Lipid-like materials for low-dose, in vivo gene silencing Please share
... cholesterol and polyethylene glycol (PEG) were used in the formulations (15). For in vivo screening experiments, lipidoids were formulated at a constant weight ratio of lipidoid∶DSPC∶ cholesterol∶PEG and mice were administered a single bolus dose of 3 mg∕kg total siRNA via tail vein injection. Mouse ...
... cholesterol and polyethylene glycol (PEG) were used in the formulations (15). For in vivo screening experiments, lipidoids were formulated at a constant weight ratio of lipidoid∶DSPC∶ cholesterol∶PEG and mice were administered a single bolus dose of 3 mg∕kg total siRNA via tail vein injection. Mouse ...
Decrease in Reactive Amino Groups during Oxidation or Endothelial
... resulted in a modification that was indistinguishable from that produced by endothelial cells. Moreover, it was demonstrated that LDL oxidation by either method is accompanied by a marked decrease in amino group reactivity, comparable to that seen with the chemical modifications of LDL that lead to ...
... resulted in a modification that was indistinguishable from that produced by endothelial cells. Moreover, it was demonstrated that LDL oxidation by either method is accompanied by a marked decrease in amino group reactivity, comparable to that seen with the chemical modifications of LDL that lead to ...
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... specific SS. This plays an important role as the consensus sequences that make up the 51 SS, 31 SS and BPS are degenerate in higher eukaryotes where alternative splicing is predominant [5]. This also results in SS alone not being capable of efficiently directing spliceosomal assembly. SR and hnRNP p ...
... specific SS. This plays an important role as the consensus sequences that make up the 51 SS, 31 SS and BPS are degenerate in higher eukaryotes where alternative splicing is predominant [5]. This also results in SS alone not being capable of efficiently directing spliceosomal assembly. SR and hnRNP p ...
GATA-2 functions downstream of BMPs and CaM KIV in ectodermal
... activity. In contrast, the N-terminus of 1-Smads has a weak sequence homology to the MH1 domain of R-Smads and does not bind to DNA (Shi and Massague, 2003). Smads bind to a consensus motif called the Smad-binding element (SBE) on target DNA, which has the sequence GCTC. Smad targets contain one or ...
... activity. In contrast, the N-terminus of 1-Smads has a weak sequence homology to the MH1 domain of R-Smads and does not bind to DNA (Shi and Massague, 2003). Smads bind to a consensus motif called the Smad-binding element (SBE) on target DNA, which has the sequence GCTC. Smad targets contain one or ...
Steroid Hormone Induction Of Temporal Gene Expression
... down-regulating the early factor Chinmo and expressing the late factor Broad by the end of the culture period ...
... down-regulating the early factor Chinmo and expressing the late factor Broad by the end of the culture period ...
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... As recently as the early to mid-1980s, before the advent of many useful molecular methods that we now take for granted, only genes for rhodopsin and the human cone pigments had been cloned and there was no reliable method for heterologous expression of receptors. By that time, Khorana had already co ...
... As recently as the early to mid-1980s, before the advent of many useful molecular methods that we now take for granted, only genes for rhodopsin and the human cone pigments had been cloned and there was no reliable method for heterologous expression of receptors. By that time, Khorana had already co ...
Cellular Pathology
... (a) Storage diseases Definition: Excess accumulation of complex substrates within lyzosomes as a result of a genetic enzymatic defect in a specific metabolic ...
... (a) Storage diseases Definition: Excess accumulation of complex substrates within lyzosomes as a result of a genetic enzymatic defect in a specific metabolic ...
Enhancer timing of Hox gene expression: deletion of
... Simon and Tamkun, 2002). In the Pc-G family M33 null ...
... Simon and Tamkun, 2002). In the Pc-G family M33 null ...
Recent advances in renal tubular calcium reabsorption
... disease [50,51,52]. The Klotho gene encodes a single- ...
... disease [50,51,52]. The Klotho gene encodes a single- ...
Fcg Receptor Deficiency Attenuates Diabetic Nephropathy
... adaptive immunity. Most forms of modified LDL are immunogenic and induce autoantibody production; these proinflammatory properties are greatly increased by the formation of LDL-containing immune complexes.8 This adaptive immune response to modified LDL has also been reported in mice.9 Patients with typ ...
... adaptive immunity. Most forms of modified LDL are immunogenic and induce autoantibody production; these proinflammatory properties are greatly increased by the formation of LDL-containing immune complexes.8 This adaptive immune response to modified LDL has also been reported in mice.9 Patients with typ ...
Molecular Characterization of Calymmin, a Novel Notochord Sheath
... Based on these observations, clone c39a was assumed to encode a full-length polypeptide of 1,207 amino acids, with a molecular mass of 122 kDa and a pI of 10.50. A noteworthy feature of the primary sequence is its elevated content in glycine residues (20.2%). The first 20 amino acids in the sequence ...
... Based on these observations, clone c39a was assumed to encode a full-length polypeptide of 1,207 amino acids, with a molecular mass of 122 kDa and a pI of 10.50. A noteworthy feature of the primary sequence is its elevated content in glycine residues (20.2%). The first 20 amino acids in the sequence ...
G protein
... Many Seven-Membrane Spanning Receptors Act via G Proteins • A portion of an activated G protein binds a target protein, altering its activity • A class of receptors of great clinical importance is the opioid receptors, to which narcotic drugs such as morphine bind ...
... Many Seven-Membrane Spanning Receptors Act via G Proteins • A portion of an activated G protein binds a target protein, altering its activity • A class of receptors of great clinical importance is the opioid receptors, to which narcotic drugs such as morphine bind ...
Fcg Receptor Deficiency Attenuates Diabetic Nephropathy
... adaptive immunity. Most forms of modified LDL are immunogenic and induce autoantibody production; these proinflammatory properties are greatly increased by the formation of LDL-containing immune complexes.8 This adaptive immune response to modified LDL has also been reported in mice.9 Patients with typ ...
... adaptive immunity. Most forms of modified LDL are immunogenic and induce autoantibody production; these proinflammatory properties are greatly increased by the formation of LDL-containing immune complexes.8 This adaptive immune response to modified LDL has also been reported in mice.9 Patients with typ ...
VLDL receptor
The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.