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Download Table S13. Description of TCOF1 related proteins
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Table S13. Description of TCOF1 related proteins analysed by STRING database Gene Name Reference Number Description 9606.ENSP0000 HBG2 hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains 0338082 POLR1 9606.ENSP0000 polymerase (RNA) I polypeptide C, 30kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common C 0361465 component of RNA polymerases I and III which synthesize ribosomal RNA precu 9606.ENSP0000 chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex 0301019 necessary to initiate DNA replication. Binds DNA in a sequence-, CDT1 9606.ENSP0000 NOP56 microRNA 1292; Required for 60S ribosomal subunit biogenesis 0370589 9606.ENSP0000 ANXA6 annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores 0346550 9606.ENSP0000 replication factor C (activator 1) 1, 145kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This 0261424 subunit binds to the primer-template junction. Binds the PO-B 9606.ENSP0000 flap structure-specific endonuclease 1; Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a 0305480 downstream Okazaki fragment. Also possesses 5' to 3' exonuclease CDKN1 9606.ENSP0000 cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and A 0244741 inhibits cyclin-dependent kinase activity, preventing phos 9606.ENSP0000 replication factor C (activator 1) 3, 38kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear 0369411 antigen (PCNA) and activator 1 9606.ENSP0000 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the 0261797 glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharid 9606.ENSP0000 replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear 0296273 antigen (PCNA) and activator 1. This subunit may be involved i RFC1 FEN1 RFC3 NDST1 RFC4 9606.ENSP0000 CDK4 cyclin-dependent kinase 4; Probably involved in the control of the cell cycle 0257904 9606.ENSP0000 MKLN1 muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin 1 (By similarity) 0323527 9606.ENSP0000 upstream binding transcription factor, RNA polymerase I; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions 0302640 with the transcription factor SL1/TIF-IB complex. It binds specif 9606.ENSP0000 replication factor C (activator 1) 2, 40kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear 0055077 antigen (PCNA) and activator 1. This subunit binds ATP (By sim UBTF RFC2 9606.ENSP0000 CCND1 cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition 0227507 GADD4 9606.ENSP0000 5G 0252506 growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK 9606.ENSP0000 mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby 0234420 initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields 9606.ENSP0000 proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's 0368438 processibility during elongation of the leading strand (By similar MSH6 PCNA 9606.ENSP0000 LIG1 ligase I, DNA, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair 0263274 9606.ENSP0000 transducin (beta)-like 1X-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in 0217964 transcription activation mediated by nuclear receptors. 9606.ENSP0000 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 0233146 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA 9606.ENSP0000 polymerase (DNA directed), delta 1, catalytic subunit 125kDa; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in 0262266 the 3'- to 5'-direction. Required with its accessory proteins GADD4 9606.ENSP0000 growth arrest and DNA-damage-inducible, alpha; Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA 5A 0360025 excision repair in vitro and inhibits entry of cells into S ph 9606.ENSP0000 DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation 0352516 pattern in the newly synthesized strand, that is essential for epige TBL1X MSH2 POLD1 DNMT1 9606.ENSP0000 Treacher Collins-Franceschetti syndrome 1; May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the 0406888 craniofacial complex (By similarity) TCOF1 9606.ENSP0000 POLD3 polymerase (DNA-directed), delta 3, accessory subunit; Required for optimal DNA polymerase delta activity 0263681 DYNC1 9606.ENSP0000 dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the H1 0348965 force-producing power stroke is thought to occur on release o 9606.ENSP0000 POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa; The function of the small subunit is not yet clear 0379148 POLR1 9606.ENSP0000 polymerase (RNA) I polypeptide D, 16kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core D 0302478 component of RNA polymerases I and III which synthesize ribosomal RNA 9606.ENSP0000 replication factor C (activator 1) 5, 36.5kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear 0408295 antigen (PCNA) and activator 1 RFC5