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Transcript
expert reviews http://www-ermm.cbcu.cam.ac.uk Transcriptional activation domain Nuclear localisation signal BRC repeats N C OCCR1 (3059—4075) Binding to P/CAF OCCR2 (6503—6629) Binding to Rad51 Functional domains of the BRCA2 protein Published in Expert Reviews in Molecular Medicine by Cambridge University Press (2001) Figure 1. Functional domains of the BRCA2 protein. The diagram shows the C-terminal nuclear localisation signal and N-terminal transcriptional activation domain; the latter interacts with P/CAF (p300/CBP-associated factor). Binding to the repair protein Rad51 is mediated by BRC repeats. Mutations in the ovarian cancer cluster regions (OCCRs) have been suggested to increase the risk of ovarian, but not breast, cancer; however, this remains controversial. Modified figure reproduced, with permission from Elsevier Science, from Ref. 11 [Welcsh, P.L, Owens, K.N. and King, M.C. (2000) Insights into the functions of BRCA1 and BRCA2. Trends in Genetics 16, 69-74] (fig001mgb). Accession information: (01)00310-6a.pdf (short code: fig001mgb); 14 May 2001 ISSN 1462-3994 ©2001 Cambridge University Press Functional domains of the BRCA2 protein in molecular medicine 1