NMDA Receptor Function and Physiological Modulation
... temporal pattern and amplitude of the calcium transient. Synaptic calcium influx also leads to activation of cyclic adenosine monophosphate response element binding protein (CREB), a transcription factor, resulting in activation of gene expression. One of the genes upregulated in response to activat ...
... temporal pattern and amplitude of the calcium transient. Synaptic calcium influx also leads to activation of cyclic adenosine monophosphate response element binding protein (CREB), a transcription factor, resulting in activation of gene expression. One of the genes upregulated in response to activat ...
Amino acid transporters: roles in amino acid sensing and signalling
... (System ASC and y+ L) may also be dependent on transmembrane electrical gradients. System L operates as an obligatory 1:1 amino acid exchanger which can couple the cellular uptake of essential branched-chain and aromatic amino acids with the efflux (by hetero-exchange) of cytoplasmic amino acids suc ...
... (System ASC and y+ L) may also be dependent on transmembrane electrical gradients. System L operates as an obligatory 1:1 amino acid exchanger which can couple the cellular uptake of essential branched-chain and aromatic amino acids with the efflux (by hetero-exchange) of cytoplasmic amino acids suc ...
BAFF, APRIL and their receptors: Structure, function - Serval
... BAFF-R and BCMA (and TACI) lack a signal peptide and are therefore classified as Type III membrane proteins. Exon 1 encodes the ligand-binding domain (also called cysteine-rich domain or CRD), exon 2 the transmembrane domain and flanking regions, and exon 3 the intracellular domain (Fig. 1B). The in ...
... BAFF-R and BCMA (and TACI) lack a signal peptide and are therefore classified as Type III membrane proteins. Exon 1 encodes the ligand-binding domain (also called cysteine-rich domain or CRD), exon 2 the transmembrane domain and flanking regions, and exon 3 the intracellular domain (Fig. 1B). The in ...
Increased Secretion of Lipoproteins in Transgenic Mice Expressing
... binds more tightly and prevents dissociation,13 with the result that the LDLR cannot recycle and is degraded. Gain-offunction PCSK9 mutants bind with even higher affinity than WT PCSK9.13 We showed that the D374Y mutation in PCSK9 was associated with a particularly severe clinical phenotype.14 This ...
... binds more tightly and prevents dissociation,13 with the result that the LDLR cannot recycle and is degraded. Gain-offunction PCSK9 mutants bind with even higher affinity than WT PCSK9.13 We showed that the D374Y mutation in PCSK9 was associated with a particularly severe clinical phenotype.14 This ...
The Hype on the Endothelin Signaling System Muscarinic Receptor
... Alomone Labs Ltd. is a privately owned biotechnology company, founded in 1989. Our headquarters is based in Jerusalem, Israel. The company specializes in the development of a wide variety of innovative ion channel and GPCR molecular tools and other cell signaling related products. ...
... Alomone Labs Ltd. is a privately owned biotechnology company, founded in 1989. Our headquarters is based in Jerusalem, Israel. The company specializes in the development of a wide variety of innovative ion channel and GPCR molecular tools and other cell signaling related products. ...
Hepatic Secretion of Conjugated Drugs and Endogenous Substances
... on an amino acid alignment. Despite the fact that these three MRP isoforms share only a relatively low degree of amino acid identity, a close evolutionary relationship of these transporters is indicated by their similar genomic organization. The identification of MRP3, MRP4, MRP5, and MRP6 was mainl ...
... on an amino acid alignment. Despite the fact that these three MRP isoforms share only a relatively low degree of amino acid identity, a close evolutionary relationship of these transporters is indicated by their similar genomic organization. The identification of MRP3, MRP4, MRP5, and MRP6 was mainl ...
Lipolysis Exposes Unreactive Endogenous Apolipoprotein E-3
... receptor binding processes. Yet catabolism of VLDL-remnants by cellular receptors depends on functional apo E molecules. To better understand remnant catabolism phenomena, we determined the metabolism of VLDL and post-lipolysis VLDL by cultured cells. Partial lipolysis was achieved by incubation of ...
... receptor binding processes. Yet catabolism of VLDL-remnants by cellular receptors depends on functional apo E molecules. To better understand remnant catabolism phenomena, we determined the metabolism of VLDL and post-lipolysis VLDL by cultured cells. Partial lipolysis was achieved by incubation of ...
Subcellular Trafficking of Mammalian Lysosomal Proteins: An
... bind to monomeric clathrin adaptor proteins known as GGAs (Golgi-localizing, gamma-adaptin ear domain homology, ARF-binding proteins). At the PM, the adaptor protein complex AP-2 recognizes NPXY, YXXΦ and [D/E]XXXL[L/I] signals. In addition, NPXY signals can also bind to other cell surface clathrin- ...
... bind to monomeric clathrin adaptor proteins known as GGAs (Golgi-localizing, gamma-adaptin ear domain homology, ARF-binding proteins). At the PM, the adaptor protein complex AP-2 recognizes NPXY, YXXΦ and [D/E]XXXL[L/I] signals. In addition, NPXY signals can also bind to other cell surface clathrin- ...
Atlantic Salmon Interferon Genes: Cloning, Sequence Analysis
... ter of genes lacking introns, in contrast to type II IFN (IFN-g), which is encoded by a single intron-containing gene.(7) IFN-g is produced by T lymphocytes and natural killer (NK) cells in response to mitogens, antigens, or interleukin-12 (IL-12) and is nonhomologous to type I IFNs.(7) Type I IFNs ...
... ter of genes lacking introns, in contrast to type II IFN (IFN-g), which is encoded by a single intron-containing gene.(7) IFN-g is produced by T lymphocytes and natural killer (NK) cells in response to mitogens, antigens, or interleukin-12 (IL-12) and is nonhomologous to type I IFNs.(7) Type I IFNs ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.