Pathogenic LRRK2 Mutations Do Not Alter Gene
... carriers and a cell line system over-expressing LRRK2 wild type and mutant transgenes for alterations in gene expression due to the presence of mutant LRRK2. Overall, our data show that any differences in gene expression are lower than the relatively modest cutoffs (1.5 fold, p,0.05 after correction ...
... carriers and a cell line system over-expressing LRRK2 wild type and mutant transgenes for alterations in gene expression due to the presence of mutant LRRK2. Overall, our data show that any differences in gene expression are lower than the relatively modest cutoffs (1.5 fold, p,0.05 after correction ...
Project proposal paper - igem
... response to light (1). Instead, E. coli uses chemotaxis to direct its movement towards attractants and away from repellents (1-7). E. coli have about six randomly placed flagella about their surface that are continuously rotating. Clockwise rotation causes the flagella to bundle together and coopera ...
... response to light (1). Instead, E. coli uses chemotaxis to direct its movement towards attractants and away from repellents (1-7). E. coli have about six randomly placed flagella about their surface that are continuously rotating. Clockwise rotation causes the flagella to bundle together and coopera ...
Characterization of a novel phosphatidylinositol 3
... as novel zinc fingers that are present in a variety of proteins implicated in vesicular trafficking. These 70 residue domains are highly conserved between species and are named after the first four proteins (Fab1p, YOTB, Vac1p and EEA1) shown to contain them [1]. Although first identified in protein ...
... as novel zinc fingers that are present in a variety of proteins implicated in vesicular trafficking. These 70 residue domains are highly conserved between species and are named after the first four proteins (Fab1p, YOTB, Vac1p and EEA1) shown to contain them [1]. Although first identified in protein ...
Lung cysts in Birt-Hogg-Dubé syndrome: Histopathological
... Expression of FLCN in the lung To clarify whether FLCN, the protein encoded by BHD gene, is detectable in the lung, immunostaining was performed. According to a previous study using in situ hybridization, BHD mRNA was shown to be expressed in alveolar macrophages, stromal fibroblasts and pneumocytes ...
... Expression of FLCN in the lung To clarify whether FLCN, the protein encoded by BHD gene, is detectable in the lung, immunostaining was performed. According to a previous study using in situ hybridization, BHD mRNA was shown to be expressed in alveolar macrophages, stromal fibroblasts and pneumocytes ...
DMD # 35568 - Drug Metabolism and Disposition
... mice, suggesting that LXR may repress PB-mediated CAR activation and Cyp2b10 induction in vivo (Gnerre et al., 2005). Our lab recently showed that LXRα and CAR are mutually suppressive and functionally related in vivo. Specifically, loss of CAR increased the expression of lipogenic LXR target genes, ...
... mice, suggesting that LXR may repress PB-mediated CAR activation and Cyp2b10 induction in vivo (Gnerre et al., 2005). Our lab recently showed that LXRα and CAR are mutually suppressive and functionally related in vivo. Specifically, loss of CAR increased the expression of lipogenic LXR target genes, ...
Isolation and Characterization of Piscine Osteonectin and
... spawning migration from calcium-rich seawater to freshwater(7,8) and as a result of treatment of rainbow trout, Oncorhynchus mykiss, with estrogen.(9) Moreover, osteoclast-specific TRACP activity is increased in 17-estradiol (E2)-treated goldfish, Carassius auratus, scales in vitro(10) and in vivo, ...
... spawning migration from calcium-rich seawater to freshwater(7,8) and as a result of treatment of rainbow trout, Oncorhynchus mykiss, with estrogen.(9) Moreover, osteoclast-specific TRACP activity is increased in 17-estradiol (E2)-treated goldfish, Carassius auratus, scales in vitro(10) and in vivo, ...
Alterations in Calcium Antagonist Receptors and Sodium
... weight, did not show significant differences between the control and CM hamsters until 180 days of age. Although the ratio of heart weight to body weight is more often used as an index of gross hypertrophy, the ratio of heart weight to brain weight may be preferable, because the CM hamsters have slo ...
... weight, did not show significant differences between the control and CM hamsters until 180 days of age. Although the ratio of heart weight to body weight is more often used as an index of gross hypertrophy, the ratio of heart weight to brain weight may be preferable, because the CM hamsters have slo ...
Role and function of macrophages in the metabolic syndrome
... and the cross-talk between tissues in the progression of metabolic diseases, it is often difficult to tease apart the precise contribution of individual macrophage populations to the onset and development of systemic metabolic dysfunction. Nonetheless, it is clear that the interaction between macrop ...
... and the cross-talk between tissues in the progression of metabolic diseases, it is often difficult to tease apart the precise contribution of individual macrophage populations to the onset and development of systemic metabolic dysfunction. Nonetheless, it is clear that the interaction between macrop ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.