Hemoglobin Receptor in Leishmania Is a Hexokinase Located in the
... growth. Recently, we have shown that Hb endocytosis in Leishmania is mediated through a 46-kDa protein located in the flagellar pocket of Leishmania (8), and signals mediated through the cytoplasmic C-terminal tail of this protein are essential for targeting the protein-bound Hb to the late compartm ...
... growth. Recently, we have shown that Hb endocytosis in Leishmania is mediated through a 46-kDa protein located in the flagellar pocket of Leishmania (8), and signals mediated through the cytoplasmic C-terminal tail of this protein are essential for targeting the protein-bound Hb to the late compartm ...
Hormones and Signal Transduction III
... RAS RAS is a Family of Related Proteins Each is Monomeric and like the α-subunit of G-Proteins RAS Proteins Bind Guanine Nucleotides RAS Swaps GDP for GTP on Activation RAS Slowly Cleaves GTP to GDP ...
... RAS RAS is a Family of Related Proteins Each is Monomeric and like the α-subunit of G-Proteins RAS Proteins Bind Guanine Nucleotides RAS Swaps GDP for GTP on Activation RAS Slowly Cleaves GTP to GDP ...
"Monoclonal Antibodies to Human Cell Surface Antigens". In
... During the last 25 years, large numbers of monoclonal antibodies (MAbs) have been produced that have facilitated the purification and functional characterization of a plethora of leukocyte surface molecules. The antibodies have been even more useful as markers for cell populations, allowing the coun ...
... During the last 25 years, large numbers of monoclonal antibodies (MAbs) have been produced that have facilitated the purification and functional characterization of a plethora of leukocyte surface molecules. The antibodies have been even more useful as markers for cell populations, allowing the coun ...
Phospholamban Is Present in Endothelial Cells and Modulates
... of vasoactive molecules. Phospholamban (PLB) is a 24- to 27-kDa phosphoprotein that modulates activity of the sarco(endo)plasmic reticulum Ca21 ATPase (SERCA). Expression of PLB is reportedly limited to cardiac, slow-twitch skeletal and smooth muscle in which PLB is an important regulator of [Ca21]i ...
... of vasoactive molecules. Phospholamban (PLB) is a 24- to 27-kDa phosphoprotein that modulates activity of the sarco(endo)plasmic reticulum Ca21 ATPase (SERCA). Expression of PLB is reportedly limited to cardiac, slow-twitch skeletal and smooth muscle in which PLB is an important regulator of [Ca21]i ...
Intraflagellar transport protein 172 is essential for primary cilia
... 2005) and platelet-derived growth factor mediated signaling events (Schneider et al., 2005). These findings provide a link between ciliogenesis and known pathways of developmental regulation. To evaluate the role of Ift172 in mouse development, we generated a loss-of-function mutation. The mutant phe ...
... 2005) and platelet-derived growth factor mediated signaling events (Schneider et al., 2005). These findings provide a link between ciliogenesis and known pathways of developmental regulation. To evaluate the role of Ift172 in mouse development, we generated a loss-of-function mutation. The mutant phe ...
Insightful directed evolution of Escherichia coli quorum sensing
... Quorum sensing is a process of cell-cell communication that allows bacteria to enumerate their cell density and modify their behaviors (such as virulence, biofilm formation and antibiotic resistance) in a collective manner. To do this, bacteria ‘talk’ to each other using small molecules called autoi ...
... Quorum sensing is a process of cell-cell communication that allows bacteria to enumerate their cell density and modify their behaviors (such as virulence, biofilm formation and antibiotic resistance) in a collective manner. To do this, bacteria ‘talk’ to each other using small molecules called autoi ...
Expression of biologically active mouse ciliary neutrophic factor
... The CNTF receptor (CNTFR) comprises three subunits: CNTFRa, leukemia inhibitory factor b receptor (LIFRb) and gp130 [40, 41]. CNTFRa is a glycosylphosphatidylinositol (GPI) - anchored protein, which can also be found in a soluble form (sCNTFRa) [42]. The binding of CNTF to membrane bound or soluble ...
... The CNTF receptor (CNTFR) comprises three subunits: CNTFRa, leukemia inhibitory factor b receptor (LIFRb) and gp130 [40, 41]. CNTFRa is a glycosylphosphatidylinositol (GPI) - anchored protein, which can also be found in a soluble form (sCNTFRa) [42]. The binding of CNTF to membrane bound or soluble ...
Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell
... are important in atherosclerosis.7,8 These events are mediated by various cytokines and growth factors, and also depend on the degradation of extracellular matrix by proteinases such as matrix metalloproteinases. The farnesoid X receptor/bile acid receptor (FXR; NR1H4) is a member of the nuclear rec ...
... are important in atherosclerosis.7,8 These events are mediated by various cytokines and growth factors, and also depend on the degradation of extracellular matrix by proteinases such as matrix metalloproteinases. The farnesoid X receptor/bile acid receptor (FXR; NR1H4) is a member of the nuclear rec ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.