PRH/Hex - Biochemical Journal
... PRH protein based upon studies of the human and avian proteins. In addition we will review the mechanisms that PRH proteins from all species use to regulate gene expression and cell proliferation. Finally we will review the role of PRH in development, with particular focus on the importance of PRH i ...
... PRH protein based upon studies of the human and avian proteins. In addition we will review the mechanisms that PRH proteins from all species use to regulate gene expression and cell proliferation. Finally we will review the role of PRH in development, with particular focus on the importance of PRH i ...
Pulmonary Surfactant Protein A Activates a
... from the endoplasmic reticulum (ER) (reviewed in Ref. 14). Signals initiated by either G protein-linked receptors or receptors linked directly or indirectly to tyrosine kinases (14) activate phospholipase C (PLC), which hydrolyzes phosphatidylinositol (4,5)bisphosphate to form InsP3 and 1,2-diacylgl ...
... from the endoplasmic reticulum (ER) (reviewed in Ref. 14). Signals initiated by either G protein-linked receptors or receptors linked directly or indirectly to tyrosine kinases (14) activate phospholipase C (PLC), which hydrolyzes phosphatidylinositol (4,5)bisphosphate to form InsP3 and 1,2-diacylgl ...
Myocyte Enhancer Factor 2 Transcription Factors in Heart
... In contrast to the MADS and MEF2 domains, the Cterminal regions of MEF2 proteins are highly-divergent and also highly-variable within a single gene, as a result of regulated RNA splicing. MEF2 primary transcripts are subjected to alternative splicing, skip splicing and cryptic splice site selection, ...
... In contrast to the MADS and MEF2 domains, the Cterminal regions of MEF2 proteins are highly-divergent and also highly-variable within a single gene, as a result of regulated RNA splicing. MEF2 primary transcripts are subjected to alternative splicing, skip splicing and cryptic splice site selection, ...
Identification of core functional region of murine IL-4 using
... sequence analysis (Table 1). The results showed that 23 selected positive clones had relatively high binding affinities for 11B.11 mAb. According to their sequences, all clones were divided into four groups. It was interesting to observe that 17/23 clones showed an identical peptide sequence (RELRYL ...
... sequence analysis (Table 1). The results showed that 23 selected positive clones had relatively high binding affinities for 11B.11 mAb. According to their sequences, all clones were divided into four groups. It was interesting to observe that 17/23 clones showed an identical peptide sequence (RELRYL ...
Bioinformatics analysis of FRG1
... elaborate the role of FRG1p in RNA biogenesis, many FRG1p-interacting proteins were screened and assessed for their role in RNA processing. Co-immunostaining and Coimmunoprecipitation using VSV tagged FRG1 in U20S cells has revealed formation of aggregates with PABPN1 and hyper-phosphorylated RNAP-I ...
... elaborate the role of FRG1p in RNA biogenesis, many FRG1p-interacting proteins were screened and assessed for their role in RNA processing. Co-immunostaining and Coimmunoprecipitation using VSV tagged FRG1 in U20S cells has revealed formation of aggregates with PABPN1 and hyper-phosphorylated RNAP-I ...
Nkx2-5 mutation causes anatomic hypoplasia of the cardiac
... Generation of mutant strains. The Nkx2-5+/neo line was generated by targeted replacement of the WT allele with the Nkx2-5neo construct in AK7 ES cells and injection of positive clones into C57Bl/6 blastocysts, as previously described (12). To make the targeting construct, a neomycin resistance casse ...
... Generation of mutant strains. The Nkx2-5+/neo line was generated by targeted replacement of the WT allele with the Nkx2-5neo construct in AK7 ES cells and injection of positive clones into C57Bl/6 blastocysts, as previously described (12). To make the targeting construct, a neomycin resistance casse ...
Nkx2-5 mutation causes anatomic hypoplasia of the cardiac
... Generation of mutant strains. The Nkx2-5+/neo line was generated by targeted replacement of the WT allele with the Nkx2-5neo construct in AK7 ES cells and injection of positive clones into C57Bl/6 blastocysts, as previously described (12). To make the targeting construct, a neomycin resistance casse ...
... Generation of mutant strains. The Nkx2-5+/neo line was generated by targeted replacement of the WT allele with the Nkx2-5neo construct in AK7 ES cells and injection of positive clones into C57Bl/6 blastocysts, as previously described (12). To make the targeting construct, a neomycin resistance casse ...
Guanylate cyclase in Dictyostelium discoideum with the topology of
... adenylate cyclase (DdCRAC) [2], a Ras guanine nucleotide exchange factor (aimless) [3], Pianissimo [4], and a mitogenactivated protein kinase (DdERK2) [5]. In addition to DdACA, the activation of cAMP and folic acid receptors also leads to the stimulation of guanylate cyclase and phospholipase C act ...
... adenylate cyclase (DdCRAC) [2], a Ras guanine nucleotide exchange factor (aimless) [3], Pianissimo [4], and a mitogenactivated protein kinase (DdERK2) [5]. In addition to DdACA, the activation of cAMP and folic acid receptors also leads to the stimulation of guanylate cyclase and phospholipase C act ...
Regulation of epidermal growth factor receptor signalling by
... and SOCS5 stability. By contrast, the impact of EGFR activation on the RALT half-life has not yet been determined. In summary, these data, although still fragmentary, suggest that transcriptional and post-transcriptional control mechanisms confine the expression of IFIs to a window of a few hours, w ...
... and SOCS5 stability. By contrast, the impact of EGFR activation on the RALT half-life has not yet been determined. In summary, these data, although still fragmentary, suggest that transcriptional and post-transcriptional control mechanisms confine the expression of IFIs to a window of a few hours, w ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.