... expressing particular genes only when required. Gene expression in bacteria is regulated primarily at the level of transcription initiation by modulating promoter recognition of the RNA polymerase (RNAP) holoenzyme. The bacterial RNAP holoenzyme is composed of a five-subunit core enzyme (RNAPc; subu ...
109 y+-TYPE CATIONIC AMINO ACID TRANSPORT
... cDNA clones from two closely related lymphoma cell lines (MacLeod et al. 1984, 1985) and resulted in the isolation of several novel cDNAs. One of the novel genes was named Tea, because it is induced early in the response of normal T cells to mitogens (MacLeod et al. 1990a). The cDNA sequence reveale ...
... cDNA clones from two closely related lymphoma cell lines (MacLeod et al. 1984, 1985) and resulted in the isolation of several novel cDNAs. One of the novel genes was named Tea, because it is induced early in the response of normal T cells to mitogens (MacLeod et al. 1990a). The cDNA sequence reveale ...
The Physiology of the Distal Tubules and Collecting Ducts
... The major role of aldosterone is to increase extracellular volume in response to volume depletion signaled by the renin-angiotensin system. Aldosterone plays an role in K+ homeostasis: – High extracellular K+ stimulates aldosterone secretion – K+ secretion is linked to aldosterone-regulated Na+ reab ...
... The major role of aldosterone is to increase extracellular volume in response to volume depletion signaled by the renin-angiotensin system. Aldosterone plays an role in K+ homeostasis: – High extracellular K+ stimulates aldosterone secretion – K+ secretion is linked to aldosterone-regulated Na+ reab ...
invited review - AJP
... form intracellular vesicles that fuse with endosomes (79, 97). Nonspecific endocytosis is a constitutive process by which substances are taken up in proportion to their concentration in the adjacent extracellular fluid (79, 97). In contrast, receptor-mediated endocytosis involves specific binding of ...
... form intracellular vesicles that fuse with endosomes (79, 97). Nonspecific endocytosis is a constitutive process by which substances are taken up in proportion to their concentration in the adjacent extracellular fluid (79, 97). In contrast, receptor-mediated endocytosis involves specific binding of ...
Like-acetylglucosaminyltransferase (LARGE)
... mutation in the Large gene, is defective in α-dystroglycan glycosylation and develops both muscular dystrophy and brain abnormalities (4, 14). Skeletal muscle and brain from Largemyd mice and patients harboring mutations in the LARGE gene have reduced α-dystroglycan laminin-binding activity (4, 6, 1 ...
... mutation in the Large gene, is defective in α-dystroglycan glycosylation and develops both muscular dystrophy and brain abnormalities (4, 14). Skeletal muscle and brain from Largemyd mice and patients harboring mutations in the LARGE gene have reduced α-dystroglycan laminin-binding activity (4, 6, 1 ...
Engineered tRNA suppression of a CFTR nonsense mutation
... resultingin wild type protein sequence. Once identified, the subsequent expression of this tRNA within a target cell will serve to ‘suppress’ the disease PTC upon being acylated (aka ‘charged’) by its cognate synthetase that is endogenously expressed in the cell. The key to the overall success of th ...
... resultingin wild type protein sequence. Once identified, the subsequent expression of this tRNA within a target cell will serve to ‘suppress’ the disease PTC upon being acylated (aka ‘charged’) by its cognate synthetase that is endogenously expressed in the cell. The key to the overall success of th ...
Short Forms of Membrane Receptors: Generation and Role in
... of prolactin receptor are expressed in humans. The cytoplasmic domain of the first short form, S1a, contains amino acid residues encoded by a part of exon 10 and also a unique 39-membered amino acid sequence encoded by exon 11. Generation of intracellular domain of S1b form does not involve exon 10 ...
... of prolactin receptor are expressed in humans. The cytoplasmic domain of the first short form, S1a, contains amino acid residues encoded by a part of exon 10 and also a unique 39-membered amino acid sequence encoded by exon 11. Generation of intracellular domain of S1b form does not involve exon 10 ...
Plant hormone perception and action: a role for G-protein
... Phil. Trans. R. Soc. Lond. B (1998) 353, 1425^1430 ...
... Phil. Trans. R. Soc. Lond. B (1998) 353, 1425^1430 ...
Interleukin-4 Deficiency Decreases Atherosclerotic Lesion
... Polymerase chain reaction (PCR) analysis of hematopoietic cells was performed to determine the genotype of recipient mice. DNA was isolated from bone marrow by using a Dneasy Kit (Qiagen). Primers specific for either IL-4 (5⬘-GCACAGAGCTATTGATGGGTC-3⬘, 5⬘-GCTGTGAG GACGTTTGGC-3⬘, and 5⬘-TCAGGACATAGCGT ...
... Polymerase chain reaction (PCR) analysis of hematopoietic cells was performed to determine the genotype of recipient mice. DNA was isolated from bone marrow by using a Dneasy Kit (Qiagen). Primers specific for either IL-4 (5⬘-GCACAGAGCTATTGATGGGTC-3⬘, 5⬘-GCTGTGAG GACGTTTGGC-3⬘, and 5⬘-TCAGGACATAGCGT ...
hospital/institute/center - Advances in Inflammatory Bowel Diseases
... 1. Metabolic pathways of the mucosal microbiota in CD do not vary as much as UC with inflammation state, indicating a more systemic perturbation of host-bacteria interactions in CD compared to more localized dysfunction in UC. 2. The alterations in metabolic pathways correlate specifically with freq ...
... 1. Metabolic pathways of the mucosal microbiota in CD do not vary as much as UC with inflammation state, indicating a more systemic perturbation of host-bacteria interactions in CD compared to more localized dysfunction in UC. 2. The alterations in metabolic pathways correlate specifically with freq ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.