![6-ch05-proteins -Lec 6 [Compatibility Mode]](http://s1.studyres.com/store/data/017899684_1-cb6edbdb206d05d5bf8e42c578a5302b-300x300.png)
Identification of the Sites of Asparagine
... We also demonstrated that all six potential N-linked glycosylation sites on TSHR ectodomain are actually glycosylated in CHO-Lec8 cells. However, it is uncertain that TSHR endogenously expressed in thyroid cells also contains six N-linked carbohydrates. It has been reported that the number of the ac ...
... We also demonstrated that all six potential N-linked glycosylation sites on TSHR ectodomain are actually glycosylated in CHO-Lec8 cells. However, it is uncertain that TSHR endogenously expressed in thyroid cells also contains six N-linked carbohydrates. It has been reported that the number of the ac ...
Protein traffic in polarized epithelial cells: the polymeric
... In these fibroblasts, when the plg-R reaches the cell sur face it is not immediately cleaved to SC. This results in a pool of uncleaved receptor on the surface where it is capable of internalizing bound ligand. About 35% of the bound ligand can be internalized. This endocytosed ligand is rapidly re ...
... In these fibroblasts, when the plg-R reaches the cell sur face it is not immediately cleaved to SC. This results in a pool of uncleaved receptor on the surface where it is capable of internalizing bound ligand. About 35% of the bound ligand can be internalized. This endocytosed ligand is rapidly re ...
Issues in predicting protein function from sequence
... accurate for genes found in completely sequenced genomes. Even for such genomes, past lineage-speci®c deletions of paralogous genes can result in paralogues falsely being predicted as orthologues. Additional complexities in assignment arise from complete genome, or largescale gene, duplications that ...
... accurate for genes found in completely sequenced genomes. Even for such genomes, past lineage-speci®c deletions of paralogous genes can result in paralogues falsely being predicted as orthologues. Additional complexities in assignment arise from complete genome, or largescale gene, duplications that ...
How Do Plant Mitochondria Avoid Importing Chloroplast Proteins
... known sizes of subunits in the yeast complex. In particular, no homologs of Tom37 or Tom22 were apparent and there was an additional protein of around 9 kD. The absence of Tom37 from the plant complex was not so surprising, since this subunit is also missing from the N. crassa complex, and the Tom37 ...
... known sizes of subunits in the yeast complex. In particular, no homologs of Tom37 or Tom22 were apparent and there was an additional protein of around 9 kD. The absence of Tom37 from the plant complex was not so surprising, since this subunit is also missing from the N. crassa complex, and the Tom37 ...
receptors. properties of ROR alpha, a novel
... Cloning of RORal, RORa2, and RORa3 ROR was isolated as part of a screen to identify RAR- and RXR-related genes that might play a direct or even an indirect role in vitamin A physiology. The DNA-binding domain of the human RARa was used as a probe to screen recombinant DNA libraries to search for unr ...
... Cloning of RORal, RORa2, and RORa3 ROR was isolated as part of a screen to identify RAR- and RXR-related genes that might play a direct or even an indirect role in vitamin A physiology. The DNA-binding domain of the human RARa was used as a probe to screen recombinant DNA libraries to search for unr ...
Pegvisomant, a Growth Hormone-Specific Antagonist, Undergoes
... tensity of fluorescence between ligands, because the affinity of the detection antibody differed between the ligands. However, in the calculation of percent internalization, we are comparing the same ligand at the cell surface with that internalized under identical experimental conditions. Therefore ...
... tensity of fluorescence between ligands, because the affinity of the detection antibody differed between the ligands. However, in the calculation of percent internalization, we are comparing the same ligand at the cell surface with that internalized under identical experimental conditions. Therefore ...
Gene repression by nuclear hormone receptors
... roughly divided into receptors that bind to steroids, receptors that bind to non-steroids and orphan receptors for which no ligand is yet known. Interestingly, hormone-bound NHRs can have both activation and repression functions. When bound to their response element they activate target genes; howev ...
... roughly divided into receptors that bind to steroids, receptors that bind to non-steroids and orphan receptors for which no ligand is yet known. Interestingly, hormone-bound NHRs can have both activation and repression functions. When bound to their response element they activate target genes; howev ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.