Secreted protein acidic and rich in cysteine facilitates age
... extracellular matrix (ECM) proteins, such as fibrillar collagen (18, 30, 38). In addition to ECM accumulation, inflammation is a key component of cardiac aging (13, 48). Higher levels of circulating proinflammatory cytokines are observed in elderly people, even in the absence of chronic disease (3, ...
... extracellular matrix (ECM) proteins, such as fibrillar collagen (18, 30, 38). In addition to ECM accumulation, inflammation is a key component of cardiac aging (13, 48). Higher levels of circulating proinflammatory cytokines are observed in elderly people, even in the absence of chronic disease (3, ...
The anorexigenic cytokine ciliary neurotrophic factor stimulates
... translocates to the nucleus, where it activates the transcription of target genes such as that encoding POMC (54). The activation of this signaling pathway by CNTF is negatively modulated by members of the suppressor of cytokine signaling family of proteins (11). Interestingly, we have shown that le ...
... translocates to the nucleus, where it activates the transcription of target genes such as that encoding POMC (54). The activation of this signaling pathway by CNTF is negatively modulated by members of the suppressor of cytokine signaling family of proteins (11). Interestingly, we have shown that le ...
The role of the natriuretic peptides in the cardiovascular system
... membrane and have intracellular kinase and guanylate cyclase catalytic domains, and are thus involved in the cGMP-dependent signaling cascade. The ANP-C receptor lacks an intracellular domain. ANP and BNP both bind the ANP-A receptor with ANP to a higher preference than BNP. A BNP selective receptor ...
... membrane and have intracellular kinase and guanylate cyclase catalytic domains, and are thus involved in the cGMP-dependent signaling cascade. The ANP-C receptor lacks an intracellular domain. ANP and BNP both bind the ANP-A receptor with ANP to a higher preference than BNP. A BNP selective receptor ...
Association of FMRP with Ribosomal Precursor Particles in the
... since in cells from fragile X patients, lacking FMRP, a normal transport of ribosomes from the nucleus to the cytoplasm occurs. On the other hand, the RNA binding properties of FMRP and the in vitro association with ribosomes led to different proposals for a theoretical function for FMRP. One possib ...
... since in cells from fragile X patients, lacking FMRP, a normal transport of ribosomes from the nucleus to the cytoplasm occurs. On the other hand, the RNA binding properties of FMRP and the in vitro association with ribosomes led to different proposals for a theoretical function for FMRP. One possib ...
Analgetika kuat, Schunack
... analgesia. Some research suggests that they may also be related to seizures. The endogenous ligands for the δ receptor are the enkephalins. Until quite recently, there were few pharmacological tools for the study of δ receptors. As a consequence, our understanding of their function is much more li ...
... analgesia. Some research suggests that they may also be related to seizures. The endogenous ligands for the δ receptor are the enkephalins. Until quite recently, there were few pharmacological tools for the study of δ receptors. As a consequence, our understanding of their function is much more li ...
Role of branched-chain amino acid transporters in Staphylococcus
... Staphylococci have the ability to grow in a wide pH range (4.8–9.4), are resistant to drying, and can persist even at extremely high temperatures. Moreover, S. aureus can tolerate high-salt concentrations (7.5–10% NaCl) due to the production of osmoprotectants (142). The ability of S. aureus to ferm ...
... Staphylococci have the ability to grow in a wide pH range (4.8–9.4), are resistant to drying, and can persist even at extremely high temperatures. Moreover, S. aureus can tolerate high-salt concentrations (7.5–10% NaCl) due to the production of osmoprotectants (142). The ability of S. aureus to ferm ...
Role of the leader sequence in tobacco pectin methylesterase
... function both as signal and anchor for insertion into ER membrane. To visualize process of secretion, the PS-GFP construct was used, where PME PS was fused to a foreign GFP gene (Fig. 3A). After agroinjection of PS-GFP (Fig. 3B) GFP was targeted to the CW of epidermal cells. No accumulation of GFP i ...
... function both as signal and anchor for insertion into ER membrane. To visualize process of secretion, the PS-GFP construct was used, where PME PS was fused to a foreign GFP gene (Fig. 3A). After agroinjection of PS-GFP (Fig. 3B) GFP was targeted to the CW of epidermal cells. No accumulation of GFP i ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.