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Download Histone Deacetylase 4 Antibody
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Histone Deacetylase 4 Antibody CATALOG NUMBER: 49-282 Immunohistochemistry staining of Histone Deacetylase 4 in lung, respiratory epithelium tissue using Histone Deacetylase 4 Antibody. Specifications SPECIES REACTIVITY: Human, Mouse TESTED APPLICATIONS: IHC, IP, WB APPLICATIONS: Histone Deacetylase 4 antibody can be used in immunohistochemistry starting at 10 ug/mL. USER NOTE: Optimal dilutions for each application to be determined by the researcher. SPECIFICITY: A 140 kD band is observed. IMMUNOGEN: Histone Deacetylase 4 antibody was raised against amino acids 194 - 209 of Histone Deacetylase 4 (Human). HOST SPECIES: Rabbit Properties PURIFICATION: Protein G Column PHYSICAL STATE: Liquid BUFFER: PBS containing 0.05% BSA and 0.05% sodium azide STORAGE CONDITIONS: Histone Deacetylase 4 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. CLONALITY: Polyclonal ISOTYPE: IgG CONJUGATE: Unconjugated Additional Info ALTERNATE NAMES: HDAC4, BDMR, AHO3, Histone deacetylase A, HD4, HA6116, HDAC-A, HDACA, Histone deacetylase 4, HDAC-4, KIAA0288 ACCESSION NO.: P56524 PROTEIN GI NO.: 259016348 OFFICIAL SYMBOL: HDAC4 GENE ID: 9759 Background BACKGROUND: Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins. Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the Nterminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns. These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. FOR RESEARCH USE ONLY December 13, 2016