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Link to BioQUEST Lesson Acetylcholine Receptor Binding Toxins Naja naja: α-cobra toxin source Hypothesis: Similar functioning proteins that bind the ACh receptors will have similar amino acid sequences. Bungarus multicinctus: κ-bungarotoxin toxin source Results: *Overlay: α-cobra toxin a (Y), κ-bungarotoxin (B), Cobratoxin (G), Erabutoxin (O) ACh Receptor *Phylogenetic Tree: Conclusion: Four (4) toxins that affect ACh receptors were found to be closely related evolutionarily resulting in proteins that have structural areas of similarity in their amino acid sequences. TLECHNQQSSQTPTTTGCSGGETNCYKKRWRD----HRGYRTERGCG--CPSVKN-GIEINCCTTDRCNN-*Associated Amino Acid Residue Sequences: -RICFNHQSSQPQTTKTCSPGESSCYNKQWSD----FRGTIIERGCG--CPTVKP-GIKLSCCESEVCNN-α-bungarotoxin TIVCHTTATS-PISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKP-YEEVTCCSTDKCNPHP κ-bungarotoxin TRTCLISPSS---TPQTCPNGQDICFLKAQCDKFCSIRGPVIEQGCVATCPQFRSNYRSLLCCTTDNCNH-Cobratoxin Erabutoxin TLECHNQQSSQTPTTTGCSGGETNCYKKRWRD----HRGYRTERGCG--CPSVKN-GIEINCCTTDRCNN--RICFNHQSSQPQTTKTCSPGESSCYNKQWSD----FRGTIIERGCG--CPTVKP-GIKLSCCESEVCNN-TIVCHTTATS-PISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKP-YEEVTCCSTDKCNPHP
