Download The biosynthetic basis of budding yeast cell size control

Invitation to Seminar Talk
The biosynthetic basis of budding
yeast cell size control
Kurt Schmoller
Department of Biology, Stanford University
Cell size is an important physiological trait that sets the scale of all biosynthetic
processes. Although physiological studies have revealed that cells actively
regulate their size, the molecular mechanisms underlying this regulation have
remained unclear. Using quantitative single cell microscopy, we identified the
molecular mechanism coupling growth and division in budding yeast. As cells
grow, they dilute a cell cycle inhibitor while keeping the upstream activator at
a constant concentration, which results in a continuously increasing probability
for cell cycle entry. Size control itself is ensured by a differential dependence
of activator and inhibitor synthesis rates on cell size. We anticipate that
differential size dependence of biosynthesis is a widespread mechanism that
allows cells to link their protein content to cell size and encode size
dependence into the activity of any regulatory network.
Thursday, March 10, 2016, 8:45 am
Seminar room, Lab Building West, ground floor
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