Cytokine receptors and signal transduction
... itself and the receptor. A Signal Transducer and Activator of Transkription (STAT) protein (S) binds to tyrosine-phosphorylated receptor-kinase complex. After being phosphorylated by JAK, the STATs form active dimers that translocate into the nucleus to regulate transkription. ...
... itself and the receptor. A Signal Transducer and Activator of Transkription (STAT) protein (S) binds to tyrosine-phosphorylated receptor-kinase complex. After being phosphorylated by JAK, the STATs form active dimers that translocate into the nucleus to regulate transkription. ...
Bovine prolactin soluble receptor ECD ECD-11
... Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine re ...
... Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine re ...
Transcriptional control of midbrain dopaminergic neuronal
... regimens for brain diseases caused by dysfunction of the neuronal group. To accomplish subneuronspecific gene modification, our efforts have been centered on the development of novel promoter systems driving gene expression exclusively in a specific neuronal cell type. By devising two unique methods ...
... regimens for brain diseases caused by dysfunction of the neuronal group. To accomplish subneuronspecific gene modification, our efforts have been centered on the development of novel promoter systems driving gene expression exclusively in a specific neuronal cell type. By devising two unique methods ...
Malayer research
... The specialized functions of differentiated cell types in complex, multi-cellular organisms are the result of specific expression of subsets of genes present in the genome. The processes that establish and maintain these patterns of expression begin in the earliest developmental stages. We are inter ...
... The specialized functions of differentiated cell types in complex, multi-cellular organisms are the result of specific expression of subsets of genes present in the genome. The processes that establish and maintain these patterns of expression begin in the earliest developmental stages. We are inter ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.