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* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Known Human Pathogen/Biological Toxin 1. List the infectious agent(s), toxin(s) and/or other biohazardous agent(s) that will be used in this project. Include strain/cultivar/serotype if known. 2. Origin of the agent (Ex: clinical isolate from CVM Clinic, ATCC, colleague from the University of Hawaii etc.) 3. Risk group (1 through 4) designation: 4. Biosafety Level (BSL) assignment (1-4): 5. What is the host range of the agent(s)? 6. What is the pathogenicity (ability to cause disease) and virulence (degree of pathogenicity) of organism(s) to be used in this study? 7. Is it communicable? (Can it spread from human to human, animal to human?) 8. What is the reservoir for the agent? (soil, another mammal, arthropod, humans etc.) 9. What is the natural route of transmission? (inhalation, biting insect, direct contact, ingestion etc.) 10. What is the normal portal of entry into humans (Examples: lungs, mouth, non-intact skin etc.) 11. What would be the most likely route in a laboratory setting? (Examples: inadvertent aerosol production; parenteral inoculation; mucous membrane exposure etc.) 12. Is the agent endemic or exotic? Page 1 of 2 13. What is the potential outcome of exposure to a lab worker? (none to subclincal infection to clinical disease to death) 14. Is there local availability of effective preventative measures such as antibiotics, antivirals, vaccination etc.? If yes, what are they? If no, what will be done in the event of an exposure? 15. What is the infectious dose, if known, for humans? 16. How stable is the agent in the environment? 17. What is the total volume of the agent at any one time? 18. What is the concentration of the agent? Include stock and working dilutions. 19. Is there any information available on the agent in animal model studies? 20. Are there any reports of laboratory acquired infections (LAI) with this agent? 21. What is the LD50 of the toxin in humans and /or animals, if applicable? 22. What is the mechanism of action of the toxin, if applicable? Page 2 of 2