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What is life when it is not protected from virus-driven entropy?
J.V. Kohl
RNA-mediated.com, Epworth, GA
Energy-dependent nutritional epigenetics
Everything currently known to physicists, chemists, and molecular
biologists attests to the following representations.
The speed of light on contact with water [1] links the energy-dependent de
novo creation of nucleic acids and photosynthesis from metabolic networks
to genetic networks. [2]
Conserved molecular mechanisms link hydrogen-atom transfer in DNA
base pairs in solution from microRNA flanking sequences to base pair
substitutions. [3]
The base pair substitutions link RNA-mediated amino acid substitutions to
adhesion proteins. For example, the ribosome links heat shock proteins to
biophysically constrained nutrient energy-dependent RNA-mediated protein
folding chemistry and cell type differentiation via supercoiled DNA in the
context of the physiology of reproduction. [4]
Distinct nutrient energy-dependent pathways link microRNA biogenesis
from RNAs to biological functions, but the distinct pathways are typically
examined collectively. [5] The collective examination of nutrient-dependent
RNA-mediated de novo gene creation and chemotaxis is not always
phylogenetically linked to coordinated phototaxis and responses to other
sensory input throughout life history transitions in all living genera.
Virus-perturbed neural
circuitry, odor hedonics, mood,
memory, motivation,
expressions of affect, cognitive
behavioral state, and
potentiating responses to other
stimuli links mutations to all
pathology
For example, metabolic energy links guanine nucleotide binding proteins (G
proteins) to the experience-dependent de novo creation of monoallelic G
protein-coupled receptors (GPCRs). Ligand-receptor binding links the de
novo creation of olfactory receptor genes, which are GPCRs, to the creation
of other receptors such as photoreceptors. [7-9]
[1] Single-residue insertion switches the quaternary structure and exciton states of
cryptophyte light-harvesting proteins
[2] Common origins of RNA, protein and lipid precursors in a cyanosulfidic
protometabolism
[3] The phylogenetic utility and functional constraint of microRNA flanking sequences
[4] Structural diversity of supercoiled DNA
[5] Single-molecule fluorescence measurements reveal the reaction mechanisms of
the core-RISC, composed of human Argonaute 2 and a guide RNA
[6] Regulatory evolution of innate immunity through co-option of endogenous
retroviruses
[7] UV-Induced Charge Transfer States in DNA Promote Sequence Selective SelfRepair
[8] An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
[9] Experience Affects Critical Period Plasticity in the Visual Cortex through an
Epigenetic Regulation of Histone Post-Translational Modifications
See also
Neuroscience of Early-Life Learning in C. elegans
Differential Odour Coding of Isotopomers in the Honeybee Brain
Breast Milk Sugars Support Infant Gut Health
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair,
FOXO, and sirtuins
Ancient virus found hibernating in the human genome—and it might wake up
Water
Aging
microRNA (miRNA) biogenesis,
Chemistry
alternative splicings / pre-mRNA
Molecular Epigenetics
Life history transistions
Learning and Memory
RNA-mediated events
Nutritional epigenetics
Negative
DNA base pair
substitutions
miRNA/mRNA
balance
Brain development
Positive
Feedback
olfactory receptor genes,
Photosynthesis
microRNA flanking
sequence
Sexuallity
de novo creation of nucleic acids,
Quantum Physics
Hydrogen atom transfer in
DNA base pairs in solution
Pathology
Chemosensory input is the first phylogenetically conserved link from the
epigenetic landscape to the physical landscape of supercoiled DNA, which
appears to protect all organized genomes from virus-driven entropy in the
context of the nutrient-dependent innate immune system. [6]
Sunlight
Food odors
Pheromones
Feedback loops
Physiology
Supercoiled DNA
DNA repair
Tonic
Neurotransmission
Synaptogenesis
Synaptolysis
Apoptosis
Synaptogenesis
Synaptolysis
Apoptosis
Excessive STRESS
and changes in pH
Virus-driven
energy theft
Unfortunately, claims about new ways to build molecules are not tethered to what is
known about the need for an anti-entropic force that prevents dissipation of energy via
amino acid substitutions that stabilize the organized genomes of all living genera. [1415]. For example, achiral glycine in position 6 of the GnRH decapeptide is linked to the
stability of all organized genome in all vertebrates.[16]
Prevention of increased virulence appears to be nutrient-dependent and controlled by
the physiology of reproduction. Transgenerational epigenetic effects of food odors and
pheromones link supercoiled DNA to protection from virus-driven entropy.
For example, the quality of foraging in crustaceans and insects links microRNA
flanking sequences from sunlight to energy metabolism and genetic networks via
amino acids and transgenerational epigenetic inheritance of sex differences in
morphological and behavioral phenotypes in bulls, cows and humans. [17-18]
Conserved molecular mechanisms link nutrient energy-dependent changes in
microRNAs to cell type differentiation and morphological and behavioral phenotypes of
humans. [19]
Longevity
Cyclic
The energy that is stolen is required to link nutrient-dependent RNA-mediated amino
acid substitutions to the de novo creation of receptors that allow more nutrients or
different nutrients to enter different cell types. The accumulation of viruses prevents
nutrient-dependent cell type differentiation. The viruses link perturbed protein folding
from mutations to pathology via metabolic networks and genetic networks in the
context of the Precision Medicine Initiative. [12-13]
Reproduction
RNA-mediated
amino acid substitutions
Cell type differentiation via
protein folding chemistry
Virus-driven energy theft and pathology.
Retroviral integrase catalyses the integration of viral DNA into host target DNA.[10]
Viruses enter cells and they steal metabolic energy to replicate.[11]
Thermodynamic
cycles of protein
biosynthesis and
degradation
Every aspect of cell type differentiation has been linked to energy-dependent changes
in hydrogen-atom transfer in DNA base pairs in solution from bacteria [20] to
nematodes [21] and all mammals.[22] via RNA mediated events, which are perturbed
by viruses, which have been linked from energy theft to all pathology by as little as a
single base pair change and single amino acid substitution during life history
transitions.[23-24]
[10] Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome
function
[11] Substitutions Near the Receptor Binding Site Determine Major Antigenic Change
During Influenza Virus Evolution
Mutations
Gonads
HPA
[12] RNA-Mediated Regulation of HMGA1 Function
axis
[13] An expanded sequence context model broadly explains variability in polymorphism
Epigenetic
Epigenetic
levels across the human genome
Inheritance
Inheritance
[14] Ligand-Controlled C(sp3)–H Arylation and Olefination in Synthesis of Unnatural
Chiral α–Amino Acids
Minimal stress
HPG
[15] Dissipation Bounds All Steady-State Current Fluctuations
axis
[16] Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation
and Receptor Selectivity
[17] The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm
MicroRNA Expression
"...in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the
[18] Systematic microRNAome profiling reveals the roles of microRNAs in milk protein
extremely well-ordered state of matter in more or less complicated organic compounds, which serve them asmetabolism and quality: insights on low-quality forage utilization
foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for [19] Human milk miRNAs primarily originate from the mammary gland resulting in
plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the unique miRNA profiles of fractionated milk
sunlight)" -- Schrodinger (1944)
20] Design and synthesis of a minimal bacterial genome
[21] A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to
Ensure Embryonic Divisions
[22] Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos
HPA: hypothalamic-pituitary-adrenal axis; HPG: hypothalamic-pituitary-gonadal axis
[23] Stress dynamically regulates behavior and glutamatergic gene expression in
hippocampus by opening a window of epigenetic plasticity
[24] Oppositional COMT Val158Met effects on resting state functional connectivity in
Molecular Diagnostics (Labroots) April 6-7, 2016
adolescents and adults
Entropy
Contact: [email protected]