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Histone Deacetylase Interest in any of the products, request or order them at Bio-Connect. Bio-Connect B.V. Begonialaan 3a 6851 TE Huissen The Netherlands T NL +31 (0)26 326 44 50 F NL +31 (0)26 326 44 51 E [email protected] W www.bio-connect.nl T BE +32 (0)2 503 03 48 F BE +32 (0)2 503 03 27 w w w. s i g n a l c h e m . c o m Active Histone Deacetylases Product Name Cat # Product Name Cat # HDAC1, Active HDAC10, Active HDAC11, Active HDAC2, Active HDAC3, Active HDAC4, Active H83-30G H92-31G H93-30G H84-30G H85-30G H86-31G HDAC5, Active HDAC7, Active HDAC8, Active HDAC9, Active SIRT1, Active SIRT2, Active H87-31G H89-31G H90-30H H91-31G S35-31H S36-30H Product Name SIRT3, Active Cat # S37-38G SIRT5, Active SIRT6, Active SIRT7, Active S39-30H S40-31H S41-30H Sirtuin Proteins Product Name Cat # Product Name Cat # Product Name Cat # SIRT1 Protein SIRT2 Protein S35-31EG S36-30EG SIRT3 Protein SIRT4 Protein S37-30EG S38-30EG SIRT5 Protein SIRT6 Protein S39-30EG S40-30EG email: [email protected] toll free: 1.866.9.KINASE phone: 1.604.232.4600 Histone Deacetylase Sirtuins are class III histone deacetylases that have a NAD+ deacetylase and/or ADPribosyl transferase activity. The 7 members of sirtuins (SIRT1 through SIRT7) posttranslationally modify a number of cellular proteins, affecting cell cycle regulation, cell differentiation, genomic stability, tumorigenesis, oxidative stress response, energy metabolism and other cellular processes. Although there is no direct evidence for the role of sirtuins in extending lifespan in mammals, various mouse models show that small molecules targeting SIRT proteins may treat age-associated diseases including diabetes, cancer and cardiac dysfunction. SignalChem supplies sirtuins that are produced in E. coli cells and in Sf9 insect cells. SIRT proteins produced in E. coli have basal level of activity, whereas those produced in Sf9 cells are highly active (Fig. 1). BULK ORDERS All products supplied by SignalChem are available for purchase in bulk quantities or as a custom preparation. Should you require one of our products to be supplied in a larger pack size or have it formatted to meet your specific research requirements, please contact us by phone 1-866-9 KINASE (54-6273). COMPOUND PROFILING With over 380 targets and expanding everyday, SignalChem offers a diverse panel of active kinases and phosphatases. For a full list of targets, please visit our profiling website or contact us for further information on our profiling service. KINASE-PROFILING.COM [email protected] Fig.1 Comparison of SIRT activity of proteins produced in E.coli and Sf9 cells. The assays were performed using SIRT-Glo technology. References: Finkel, T. et al. (2009) Recent progress in the biology and physiology of sirtuins. Nature Reviews 460:587-591 Lavu, S. et al. (2008) Sitruins - novel therapeutic targets to treat age-associated diseases. Nature Reviews Drug Discovery 7: 841-853 PROMOTIONS Interested in SignalChem’s products? Want to save on your order? SignalChem continues to run a number of promotions and special offers on a wide range of our products. NEWSLETTERS 550-5600 Parkwood Way Richmond, BC V6V 2M2 Canada www.signalchem.com email: [email protected] toll free: 1.866.9.KINASE To get the latest information on SignalChem product offerings, company news and promotions, sign up for one of our many newsletters. phone: 1.604.232.4600