Fundamentals of Cell Biology
... Figure 11.02: Signaling pathways use linear, convergent, divergent, and branched signaling pathways to generate complex responses to external signals. ...
... Figure 11.02: Signaling pathways use linear, convergent, divergent, and branched signaling pathways to generate complex responses to external signals. ...
Analysis of the stimulation of reporter gene expression by the ¢r3
... type 1 and 3 serotypes (Giantini et aI., 1984; Atwater et al., 1986) has shown that both are 1196 nucleotides in length with a single long open reading frame encoding the ~r3 protein of 365 amino acids. Despite the observed differences in the phenotypes of these genes with respect to host cell RNA a ...
... type 1 and 3 serotypes (Giantini et aI., 1984; Atwater et al., 1986) has shown that both are 1196 nucleotides in length with a single long open reading frame encoding the ~r3 protein of 365 amino acids. Despite the observed differences in the phenotypes of these genes with respect to host cell RNA a ...
Ethanol Induces Heterotopias in Organotypic
... Reelin binds to at least two receptors, very low density lipoprotein receptor (VLDLR) and apolipoprotein-E receptor type 2 (ApoER2) (Hiesberger et al., 1999; Trommsdorff et al., 1999). Reelin-receptor binding causes the phosphorylation of an adaptor protein Disabled 1 (Dab1). Dab1 is attached to the ...
... Reelin binds to at least two receptors, very low density lipoprotein receptor (VLDLR) and apolipoprotein-E receptor type 2 (ApoER2) (Hiesberger et al., 1999; Trommsdorff et al., 1999). Reelin-receptor binding causes the phosphorylation of an adaptor protein Disabled 1 (Dab1). Dab1 is attached to the ...
The Amino Terminus of Gαz is Required for Receptor Recognition
... cyclase (AC) in a similar fashion (Wong et al., 1992; Kozasa and Gilman, 1995). The sequence identities are even higher when only their C-terminal halves are compared, where the putative receptor- and effector-interacting domains were located. However, subtle differences are found between the amino ...
... cyclase (AC) in a similar fashion (Wong et al., 1992; Kozasa and Gilman, 1995). The sequence identities are even higher when only their C-terminal halves are compared, where the putative receptor- and effector-interacting domains were located. However, subtle differences are found between the amino ...
Molecular Components of the Signal Sequence that Function in the
... One of the characteristic phenotypes exhibited by strains carrying the 42-1 fusion is related to the inability of the cell to export the LamB-LacZ hybrid protein efficiently. When cells containing this gene fusion are grown in the presence of maltose to induce high-level synthesis of the hybrid prot ...
... One of the characteristic phenotypes exhibited by strains carrying the 42-1 fusion is related to the inability of the cell to export the LamB-LacZ hybrid protein efficiently. When cells containing this gene fusion are grown in the presence of maltose to induce high-level synthesis of the hybrid prot ...
Receptor Fragments: Intracellular Signaling and
... novel mechanism for regulation of cell surface receptor accumulation. Once again, the fate of the remaining portion of the receptor is unknown. Recent studies suggest that the extracellular domain of the β2-adrenergic receptor is also cleaved [8]. Spontaneously hypertensive rats (SHR) appear to have ...
... novel mechanism for regulation of cell surface receptor accumulation. Once again, the fate of the remaining portion of the receptor is unknown. Recent studies suggest that the extracellular domain of the β2-adrenergic receptor is also cleaved [8]. Spontaneously hypertensive rats (SHR) appear to have ...
The Carboxyl Terminus of the Prolactin
... interaction with GRIP is not protein kinase C-regulated but may be regulated by other unidentified kinase because okadaic acid dramatically reduced GRIP interaction. By in situ hybridization, we show that the PrRP receptor is expressed in neurons that also express these PDZ domain proteins. We thus ...
... interaction with GRIP is not protein kinase C-regulated but may be regulated by other unidentified kinase because okadaic acid dramatically reduced GRIP interaction. By in situ hybridization, we show that the PrRP receptor is expressed in neurons that also express these PDZ domain proteins. We thus ...
Synapse
... Norepinephrine acts as a neurotransmitter and a hormone. In the peripheral nervous system, it is part of the flight-or-flight response. In the brain, it acts as a neurotransmitter regulating normal brain processes. Norepinephrine is usually excitatory, but is inhibitory in a few brain areas. ...
... Norepinephrine acts as a neurotransmitter and a hormone. In the peripheral nervous system, it is part of the flight-or-flight response. In the brain, it acts as a neurotransmitter regulating normal brain processes. Norepinephrine is usually excitatory, but is inhibitory in a few brain areas. ...
Chapter 45 Hormones and the Endocrine System
... Insulin also inhibits the glycogen break down in the liver and inhibits the conversion of amino acids and glycerol from fats to sugar. In general, insulin takes glucose out of the blood, causing it to be used in energy production or converted to other forms (glycogen and fats), and promotes protein ...
... Insulin also inhibits the glycogen break down in the liver and inhibits the conversion of amino acids and glycerol from fats to sugar. In general, insulin takes glucose out of the blood, causing it to be used in energy production or converted to other forms (glycogen and fats), and promotes protein ...
44. a. Classify cholinergic receptors and subtypes, agonists and
... Cholinergic Receptors (Cholinoceptors) -The postsynaptic cholinergic receptors on the surface of the effector organs are divided into two classes 1- Muscarinic 2- Nicotinic -Binding to a receptor leads to a biologic response within the cell . -The two families of cholinoceptors, can be distinguished ...
... Cholinergic Receptors (Cholinoceptors) -The postsynaptic cholinergic receptors on the surface of the effector organs are divided into two classes 1- Muscarinic 2- Nicotinic -Binding to a receptor leads to a biologic response within the cell . -The two families of cholinoceptors, can be distinguished ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.