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Invitation to Seminar Talk Imaging and Repairing Synapses with Chemical Tools Dalibor Sames Columbia University Host: Harald Janovjak In this lecture I will discuss our progress on the pursuit of two interconnected longterm goals: visualization and repair of synaptic function with chemical tools. First, I will describe how this overarching theme led us to the development of conceptually new imaging agents, termed fluorescent false neurotransmitters (or FFNs). FFN probes as fluorescent tracers of endogenous neurotransmitters enable microscopic imaging of neurotransmitter release from individual presynaptic sites and form the basis of experimental platforms that afford new insights into functional properties of synapses and effects of drugs. Generality of the FFN concept including the strengths and limitations will be discussed. As the second topic, I will describe how three structurally distinct compounds (one synthetic pharmaceutical and two natural products) with remarkable clinical and preclinical activities led us to the opioid receptors and their signaling. An update on synthetic, pharmacological and behavioral projects will be provided. Throughout the lecture I will touch on the gaps in the current understanding of relationships between the different levels of complexity (from molecules to cellular responses, circuits to behavior) in the context of drug and chemical probe development. Tuesday, June 21, 2016, 10:30am Seminar room, Lab Building East, ground floor This invitation is valid as a ticket for the IST Shuttle from and to Heiligenstadt Station. Please find a schedule of the IST Shuttle on our webpage (note that the IST Shuttle times are highlighted in dark green): http://ist.ac.at/fileadmin/user_upload/pdfs/IST_shuttle_bus.pdf The IST Shuttle bus is marked IST Shuttle (#242) and has the Institute Logo printed on the side. Institute of Science and Technology Austria | Am Campus 1 | 3400 Klosterneuburg www.ist.ac.at