Cholesterol and bile acids regulate xenosensor signaling in
... chicken, respectively (4-6,9). In mammals, CAR and PXR exhibit overlapping substrate and DNArecognition specificity and the exact contribution of these two receptors to drug-induction has not been fully elucidated (10-13). In chicken, only one xenobiotic-sensing orphan nuclear receptor has been iden ...
... chicken, respectively (4-6,9). In mammals, CAR and PXR exhibit overlapping substrate and DNArecognition specificity and the exact contribution of these two receptors to drug-induction has not been fully elucidated (10-13). In chicken, only one xenobiotic-sensing orphan nuclear receptor has been iden ...
Allosteric Modulators of Steroid Hormone Receptors: Structural
... unclear. To more fully understand how SHRs function as transcription factors, it is therefore necessary to know how these receptor proteins are activated by hormone and bind to specific DNA sequences in the regulatory regions of target genes to either up- or down-regulate the rate of transcriptional ...
... unclear. To more fully understand how SHRs function as transcription factors, it is therefore necessary to know how these receptor proteins are activated by hormone and bind to specific DNA sequences in the regulatory regions of target genes to either up- or down-regulate the rate of transcriptional ...
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... phosphorylation of FMRP was also shown to increase its association with miRNA precursors [9,10]. Presumably, this interaction works to regulate translation of target mRNAs in an activity-dependent manner. Based on these findings, it has been proposed that the RISC proteins, including Argonaute (Ago) ...
... phosphorylation of FMRP was also shown to increase its association with miRNA precursors [9,10]. Presumably, this interaction works to regulate translation of target mRNAs in an activity-dependent manner. Based on these findings, it has been proposed that the RISC proteins, including Argonaute (Ago) ...
Barley MLA Immune Receptors Directly Interfere
... activator in the presence of the resting or inactive forms of MLA. The active state of MLA releases MYB6 from WRKY1 repressor and stimulates its binding to cognate cis-acting elements to initiate disease resistance signaling. ...
... activator in the presence of the resting or inactive forms of MLA. The active state of MLA releases MYB6 from WRKY1 repressor and stimulates its binding to cognate cis-acting elements to initiate disease resistance signaling. ...
Effects of Glucocorticoid on Microglia Cell Functions
... binding to Type I niineralocorticoid receptor (MR) or Type I1 GC receptor (GR) which are members of a large family of nuclear receptors, and have traditionally been credited with antiinflammatory and in~munosuppressiveactions in the periphery ~nakingthem a pharnlacological tool to treat a variety of ...
... binding to Type I niineralocorticoid receptor (MR) or Type I1 GC receptor (GR) which are members of a large family of nuclear receptors, and have traditionally been credited with antiinflammatory and in~munosuppressiveactions in the periphery ~nakingthem a pharnlacological tool to treat a variety of ...
Hair follicle differentiation: expression, structure and
... consisting of a conserved central region of 310-340 amino acids, capable of adopting an ar-helical coiledcoil conformation, flanked by end domains that are usually large and non-helical (for review see, Steinert and Roop, 1988). The combined protein and gene information indicate that the IF superfam ...
... consisting of a conserved central region of 310-340 amino acids, capable of adopting an ar-helical coiledcoil conformation, flanked by end domains that are usually large and non-helical (for review see, Steinert and Roop, 1988). The combined protein and gene information indicate that the IF superfam ...
Glucocorticoid Receptor-mediated Suppression of the Interleukin 2
... (1-6). I1,2 is the major growth factor for T lymphocytes, which is involved in T cell differentiation, functional activa637 ...
... (1-6). I1,2 is the major growth factor for T lymphocytes, which is involved in T cell differentiation, functional activa637 ...
Targeted expression of SV40 T antigen in the hair follicle of
... cortical cells of the transgenic hairs amino acid analyses were carried out on transgenic hair samples. Table 1 shows the amino acid composition of hair from 2 mice of the no. 40 line, a severe phenotype Fo mouse (Fo-127) and a K2.10 hair-loss transgenic mouse (Powell and Rogers, 1990a), and a norma ...
... cortical cells of the transgenic hairs amino acid analyses were carried out on transgenic hair samples. Table 1 shows the amino acid composition of hair from 2 mice of the no. 40 line, a severe phenotype Fo mouse (Fo-127) and a K2.10 hair-loss transgenic mouse (Powell and Rogers, 1990a), and a norma ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.