Gain-of-Function Mutations in SCN5A Gene Lead to Type
... transgenic mice carrying R1193Q mutation. Besides, quinidine, an anti-arrhythmic medication, can cause arrhythmic symptoms such as premature ventricular contraction (PVC), premature atrial contraction (PAC) and atrioventricular (AV) block in R1193Q transgenic mice. In order to further study the rela ...
... transgenic mice carrying R1193Q mutation. Besides, quinidine, an anti-arrhythmic medication, can cause arrhythmic symptoms such as premature ventricular contraction (PVC), premature atrial contraction (PAC) and atrioventricular (AV) block in R1193Q transgenic mice. In order to further study the rela ...
Renal tubular Sirt1 attenuates diabetic albuminuria by
... The β-catenin/Snail pathway plays a role in the pathogenesis of albuminuria27, and Claudin-1 reportedly activates the β-catenin/Snail pathway in colon epithelial cells28. Thus, we examined whether Claudin-1 activated the β-catenin/Snail pathway in podocytes. Transfer of Claudin-1 gene upregulated bo ...
... The β-catenin/Snail pathway plays a role in the pathogenesis of albuminuria27, and Claudin-1 reportedly activates the β-catenin/Snail pathway in colon epithelial cells28. Thus, we examined whether Claudin-1 activated the β-catenin/Snail pathway in podocytes. Transfer of Claudin-1 gene upregulated bo ...
Ryanodine receptors: next generation of insecticide targets
... reticulum of muscle cells and neurons. They are the largest ion channels known made up of four monomers, each 565kDa in size. Mammals have 3 different RyR isoforms, encoded by different genes, while insects express only one isoform of the receptor, which is only 46% similar (at the amino acid level) ...
... reticulum of muscle cells and neurons. They are the largest ion channels known made up of four monomers, each 565kDa in size. Mammals have 3 different RyR isoforms, encoded by different genes, while insects express only one isoform of the receptor, which is only 46% similar (at the amino acid level) ...
Heterozygous LmnadelK32 mice develop dilated
... (http://www.umd.be/LMNA/), which lead to a wide spectrum of diseases collectively referred to as laminopathies (4). These pathologies involve either specific tissues (striated muscles, adipose tissue, peripheral nerves) or several systems (progeroid syndromes) with overlapping phenotypes. Among the ...
... (http://www.umd.be/LMNA/), which lead to a wide spectrum of diseases collectively referred to as laminopathies (4). These pathologies involve either specific tissues (striated muscles, adipose tissue, peripheral nerves) or several systems (progeroid syndromes) with overlapping phenotypes. Among the ...
Intragenic Revertants of Yeast Invertase Variants with Secretion-Defective Leader Sequences.
... the secretory pathway (C. A. Kaiser, Ph.D. thesis, Massachusetts Institute of Technology, Cambridge, 1987). Thus, these amino-terminal residues constitute a signal sequence for secretion. They are necessary for invertase secretion, since the constitutive form of invertase remains in the cytoplasm, a ...
... the secretory pathway (C. A. Kaiser, Ph.D. thesis, Massachusetts Institute of Technology, Cambridge, 1987). Thus, these amino-terminal residues constitute a signal sequence for secretion. They are necessary for invertase secretion, since the constitutive form of invertase remains in the cytoplasm, a ...
Bacterial Quorum-Sensing Network Architectures
... Gram-positive peptide autoinducers are not variations on a single core molecule. Rather, peptide autoinducers are genetically encoded, and thus each species of bacteria is capable of producing a peptide signal with a unique sequence (Figure 1b). Consistent with this, although Gram-positive quorum-se ...
... Gram-positive peptide autoinducers are not variations on a single core molecule. Rather, peptide autoinducers are genetically encoded, and thus each species of bacteria is capable of producing a peptide signal with a unique sequence (Figure 1b). Consistent with this, although Gram-positive quorum-se ...
Cell lysate and SR-enriched membrane fraction (SR - HAL
... mice expressing hMR in the heart (hMR mice, Fig.1A), we observed oscillations in membrane potential following completion of the driven AP (Fig.1A middle). Eventually, the DAD was large enough to reach the threshold to trigger spontaneous AP (Fig.1A right). The occurrence of DADs was greatly enhanced ...
... mice expressing hMR in the heart (hMR mice, Fig.1A), we observed oscillations in membrane potential following completion of the driven AP (Fig.1A middle). Eventually, the DAD was large enough to reach the threshold to trigger spontaneous AP (Fig.1A right). The occurrence of DADs was greatly enhanced ...
The serine protease Corin is a novel modifier of the agouti pathway
... The hair follicle is an important model system for the study of organogenesis: in part, because of the attributes that make it amenable to study during follicular neogenesis in the embryo and newborn animal; and, in part, because the lower portion of the hair follicle is regenerated from comparative ...
... The hair follicle is an important model system for the study of organogenesis: in part, because of the attributes that make it amenable to study during follicular neogenesis in the embryo and newborn animal; and, in part, because the lower portion of the hair follicle is regenerated from comparative ...
The Role of Carnitine System in Maintaining Muscle Homeostasis
... as a carrier of acyl moieties, and exclusively of longchain fatty acids for mitochondrial beta-oxidation in mammals [4, 20]. The trimethylated nitrogen group composing the molecule provides carnitine with osmolyte properties as seen for other components (the osmolytes glycine betaine, trimethylamine ...
... as a carrier of acyl moieties, and exclusively of longchain fatty acids for mitochondrial beta-oxidation in mammals [4, 20]. The trimethylated nitrogen group composing the molecule provides carnitine with osmolyte properties as seen for other components (the osmolytes glycine betaine, trimethylamine ...
R on Dendritic Cells - The Journal of Immunology
... trauma to reach acute phase levels as high as 100 –500 g/ml (7, 8). CRP interacts with the immune system by activating the classical complement pathway leading to opsonization (9, 10) and by direct binding to receptors on leukocytes leading to phagocytosis and cytokine synthesis. We established the ...
... trauma to reach acute phase levels as high as 100 –500 g/ml (7, 8). CRP interacts with the immune system by activating the classical complement pathway leading to opsonization (9, 10) and by direct binding to receptors on leukocytes leading to phagocytosis and cytokine synthesis. We established the ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.