Download Ovarian cancer infographic_ Amended 4

Age
Early
diagnosis
Environmental
factors
Lifestyle
factors
Family
history
5-year survival
decreases
significantly
with stage of diagnosis2
92%
The risk of
developing ovarian
cancer is increased in
women with specific
inherited genetic
abnormalities. One
of these risks is
associated with
BRCA mutations5
Stage
I
BRCA1 and
BRCA2 belong to
a type of genes
known as tumour
suppressors
Up to 39%
of women
39%
Up to
of women who
inherit a BRCA1
mutation are likely
to develop ovarian
cancer 4
Up to
11-17%
of women
About 1.3%
of women
Up to
11 - 17%
of women who
inherit a BRCA2
mutation are likely to
develop ovarian
cancer 4
with a
in the general
with a
population BRCA2 mutation BRCA1 mut ation
Stage
II/III
OVARIAN CANCER AND
GENETIC TESTING
Genetic mutations can
play a role in the
development and
treatment of cancer
Individuals at risk of
carrying a genetic
mutation can be referred
for genetic testing3
will develop ovarian cancer
by age 70 years4
IMPORTANT: As always, please route any materials included in or developed using this document through your internal AstraZeneca review board as well as local regulatory bodies and nominated signatories as appropriate prior to external distribution.
References:
1
2
3
4
5
6
Cancer Research UK: Risk Factors for Ovarian Cancer. Available at: http://www.cancerresearchuk.org/cancer-info/cancerstats/types/ovary/riskfactors/ Last accessed: May 2016
SEER Cancer Factsheets: Ovary cancer. SEER 18 2003-2009. Available at: http://seer.cancer.gov/statfacts/html/ovary.html Last accessed: May 2016
Gadzicki D, et al. Genetic testing for familial/hereditary breast cancer—comparison of guidelines and recommendations from the UK, France, the Netherlands and Germany. J Community Genet. 2011;2:53-69.
National Cancer Institute. BRCA1 and BRCA2: Cancer Risk and Genetic Testing. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA Last accessed: May 2016
Cancer Genome Atlas Network. Integrated genomic analyses of ovarian carcinoma. Nature. 2011;474:609-15.
World Cancer Research Fund. Ovarian cancer statistics. Available from: http://www.wcrf.org/int/cancer-facts-figures/data-specific-cancers/ovarian-cancer-statistics Last accessed; May 2016
Stage
IV
Date of Expiry: May 2017
of ovarian cancers are diagnosed
at the advanced stage 2
Atlas ID: 976,785.011
28%
Date of Preparation: May 2016
60%
73%
5-YEAR SURVIVAL
Ovarian cancer is the 7 most commonly
diagnosed cancer in women worldwide 6
th
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Several factors may
influence the development
and prognosis of ovarian
cancer, including : 1,2