Identification of Amino Acid Residues within GABAA Receptor
... has been shown to be functionally silent (Connolly et al., 1996a,b). Receptor expression was analyzed by immunofluorescence with or without membrane permeabilization. Homomeric expression of (FL AG)b2 in A293 cells did not produce surface staining (Fig. 1). The staining pattern in permeabilized cell ...
... has been shown to be functionally silent (Connolly et al., 1996a,b). Receptor expression was analyzed by immunofluorescence with or without membrane permeabilization. Homomeric expression of (FL AG)b2 in A293 cells did not produce surface staining (Fig. 1). The staining pattern in permeabilized cell ...
Hereditary neutropenia - University of Washington
... candidate genes affecting pigmentation and hematopoiesis, based on corresponding phenotypes in humans and mice, confirmed genetic linkage and linkage disequilibrium to AP3B1 [26]. The mutation responsible for gray Collie syndrome is an insertion of an adenine nucleotide residue within a tract of nin ...
... candidate genes affecting pigmentation and hematopoiesis, based on corresponding phenotypes in humans and mice, confirmed genetic linkage and linkage disequilibrium to AP3B1 [26]. The mutation responsible for gray Collie syndrome is an insertion of an adenine nucleotide residue within a tract of nin ...
Receptors as Drug Targets
... • Agonists bind reversibly to the binding site and produce the same induced fit as the natural messenger - receptor is activated • Similar intermolecular bonds formed as with natural messenger • Agonists are often similar in structure to the natural messenger • The agonist must have the correct bind ...
... • Agonists bind reversibly to the binding site and produce the same induced fit as the natural messenger - receptor is activated • Similar intermolecular bonds formed as with natural messenger • Agonists are often similar in structure to the natural messenger • The agonist must have the correct bind ...
Thyroglobulin, the major and obligatory
... folding of the protein, only two phosphate residues were removed readily, which therefore appear to be exposed on the surface of the TG molecule. Enzymatic removal of carbohydrates with endoglycosidase H or with endoglycosidase D was used to test for the presence of phosphate residues on the differe ...
... folding of the protein, only two phosphate residues were removed readily, which therefore appear to be exposed on the surface of the TG molecule. Enzymatic removal of carbohydrates with endoglycosidase H or with endoglycosidase D was used to test for the presence of phosphate residues on the differe ...
Specific localization of nesprin-1-α2, the short isoform of nesprin
... Background: Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is present only in skeletal and cardiac muscle and several pathogenic mutations occur w ...
... Background: Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is present only in skeletal and cardiac muscle and several pathogenic mutations occur w ...
Informatics approaches to understanding TGFb pathway regulation
... preventing R-Smad–Co-Smad complex formation (Miyazono, 2008). Members of the Sno/Corl/Dac family of nuclear corepressors bind to promoter-bound Co-Smads and block their ability to activate transcription. These proteins accomplish this by recruiting transcriptional repressors, such as histone deacety ...
... preventing R-Smad–Co-Smad complex formation (Miyazono, 2008). Members of the Sno/Corl/Dac family of nuclear corepressors bind to promoter-bound Co-Smads and block their ability to activate transcription. These proteins accomplish this by recruiting transcriptional repressors, such as histone deacety ...
Invited Re vie W Epidermal growth factor receptor (EGFR) biology
... The EGFR pathway is among the most extensively studied models in tumor biology, providing one of the first links between an activated oncogene and human tumor formation (Downward et al., 1984). EGFR is a member of the tyrosine kinase receptor superfamily (Fig. 1).These tyrosine kinases are widely be ...
... The EGFR pathway is among the most extensively studied models in tumor biology, providing one of the first links between an activated oncogene and human tumor formation (Downward et al., 1984). EGFR is a member of the tyrosine kinase receptor superfamily (Fig. 1).These tyrosine kinases are widely be ...
The Nhal antiporter of Saccharomyces cerevisiae mediates sodium
... characterization of Na+/H+ antiporters in other yeasts. In Schixosaccharornyces pornbe, the efflux of intracellular Na' is mediated by a Na'/H+ antiporter encoded by the sod2 gene (Jia et al., 1992). This protein shows some similarity to the human and bacterial Na+/H+ antiporters, and extensive homo ...
... characterization of Na+/H+ antiporters in other yeasts. In Schixosaccharornyces pornbe, the efflux of intracellular Na' is mediated by a Na'/H+ antiporter encoded by the sod2 gene (Jia et al., 1992). This protein shows some similarity to the human and bacterial Na+/H+ antiporters, and extensive homo ...
A Conditional System to Specifically Link Disruption of
... The past decade has brought an increased awareness that protein-coding genes can also possess additional nonproteincoding functions. Single transcriptional units with multiple functions suggest interesting mechanisms that influence the cellular state, but their very existence necessitates new geneti ...
... The past decade has brought an increased awareness that protein-coding genes can also possess additional nonproteincoding functions. Single transcriptional units with multiple functions suggest interesting mechanisms that influence the cellular state, but their very existence necessitates new geneti ...
PDF - International Journal of Biological Sciences
... The pine wood nematode, Bursaphelenchus xylophilus, is an invasive plant parasitic nematode and a worldwide quarantine pest. An indigenous species in North America and the causal agent of pine wilt disease, B. xylophilus has devastated pine production in Southeastern Asia including Japan, China, and ...
... The pine wood nematode, Bursaphelenchus xylophilus, is an invasive plant parasitic nematode and a worldwide quarantine pest. An indigenous species in North America and the causal agent of pine wilt disease, B. xylophilus has devastated pine production in Southeastern Asia including Japan, China, and ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.