Regulation of Nerve Growth Factor Receptor Gene Expression by
... Figure 1. Expression of the NGF receptor, tyrosine hydroxylase, and neuropeptide Y mRNAs in the postnatal day 12 SCG with and without NGF treatment. Northern blot analysis of (a) NGF receptor, (b) tyrosine hydroxylase, and (c) neuropeptide Y mRNAs in equal amounts of total RNA from the SCG of an an ...
... Figure 1. Expression of the NGF receptor, tyrosine hydroxylase, and neuropeptide Y mRNAs in the postnatal day 12 SCG with and without NGF treatment. Northern blot analysis of (a) NGF receptor, (b) tyrosine hydroxylase, and (c) neuropeptide Y mRNAs in equal amounts of total RNA from the SCG of an an ...
Targeted Disruption of the SUCNR1 Metabolic Receptor
... receptors are tasked with the recognition and transmission of messages from the external environment. An everincreasing number of GPCRs are now being identified as receptors for metabolites or energy substrates (2), expanding the repertoire of biological targets to diseases associated with the metabo ...
... receptors are tasked with the recognition and transmission of messages from the external environment. An everincreasing number of GPCRs are now being identified as receptors for metabolites or energy substrates (2), expanding the repertoire of biological targets to diseases associated with the metabo ...
Structure and Expression of Genes for a Class of Cysteine
... vitro expression data identify them as ultra-high-sulfur (UHS) keratin proteins. The predicted proteins are composed almost entirely of cysteine-rich and glycinerich repeats. Genomic blots reveal that the UHS keratin proteins are encoded by related multigene families in both the human and sheep geno ...
... vitro expression data identify them as ultra-high-sulfur (UHS) keratin proteins. The predicted proteins are composed almost entirely of cysteine-rich and glycinerich repeats. Genomic blots reveal that the UHS keratin proteins are encoded by related multigene families in both the human and sheep geno ...
Mutational Analysis of Synaptobrevin Transmembrane Domain
... The vast majority of information about SNAREs arises from studies of the soluble cytoplasmic domains, but it is now becoming clear that the transmembrane domains affect both the structure and the function of SNAREs. Synaptobrevin forms a complex with synaptophysin that is dependent on the presence o ...
... The vast majority of information about SNAREs arises from studies of the soluble cytoplasmic domains, but it is now becoming clear that the transmembrane domains affect both the structure and the function of SNAREs. Synaptobrevin forms a complex with synaptophysin that is dependent on the presence o ...
Fig. 2a
... necrosis factor (TNF), IL-6, IL-12 and IL-23) and tumor suppressors11. Consequently, Irf5-deficient mice are resistant to lethal endotoxic shock12. Human IRF5 is expressed in many splice variants with distinct cell type–specific expression, cellular localization, differences in regulation and funct ...
... necrosis factor (TNF), IL-6, IL-12 and IL-23) and tumor suppressors11. Consequently, Irf5-deficient mice are resistant to lethal endotoxic shock12. Human IRF5 is expressed in many splice variants with distinct cell type–specific expression, cellular localization, differences in regulation and funct ...
INTERNATIONAL WORKSHOP
... both wild type and mdx mice (a model of Duchenne muscular dystrophy), resulted in an increase in skeletal muscle mass and strength. We are currently evaluating a human anti-myostatin monoclonal antibody, MYO-029, in clinical trials in both healthy volunteers and patients with muscular dystrophy. Add ...
... both wild type and mdx mice (a model of Duchenne muscular dystrophy), resulted in an increase in skeletal muscle mass and strength. We are currently evaluating a human anti-myostatin monoclonal antibody, MYO-029, in clinical trials in both healthy volunteers and patients with muscular dystrophy. Add ...
Document
... of hibernating grizzly bears using high-throughput proteomics and RNA-Seq. The changes in protein expression indicate an effect on muscle metabolism, consistent with increased nonessential amino acid levels and a decrease in ATP production. Supplementing murine myotubes with non-essential amino acid ...
... of hibernating grizzly bears using high-throughput proteomics and RNA-Seq. The changes in protein expression indicate an effect on muscle metabolism, consistent with increased nonessential amino acid levels and a decrease in ATP production. Supplementing murine myotubes with non-essential amino acid ...
Supplementary Data - Institute of Cancer Research
... PGRP-LC isoforms LCa, LCx and LCy 13, 29, 30. This cytosolic tail lacks any obvious endocytic motifs, and no ligand-induced trafficking of the receptor has been reported so far. A closer look at the PGRP-LC locus revealed a potential alternative first coding exon, which might encode a functionally d ...
... PGRP-LC isoforms LCa, LCx and LCy 13, 29, 30. This cytosolic tail lacks any obvious endocytic motifs, and no ligand-induced trafficking of the receptor has been reported so far. A closer look at the PGRP-LC locus revealed a potential alternative first coding exon, which might encode a functionally d ...
Nicotinamidase modulation of NAD biosynthesis and nicotinamide
... Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans Tracy L. Vrablik*, Li Huang*,†, Stephanie E. Lange and Wendy Hanna-Rose‡ Nicotinamide adenine dinucleotide (NAD+) is a central molecule in cellular metabo ...
... Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans Tracy L. Vrablik*, Li Huang*,†, Stephanie E. Lange and Wendy Hanna-Rose‡ Nicotinamide adenine dinucleotide (NAD+) is a central molecule in cellular metabo ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.