WWOX, a Novel WW Domain-containing Protein
... Interestingly, the NH2 terminus of the putative WWOX protein showed homology to ubiquitin ligases such as NEDD4, YES-associated protein YAP65, and other WW domain-containing proteins (data not shown). Further amino acid sequence analysis using the PROSITE database identified two regions within the p ...
... Interestingly, the NH2 terminus of the putative WWOX protein showed homology to ubiquitin ligases such as NEDD4, YES-associated protein YAP65, and other WW domain-containing proteins (data not shown). Further amino acid sequence analysis using the PROSITE database identified two regions within the p ...
Inhibition of signal transduction pathways involved in inflammation G. Haegeman
... pathway and the concomitant production of inflammatory cytokines. In order to understand the inflammatory process at the "molecular" level and thus devise more specific molecular targets for the development of novel anti-inflammatory drugs, the author9s group has studied signal transduction pathways ...
... pathway and the concomitant production of inflammatory cytokines. In order to understand the inflammatory process at the "molecular" level and thus devise more specific molecular targets for the development of novel anti-inflammatory drugs, the author9s group has studied signal transduction pathways ...
as a PDF
... AF-1 domain (28), has been identified as a major site of ligand-stimulated phosphorylation (18, 26) and has also been shown to be phosphorylated by mitogenactivated protein kinase in response to EGF stimulation of cells (19, 20). Conversion of this residue to a nonphosphorylatable alanine (HE457) ab ...
... AF-1 domain (28), has been identified as a major site of ligand-stimulated phosphorylation (18, 26) and has also been shown to be phosphorylated by mitogenactivated protein kinase in response to EGF stimulation of cells (19, 20). Conversion of this residue to a nonphosphorylatable alanine (HE457) ab ...
11_Lecture_picture version
... 1. Signaling recognition: chemical messenger (ligand) binds to receptor protein. – Chemical messenger can be a peptide, small inorganic molecule, or lipid hormone ...
... 1. Signaling recognition: chemical messenger (ligand) binds to receptor protein. – Chemical messenger can be a peptide, small inorganic molecule, or lipid hormone ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.