what is the qualification for a programmed but non-apoptotic cell death? Pathways for programmed necrosis, if any Autophagic cell death? 3. Autophagy Mechanism Nutrient sensing kinase mTOR; ATG1/ULK1 kinase complex; ubiquitination-like reactions Cargo-specific autophagy (e.g., mitophagy) Biological functions Role in cell death Cancer/disease relevance Paper to discuss: Glutaminolysis and Transferrin Regulate Ferroptosis. Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Mol Cell. 2015 Jul 16;59(2):298-308. doi: 10.1016/j.molcel.2015.06.011. Epub 2015 Jul 9. PMID: 26166707 Review paper: Regulated necrosis: disease relevance and therapeutic opportunities. Conrad M, Angeli JP, Vandenabeele P, Stockwell BR. Nat Rev Drug Discov. 2016 Jan 18. doi: 10.1038/nrd.2015.6. [Epub ahead of print] PMID: 26775689